l i t e r a t u r e of organic s y n t h e s e s i n general a n d t h e second a guide t o t h e l i t e r a t u r e on organic s y n t h e s e s w i t h p o s i t r o n e m i t t e r s i n p a r t i c u l a r .After a general i n t r o d u c t i o n r e l a t i n g t h e p h y s i c a l p r o p e r t i e s of t h e t h r e e p o s i t r o n emitters a n d t h e i r importance i n p o s i t r o n emission t r a n s a x i a l
tomography ( P E T T ) , t h e general c o n s i d e r a t i o n s i n t h e design of r a d i d t r a c e r s a r e d i s c u s s e d .T h i s i n c l u d e s t h e choice a n d position of t h e l a b e l p e r t a i n i n g t o t h e use of t h e r a d i o t r a c e r , which of c o u r s e a r e fundamental c o n s i d e r a t i o n s for a n y s t u d i e s with t r a c e r compounds.
The arrangement of t h e t e x t in t h e next s e c t i o n on Radiotracer S y n t h e s i s may have been improved b y not confronting t h e r e a d e r s o e a r l y w i t h t a b l e s of l a b a l l e d compounds. T h i s s e c t i o n c o n s i d e r s t h e s y n t h e t i c s t r a t e g i e s t o be a d o p t e d , t h e a v a i l a b i l i t y of a p p r o p r i a t e p r e c u r s o r s , optimisation of r e a c t i o n r a t e s , s p e c i f i c a c t i v i t y a n d stoichiometry . When e x p r e s s i n g y i e l d s a n d s p e c i f i c a c t i v i t i e s t h e Authors r i g h t l y draw a t t e n t i o n to t h e use of EOB ( e n dof c y c l o t r o n or a c c e l e r a t o r bombardment) a n d EOS ( e n d of s y n t h e s i s ) a s r e f e r e n c e p o i n t s , t h u s e l i m i n a t i n g a m b i g u i t i e s r e l a t i n g to s y n t h e s i s time f o r example.