Bioprocess strategies and recovery processes in gibberellic acid fermentation

Shukla, Ruchi; Srivastava, Ashok K.; Chand, Subhash

doi:10.1007/bf02949216

Cited by 26 publications

(16 citation statements)

References 81 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The production phase is preceded by the formation of anthraquinone, bikaverin and fusarin C along with GA 3 . Among these secondary metabolites, bikaverin is the main undesirable by-product of GA 3 fermentation and complicates its purification from fermentation media (Tudzynski, 1999;Linnemannstons et al, 2002;Shukla, Srivastava and Chand, 2003;Limón, Rodríguez-Ortiz and Avalos, 2010). Thus, it is desirable to limit the production of bikaverin in order to enhance the yield and productivity of GA 3 .…”

Section: Biosynthesis Pathwaymentioning

confidence: 98%

See 1 more Smart Citation

New perspectives of gibberellic acid production: a review

Rodrigues

Vandenberghe

Oliveira

et al. 2011

Critical Reviews in Biotechnology

View full text Add to dashboard Cite

The gibberellins (GAs) are an important group of hormones which exert various effects on promoter and regulator of plant growth. Gibberellic acid (GA(3)) is a natural plant hormone, with great economical and industrial importance. It affects stem elongation, germination, elimination of dormancy, flowering, sex expression, enzyme induction and leaf and fruit senescence. Despite its diverse applications, the use of GA(3) is limited due to its high production costs. The industrial process currently used for the production of GA(3) is based on submerged fermentation (SmF) techniques. As an alternative for its production, solid state fermentation (SSF) has also been investigated for its ability to increase the yields of GA(3) with the use of agro-industrial wastes as support/substrate, which contributes to the decreased production costs. This review describes GA(3)'s physical, chemical and biological properties, its production by fermentation and new advances that are being carried out with special interest on the SSF technique.

show abstract

Section: Biosynthesis Pathwaymentioning

confidence: 98%

“…production, like that of several other secondary metabolites, is initiated by the depletion of the nitrogen source from the medium (Shukla Srivastava and Chand, 2003). The production phase is preceded by the formation of anthraquinone, bikaverin and fusarin C along with GA 3 .…”

Section: Biosynthesis Pathwaymentioning

confidence: 99%

New perspectives of gibberellic acid production: a review

Rodrigues

Vandenberghe

Oliveira

et al. 2011

Critical Reviews in Biotechnology

View full text Add to dashboard Cite

show abstract

“…Milk permeate, a dairy by‐product, is a cheap carbon source that is rich in lactose and minerals, but low in nitrogen . For gibberellic acid production, it is necessary to limit the nitrogen source in the growth medium . Considering these aspects, Fusarium moniliforme was immobilized on loofa sponge for gibberellic acid biosynthesis from milk permeate in repeated batch cycles, which resulted in 2.4 g gibberellic acid/L of the peremeate, more than 2.8‐times greater than produced by free cells, with the possibility of four repeated cycles.…”

Section: Developments Of Cells Entrapment In Loofa Sponge For Differementioning

confidence: 99%

Loofa (Luffa cylindrica) sponge: Review of development of the biomatrix as a tool for biotechnological applications

Saeed¹,

Iqbal²

2013

Biotechnology Progress

100

View full text Add to dashboard Cite

The review discusses the development of loofa sponge (Luffa cylindrica) as a biotechnological tool and the diversity of applications in which it has been successfully used since it was first reported as a matrix for the immobilization of microbiological cells in 1993. The fibro-vascular reticulated structure, made up of an open network of random lattices of small cross-sections coupled with very high porosity (79-93%), having very low density (0.02-0.04 g/cm(3) ), and high specific pore volume (21-29 cm(3) /g), has the characteristics of a carrier/scaffold well-suited for cell immobilization. This has been confirmed through the immobilization of cells of diverse types, including filamentous and microalgae, fungi, bacteria, yeasts, higher plants, and human and rat hepatocytes. The cells immobilized in loofa sponge have performed well and better than free suspended cells and those immobilized in conventionally used natural and synthetic polymeric materials for the production of ethanol, organic acids, enzymes, and secondary metabolites. The loofa-immobilized cell systems have been efficiently used for the treatment of wastewaters containing toxic metals, dyes, and chlorinated compounds, and the technology has been used to develop biofilms for the remediation of domestic and industrial wastewaters rich in inorganic and organic matter. In addition, three-dimensional loofa sponge scaffolds for hepatocyte culture have been suggested to have the potential for development into a bioartificial liver device. Loofa sponge is a cost-effective, eco-friendly, and easy to handle matrix that has been used successfully as a biotechnological tool in a variety of systems, purposes, and applications.

show abstract

“…With regards to the production process of gibberellins there are many points to study. To date, more than 126 GAs have been identified from these natural sources (Tudzynski 1999;Shukla et al 2003). Some of these GAs act as natural plant hormones, controlling developmental processes such as the induction of hydrolytic enzyme activity during seed germination, stem elongation, flower induction and pericarp growth (Rojas et al 2001).…”

Section: Introductionmentioning

confidence: 99%

Inductive effect produced by a mixture of carbon source in the production of gibberellic acid by Gibberella fujikuroi

Rios‐Iribe

Flores-Cotera

Chavira

et al. 2010

World J Microbiol Biotechnol

View full text Add to dashboard Cite

Gibberellic acid has been known since 1954 but its effect on rice still remains very important in the agricultural world. Gibberellic acid (GA3) is the main secondary metabolite produced by the Gibberella fujikuroi fungus. This hormone is of great importance in agriculture and the brewing industry, due to its fast and strong effects at low concentrations (μg) on the processes of growth stimulation, flowering, stem elongation, and germination of seeds, among others. Plant promoters of growth production such as the gibberellins, especially the GA3 are a priority in obtaining better harvests in the agricultural area and by extension, improving the food industry. Three routes to obtaining GA3 have been reported: extraction from plants, chemical synthesis and microbial fermentation. The latter being the most common method used to produce GA3. In this investigation, glucose-corn oil mixture was used as a carbon source on the basis of 40 g of carbon in a 7 L stirred tank bioreactor. A pH of 3.5, 29°C, 600 min(-1) agitation and 1 vvm aeration were maintained and controlled with a biocontroller connected to the bioreactor, throughout the entire culture time. The carbon source mixture affected the fermentation time as well as the production of the GAs. The production of 380 mg GA3L(-1) after 288 h of fermentation was obtained when the glucose-corn oil mixture was employed contrasting the 136 mg GA3L(-1) at 264 h of culture when only glucose was used.

show abstract

Bioprocess strategies and recovery processes in gibberellic acid fermentation

Cited by 26 publications

References 81 publications

New perspectives of gibberellic acid production: a review

New perspectives of gibberellic acid production: a review

Loofa (Luffa cylindrica) sponge: Review of development of the biomatrix as a tool for biotechnological applications

Inductive effect produced by a mixture of carbon source in the production of gibberellic acid by Gibberella fujikuroi

Contact Info

Product

Resources

About