Biosensors: fundamentals and applications

Turner, Anthony; Karube, Isao; Wilson, George S.; Worsfold, Paul J.

doi:10.1016/s0003-2670(00)85361-1

Cited by 629 publications

(405 citation statements)

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“…with a physicochemical detector [12]. A biosensor tool converts the signal of the interaction between the analyte and the biological element into an easily detectable signal such as light, voltage, current, mass, etc.…”

Section: Biosensorsmentioning

confidence: 99%

Synthesising Metal Oxide Materials and Their Composite Nanostructures for Sensing and Optoelectronic Device Applications

Khun¹

2015

Linköping Studies in Science and Technology. Dissertations

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Research on nanomaterials has been revolutionized in the last few years because of the attractive properties they have in comparison to the bulk phase of similar materials. These properties are physical, chemical, catalytic and optical. Among these nanomaterials, the metal oxide nanostructures have become of particular interest to scientists for the development of different optical, biochemical and biomedical nanodevices. In the present research work using the advantageous features of nanotechnology, high performance nanodevices for optoelectronics with a wide band gap compound nanostructure and highly sensitive sensor devices have been demonstrated. The nanotechnology is used to fabricate sensitive and precise nanodevices based on nanomaterials for the application of sensing.Among metal oxide nanostructures, ZnO, CuO and NiO are attractive materials because of their unique properties; their high surface area to volume ratio, their energy band gap of 3.37 eV, 1.2 eV and 3.7 eV, respectively, biocompatibility, high electron mobility, fast electron transfer rate and they are environmental-friendly in many applications. When used in sensor devices, nanomaterials have indicated high selectivity for possible use to detect the various analytes even in small volumes. Metal oxide nanostructures have shown to be good for optoelectronic nanodevices because of their electrical characteristics, high optical absorption and low-processing temperature.In this thesis, the synthesis of different morphologies of metal oxide semiconductor nanostructures and their composite using the hydrothermal method are demonstrated for various applications. This thesis is divided into three parts:In the first part of this research work, the fabrication of well-aligned ZnO nanorods using different concentrations of composite seed layer of inorganic and organic materials when using the hydrothermal growth method is presented. The effect of the composite seed layer on the i Abstract alignment, density and optical properties of the grown ZnO nanorods is investigated (paper I).Utilizing the advantage of ZnO nanostructure, a comparative study of ZnO nanorods and thin films for chemical and biosensing application was carried out. The ZnO nanorods and thin films were functionalized with strontium ionophore membrane, immobilized the galactose oxidase and lactate oxidase for determining the strontium ions, D-galactose and L-lactic acid, respectively (paper II).In the second part, the effects of different urea concentrations on the morphology of CuO nanostructures is studied as described in paper III. Moreover, CuO nanoflowers were functionalized with cadmium ion ionophore for the detection of Cd ions, while CuO nanosheets were grown by the low temperature growth method and were used for the development of a nonenzymatic glucose sensor, respectively (Paper IV).In the last part of this thesis, composite nanostructures of CuO/ZnO and NiO/ZnO were applied to develop dopamine sensor and fast sensitive UV photodetector, respectively. A nanohybrid of C...

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Section: Biosensorsmentioning

confidence: 99%

Synthesising Metal Oxide Materials and Their Composite Nanostructures for Sensing and Optoelectronic Device Applications

Khun¹

2015

Linköping Studies in Science and Technology. Dissertations

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“…They are potentially portable, simple to operate, reliable, and inexpensive to manufacture. [157][158][159][160][161][162] Many ink-type substrates have been used for sensor construction, 155,[163][164][165] the most successful have included carbon and the noble metals. Taking into consideration that carbon is inexpensive and conductive, it is the most used substrate for the economic fabrication of electrodes.…”

Section: Screen Printed Electrodesmentioning

confidence: 99%

Electrochemical sensors: a powerful tool in analytical chemistry

Stradiotto¹,

Yamanaka²,

Zanoni³

2003

J. Braz. Chem. Soc.

326

154

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Sensores potenciométricos, amperométricos e condutométricos são sensores eletroquímicos com imensa aplicação nas áreas de meio ambiente, indústria e análises clínicas. O presente trabalho apresenta uma revisão generalizada dos aspectos fundamentais, os desenvolvimento e a contribuição destes sensores na área de química analítica, e reporta alguns aspectos relevantes dos avanços na área de sensores eletroquímicos no Brasil.Potentiometric, amperometric and conductometric electrochemical sensors have found a number of interesting applications in the areas of environmental, industrial, and clinical analyses. This review presents a general overview of the three main types of electrochemical sensors, describing fundamental aspects, developments and their contribution to the area of analytical chemistry, relating relevant aspects of the development of electrochemical sensors in Brazil.

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“…A number of biosensors have been developed for in vivo measurement of biologically important compounds which are either non-electroactive or only poorly electroactive at analytically useful potentials (Turner et al, 1987;Pfeiffer and Kerner, 1988;Pantano and Kuhr, 1995). The most thoroughly investigated is the glucose biosensor incorporating the oxidoreductase enzyme, glucose oxidase (GOx).…”

Section: Introductionmentioning

confidence: 99%

An amperometric glucose-oxidase/poly(o-phenylenediamine) biosensor for monitoring brain extracellular glucose: in vivo characterisation in the striatum of freely-moving rats

Lowry

Miele

O’Neill

et al. 1998

Journal of Neuroscience Methods

100

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Amperometric glucose biosensors based on the immobilization of glucose oxidase (GOx) on Pt electrodes with electropolymerized o-phenylenediamine (PPD) were implanted in the right striatum of freely-moving rats. Carbon paste electrodes for the simultaneous monitoring of ascorbic acid (AA) and/or tissue O 2 were implanted in the left striatum. A detailed in vivo characterization of the Pt/PPD/GOx signal was carried out using various pharmacological manipulations. Confirmation that the biosensor responded to changing glucose levels in brain extracellular fluid (ECF) was obtained by intraperitoneal (i.p.) injection of insulin that caused a decrease in the Pt/PPD/GOx current, and local administion of glucose (1 mM) via an adjacent microdialysis probe that resulted in an increase in the biosensor current. An insulin induced increase in tissue O 2 in the brain was also observed. Interference studies involved administering AA and subanaesthetic doses of ketamine i.p. Both resulted in increased extracellular AA levels with ketamine also causing an increase in O 2 . No significant change in the Pt/PPD/GOx current was observed in either case indicating that changes in O 2 and AA, the principal endogenous interferents, have minimal effect on the response of these first generation biosensors. Stability tests over a successive 5-day period revealed no significant change in sensitivity. These in vivo results suggest reliable glucose monitoring in brain ECF.

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Biosensors: fundamentals and applications

Cited by 629 publications

References 0 publications

Synthesising Metal Oxide Materials and Their Composite Nanostructures for Sensing and Optoelectronic Device Applications

Synthesising Metal Oxide Materials and Their Composite Nanostructures for Sensing and Optoelectronic Device Applications

Electrochemical sensors: a powerful tool in analytical chemistry

An amperometric glucose-oxidase/poly(o-phenylenediamine) biosensor for monitoring brain extracellular glucose: in vivo characterisation in the striatum of freely-moving rats

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