Biosynthesis of Novel Silver Nanoparticles Using Eryngium thyrsoideum Boiss Extract and Comparison of their Antidiabetic Activity with Chemical Synthesized Silver Nanoparticles in Diabetic Rats

Mahmoudi, Fariba; Mahmoudi, Farzaneh; Gollo, Khadijeh Haghighat; Amini, Mostafa M.

doi:10.1007/s12011-020-02315-4

Cited by 21 publications

(12 citation statements)

References 33 publications

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“…These properties enable them to integrate into various biotechnological and biomedical applications. The nanomaterial compounds have been fabricated using different routes including chemical, physical, and biological methods [ 3 ]. The physical methods were achieved under harsh working conditions and consumed high energy with complicated experimental devices [ 4 ], while the synthesis by chemical routes took place using deleterious organic solvents with dangerous reducing agents and produced undesirable by-products with negative impacts to the surrounding environment [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Rhizopus oryzae-Mediated Green Synthesis of Magnesium Oxide Nanoparticles (MgO-NPs): A Promising Tool for Antimicrobial, Mosquitocidal Action, and Tanning Effluent Treatment

Hassan

Fouda

Saied

et al. 2021

JoF

113

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The metabolites of the fungal strain Rhizopus oryaze were used as a biocatalyst for the green-synthesis of magnesium oxide nanoparticles (MgO-NPs). The production methodology was optimized to attain the maximum productivity as follows: 4 mM of precursor, at pH 8, incubation temperature of 35 °C, and reaction time of 36 h between metabolites and precursor. The as-formed MgO-NPs were characterized by UV-Vis spectroscopy, TEM, SEM-EDX, XRD, DLS, FT-IR, and XPS analyses. These analytical techniques proved to gain crystalline, homogenous, and well-dispersed spherical MgO-NPs with an average size of 20.38 ± 9.9 nm. The potentiality of MgO-NPs was dose- and time-dependent. The biogenic MgO-NPs was found to be a promising antimicrobial agent against the pathogens including Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, Escherichia coli, and Candida albicans with inhibition zones of 10.6 ± 0.4, 11.5 ± 0.5, 13.7 ± 0.5, 14.3 ± 0.7, and 14.7 ± 0.6 mm, respectively, at 200 μg mL–1. Moreover, MgO-NPs manifested larvicidal and adult repellence activity against Culex pipiens at very low concentrations. The highest decolorization percentages of tanning effluents were 95.6 ± 1.6% at 100 µg/ 100 mL after 180 min. At this condition, the physicochemical parameters of tannery effluents, including TSS, TDS, BOD, COD, and conductivity were reduced with percentages of 97.9%, 98.2%, 87.8%, 95.9%, and 97.3%, respectively. Moreover, the chromium ion was adsorbed with percentages of 98.2% at optimum experimental conditions.

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Section: Introductionmentioning

confidence: 99%

Rhizopus oryzae-Mediated Green Synthesis of Magnesium Oxide Nanoparticles (MgO-NPs): A Promising Tool for Antimicrobial, Mosquitocidal Action, and Tanning Effluent Treatment

Hassan

Fouda

Saied

et al. 2021

JoF

113

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“…In both cases, the peak corresponding to the (111) plane are more intense than the peaks of other planes. Interestingly, most of researchers [16], [22], [23], that synthesized the nanoparticles using plant extracts seem to obtained a similar crystal structure.…”

Section: Discussionmentioning

confidence: 99%

“…G3: Diabetic rats treated subcutaneous daily dose of mixed insulin 2 units/kg b.w [15] G4: Diabetic rats treated orally daily dose with dandelion leaf extract of 30mg/kg of b.w [12] G5: Diabetic rats intraperitonially daily dose with AgNPs 2.5mg/kg of b.w. [16] The period of experiment was 4 weeks. At the end of the experiment, the rats were fasted overnight, than euthanized under general anesthesia and sacrified.…”

Section: Experimental Designmentioning

confidence: 99%

Molecular study on the effect of dandelion leaf extract and silver nanoparticles in induced diabetic albino rats

