Bioprospecting marine actinomycetes for multidrug-resistant pathogen control from Rameswaram coastal area, Tamil Nadu, India

Wahaab, Femina; Subramaniam, Kalidass

doi:10.1007/s00203-017-1417-7

Cited by 11 publications

(4 citation statements)

References 29 publications

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“…In medicine and pharmaceuticals, DSI has been instrumental in the research and development of drugs and vaccines and the design of diagnostic reagents for infectious diseases (Buenz et al, 2018; Guzzetti et al, 2018; Tiwari et al, 2018; Wahaab & Subramaniam, 2018). The DSI of infectious disease pathogens can stimulate R&D related to vaccines without obtaining the substance (Donner, 2013).…”

Section: The Value Of Dsi and The Need For Global Governancementioning

confidence: 99%

Global governance for digital sequence information on genetic resources: Demand, progress and reforming paths

Qin

2023

Global Policy

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The cross‐border transmission of digital sequence information (DSI) on genetic resources is an emerging global governance issue, particularly since its inclusion in the post‐2020 framework of the Convention on Biological Diversity. Based on a brief review of the value of DSI and the need for global governance, this paper identifies three elemental regimes on ‘physical’ genetic resources that are in conflict: divergent principles of sovereignty claim, global multilateral sharing and intellectual property rights protection. It then traces the progress of each elemental regime on DSI and describes their ongoing conflicts. Two reform strategies for better governance are suggested: one gradual and path‐dependent and one more radical. The basis of the radical strategy is to promote labour division and cooperation among institutions of different elemental regimes within a three‐layered system of DSI values.

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Section: The Value Of Dsi and The Need For Global Governancementioning

confidence: 99%

Global governance for digital sequence information on genetic resources: Demand, progress and reforming paths

Qin

2023

Global Policy

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“…Several potential antimicrobial compounds were also extracted from the isolate viz. 1,4-benzenediol, 2,6-di- tert -butylphenol and 1 H, 5 H, pyrrolo (1′ 2′:3, 4) imidazo [ 25 ]. 37 actinomycetes strains were isolated from the sediment sample of Kovalam coast, out of which 10 isolates possessed antagonistic activities against all the five test organisms ( Escherichia coli, Klebsiella sp., Pseudomonas sp., Enterococcus sp., Proteus sp. )…”

Section: Actinomycetes Isolated From the Different Marine Environmentmentioning

confidence: 99%

“…It could be used in the development of new substances for industrial applications [ 36 ]. Different antibacterial compounds such as 1,4-benzenediol, 2,6-di-tert-butylphenol, and 1 H, 5 H, pyrrolo (1′ 2′:3, 4) imidazo were obtained from Streptomyces bacillaris RAM25C4 [ 25 ]. Kocuria sp.…”

Section: Secondary Metabolites and Bioactivity By Actinomycetesmentioning

confidence: 99%

Diversity and Biotechnological Potential of Marine Actinomycetes from India

Sarkar

Suthindhiran

2022

Indian J Microbiol

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Actinomycetes are potential antibiotic producers that have been isolated from various terrestrial ecosystems and are exploited for their bioactive compounds. On the contrary, the marine environments were less explored and the research on marine actinomycetes had gained momentum only for the past three decades. Marine actinomycetes are one of the most significant producers of diverse groups of secondary metabolites and provide a huge scope for pharmaceutical and other industries. These organisms are proved to be important, both biotechnologically and economically considering their global presence. The marine ecosystem in India is less explored for the isolation of actinomycetes and several ecological niches are left unattended. Compared to the global scenario, the contribution from Indian researchers towards the isolation and exploitation of marine actinomycetes from the Indian sub-continent is noteworthy. Exploration of actinomycetes from these ecosystems will certainly yield new species and metabolites. Considering the declining rate of drug discovery from terrestrial actinomycetes, the marine counterparts, especially from unexplored regions from the Indian coast will hold a promising way ahead. Apart from drugs, these organisms are reported for the production of different industrially important enzymes like cellulase, amylase, protease, lipase, etc. They are also used in environmental applications, agriculture, and aquacultures sectors. With the rapid advancement in the study of actinomycetes from different marine sources in India, new metabolites are being discovered which have an important role from the economic and industrial point of view. As the world is witnessing newer diseases such as Sars-Cov 2 and the pandemic due to its demands drugs and other metabolites are increasing day by day. Therefore, the necessity for the quest for unique and rare marine actinomycetes is enhancing too. This review highlights the research on marine actinomycetes in India and also the challenges associated with its research.

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“…Table S4: Antimicrobial activity of actinobacterial crude extracts or compounds presented through inhibition zone (mm). References [ 185 , 186 , 187 , 188 , 189 , 190 , 191 , 192 , 193 , 194 , 195 , 196 , 197 , 198 , 199 , 200 , 201 , 202 , 203 , 204 , 205 , 206 , 207 , 208 , 209 , 210 , 211 , 212 , 213 , 214 , 215 ] are cited in the supplementary tables.…”

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confidence: 99%

Marine Actinobacteria a New Source of Antibacterial Metabolites to Treat Acne Vulgaris Disease—A Systematic Literature Review

2022

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Acne vulgaris is a multifactorial disease that remains under-explored; up to date it is known that the bacterium Cutibacterium acnes is involved in the disease occurrence, also associated with a microbial dysbiosis. Antibiotics have become a mainstay treatment generating the emergence of antibiotic-resistant bacteria. In addition, there are some reported side effects of alternative treatments, which indicate the need to investigate a different therapeutic approach. Natural products continue to be an excellent option, especially those extracted from actinobacteria, which represent a prominent source of metabolites with a wide range of biological activities, particularly the marine actinobacteria, which have been less studied than their terrestrial counterparts. Therefore, this systematic review aimed to identify and evaluate the potential anti-infective activity of metabolites isolated from marine actinobacteria strains against bacteria related to the development of acne vulgaris disease. It was found that there is a variety of compounds with anti-infective activity against Staphylococcus aureus and Staphylococcus epidermidis, bacteria closely related to acne vulgaris development; nevertheless, there is no report of a compound with antibacterial activity or quorum-sensing inhibition toward C. acnes, which is a surprising result. Since two of the most widely used antibiotics for the treatment of acne targeting C. acnes were obtained from actinobacteria of the genus Streptomyces, this demonstrates a great opportunity to pursue further studies in this field, considering the potential of marine actinobacteria to produce new anti-infective compounds.

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Bioprospecting marine actinomycetes for multidrug-resistant pathogen control from Rameswaram coastal area, Tamil Nadu, India

Cited by 11 publications

References 29 publications

Global governance for digital sequence information on genetic resources: Demand, progress and reforming paths

Global governance for digital sequence information on genetic resources: Demand, progress and reforming paths

Diversity and Biotechnological Potential of Marine Actinomycetes from India

Marine Actinobacteria a New Source of Antibacterial Metabolites to Treat Acne Vulgaris Disease—A Systematic Literature Review

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