Marine Actinobacteria a New Source of Antibacterial Metabolites to Treat Acne Vulgaris Disease—A Systematic Literature Review

Abstract

Acne vulgaris is a multifactorial disease that remains under-explored; up to date it is known that the bacterium Cutibacterium acnes is involved in the disease occurrence, also associated with a microbial dysbiosis. Antibiotics have become a mainstay treatment generating the emergence of antibiotic-resistant bacteria. In addition, there are some reported side effects of alternative treatments, which indicate the need to investigate a different therapeutic approach. Natural products continue to be an excellent option, especially those extracted from actinobacteria, which represent a prominent source of metabolites with a wide range of biological activities, particularly the marine actinobacteria, which have been less studied than their terrestrial counterparts. Therefore, this systematic review aimed to identify and evaluate the potential anti-infective activity of metabolites isolated from marine actinobacteria strains against bacteria related to the development of acne vulgaris disease. It was found that there is a variety of compounds with anti-infective activity against Staphylococcus aureus and Staphylococcus epidermidis, bacteria closely related to acne vulgaris development; nevertheless, there is no report of a compound with antibacterial activity or quorum-sensing inhibition toward C. acnes, which is a surprising result. Since two of the most widely used antibiotics for the treatment of acne targeting C. acnes were obtained from actinobacteria of the genus Streptomyces, this demonstrates a great opportunity to pursue further studies in this field, considering the potential of marine actinobacteria to produce new anti-infective compounds.

Diversity and Antimicrobial Activities of Actinobacteria Isolated from Mining Soils in Midelt Region, Morocco

“…Resistance to antibiotics remains a serious global health issue, and there is an urgent need for novel and effective antibiotics. By the end of the last century, despite the extensive efforts in screening soil-dwelling Actinobacteria for new bioactive compounds for pharmaceutical use, most attempts went in vain [ 12 ]. As a result, investigating Actinobacteria living in unexplored habitats such as desert soils, marine biotopes, saline environments, and other extreme environments, in which certain physical and/or chemical factors differ significantly from those in natural and well-studied habitats, has shown great importance because of the novelty of their antimicrobial compounds [ 13 , 14 ].…”

Discovery of antimalarial drugs from secondary metabolitesin actinomycetes culture library

“…Over the last four decades, almost 50% of all antimicrobials were discovered from natural products [18]. Approximately, 70% of the known antibiotic are derived from Streptomyces [19]. Currently, the World Health Organization (WHO) recommends the combination of actinomycetes-derived doxycycline and sulfadoxine-pyrimethamine for travelers to prevent malaria [1].…”

LogoMotif: a comprehensive database of transcription factor binding site profiles in Actinobacteria

“…Actinobacteria are one of the largest bacterial phyla and known as Nature's medicine makers [1,2]. Actinobacteria produce some two thirds of all known antibiotics and many other bioactive molecules of medical, agricultural and biotechnological importance [3,4]. Their ubiquitous presence in diverse ecosystems, both aquatic and terrestrial, necessitates their ability to rapidly perceive and respond to environmental changes [5,6].…”