Muhsin

Faris

Abdulridha

2022

ijhs

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The present study investigated the antidiabetic effects of dandelion leaf extract and silver nanoparticles on diabetic albino rats at molecular level, and compared with insulin. Silver nanoparticles were prepared by green chimestry method using dandelion leaf extract as capping and reducing agent, which reduced Silver nitrate (AgNO3) into silver nanoparticles. The morphology, size and crystalline structure, of silver nanoparticles are confirmed by ultraviolet, Scanning electron microscope technique, and X-ray diffraction respectively. The formation and stability of the reduced AgNPs in colloidal solution were detected and monitored by using UV-visible spectroscopy, and the absorption peak appear at 450 nm indicating the specific surface Plasmon resonance of AgNPs. The Scanning Electron Microscope showed that the AgNPs have spherical shape with aparticular size ranging from (13 to 28 )nm.The chemical characterization of synthesized AgNPs was tested using the X-ray diffraction technique, which shows that the average crystalline size was 16nm, and the synthesized silver nanoparticles have a polycrystalline structure. Application of nanoparticles in medicine is an attractive proposition. The present study included 35 female wistar albino rats weighting 200±20 grams.

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“…Antioxidants might be responsible for antidiabetic activity. The aqueous extract already proven for the presence of many polyphenols may be responsible for the antioxidant activity mediated antidiabetic activity [19,20]. Many plant-based silver nanoparticles compounds have been proven scienti cally for antidiabetic activity.…”

Section: Discussionmentioning

confidence: 99%

Development of Plant-Mediated Silver Nanoparticles & Their Pharmacological Evaluation

Shanker

Geetha

Banu

et al. 2022

Preprint

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Diabetes is among the most common debilitating and non-transferable diseases on the planet. The idea of using nanoparticles as a drug to treat diabetes mellitus seems intriguing. The Ag nanoparticles (Ag NPs) were effectively produced utilizing Moringa olifera (family: Moringaceae) plant extract employing a simple, cheaper, faster, and environmentally friendly green synthesis process. The antidiabetic effect of the produced Ag NPs was also tested in vivo. In the presence of plant extract, silver nitrate was converted to silver ions (Ag). XRD, FTIR, UV, XPS, and HRTEM studies characterize the formed Ag NPs. Ag NPs that have been biosynthesized, crystal nature was confirmed through XRD analysis and confirmed by UV-visible spectroscopy. FT-IR spectra were used to verify the presence of various functional groups in the biomolecules, forming and stabilizing the nanoparticles. The size of the NPS was in the range of 20-40 nm determined by HRTEM. The induction of diabetes using STZ showed increased blood glucose, cholesterol, triglycerides, LDL, VLDL, massive loss in body weight. These changes were reversed following the treatment of diabetic rats for 28 days and showed significant inhibition (p < 0.001) at a dose range of 0.2 mg/kg leaf extract and 0.2 mg/kg Ag NPs compared with the extract-treated group. These obtained results suggested that plant-mediated Ag NPs have shown promising antidiabetic and anti-hyperlipidemic activity compared to the crude extract.

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Biosynthesis of Novel Silver Nanoparticles Using Eryngium thyrsoideum Boiss Extract and Comparison of their Antidiabetic Activity with Chemical Synthesized Silver Nanoparticles in Diabetic Rats

Cited by 21 publications

References 33 publications

Rhizopus oryzae-Mediated Green Synthesis of Magnesium Oxide Nanoparticles (MgO-NPs): A Promising Tool for Antimicrobial, Mosquitocidal Action, and Tanning Effluent Treatment

Rhizopus oryzae-Mediated Green Synthesis of Magnesium Oxide Nanoparticles (MgO-NPs): A Promising Tool for Antimicrobial, Mosquitocidal Action, and Tanning Effluent Treatment

Molecular study on the effect of dandelion leaf extract and silver nanoparticles in induced diabetic albino rats

Development of Plant-Mediated Silver Nanoparticles & Their Pharmacological Evaluation

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Biosynthesis of Novel Silver Nanoparticles Using Eryngium thyrsoideum Boiss Extract and Comparison of their Antidiabetic Activity with Chemical Synthesized Silver Nanoparticles in Diabetic Rats

Cited by 21 publications

References 33 publications

Rhizopus oryzae-Mediated Green Synthesis of Magnesium Oxide Nanoparticles (MgO-NPs): A Promising Tool for Antimicrobial, Mosquitocidal Action, and Tanning Effluent Treatment

Rhizopus oryzae-Mediated Green Synthesis of Magnesium Oxide Nanoparticles (MgO-NPs): A Promising Tool for Antimicrobial, Mosquitocidal Action, and Tanning Effluent Treatment

Molecular study on the effect of dandelion leaf extract and silver nanoparticles in induced diabetic albino rats

Development of Plant-Mediated Silver Nanoparticles &amp; Their Pharmacological Evaluation

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Development of Plant-Mediated Silver Nanoparticles & Their Pharmacological Evaluation