New perspectives of gibberellic acid production: a review

Rodrigues, Cristine; Vandenberghe, Luciana Porto de Souza; Oliveira, Juliana de; Soccol, Carlos Ricardo

doi:10.3109/07388551.2011.615297

Cited by 97 publications

(57 citation statements)

References 126 publications

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“…Gibberellic acid ( G , Figure 2) is a plant hormone isolated from Gibberella fujikuroi 22 and produced industrially 23 on the ton scale. Gibberellic acid contains a tetracyclic diterpene core with a fused lactone, two allylic alcohols, an exocyclic olefin, and a carboxylic acid, enabling selective and independent functionalization of each ring of the core structure via a variety of ring system distortion reactions.…”

Section: Resultsmentioning

confidence: 99%

A ring-distortion strategy to construct stereochemically complex and structurally diverse compounds from natural products

Huigens

Morrison²,

Hicklin³

et al. 2013

Nature Chem

288

253

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High-throughput screening is the dominant method to identify lead compounds in drug discovery. As such, the makeup of screening libraries will largely dictate the biological targets that can be modulated and the therapeutics that can be developed. Unfortunately, most compound screening collections consist principally of planar molecules with little structural or stereochemical complexity, compounds that do not offer the arrangement of chemical functionality necessary for modulation of many drug targets. Here we describe a novel, general, and facile strategy for the creation of diverse compounds with high structural and stereochemical complexity using readily available natural products as synthetic starting points. We show, through evaluation of chemical properties including fraction of sp3 carbons, ClogP, and the number of stereogenic centers, that these compounds are significantly more complex and diverse than those in standard screening collections, and guidelines are given for the application of this strategy to any suitable natural product.

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Section: Resultsmentioning

confidence: 99%

A ring-distortion strategy to construct stereochemically complex and structurally diverse compounds from natural products

Huigens

Morrison²,

Hicklin³

et al. 2013

Nature Chem

288

253

View full text Add to dashboard Cite

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“…GAs comprises a group of growth hormones that control diverse processes, such as cell elongation, reproductive growth and senescence [54]. Previous reports showed that GAs are inhibitors of leaf senescence [55,56].…”

Section: Resultsmentioning

confidence: 99%

Global analysis of the Gossypium hirsutum L. Transcriptome during leaf senescence by RNA-Seq

et al. 2015

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Background: Leaf senescence is an important developmental programmed degeneration process that dramatically affects crop quality and yield. The regulation of senescence is highly complex. Although senescence regulatory genes have been well characterized in model species such as Arabidopsis and rice, there is little information on the control of this process in cotton. Here, the senescence process in cotton (Gossypium hirsutum L.) leaves was investigated over a time course including young leaf, mature leaf and leaf samples from different senescence stages using RNA-Seq.

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“…GA is a pentacyclic diterpene which influences the (1) cell elongation, (2) dormancy, (3) seed germination, (4) senescence, and (5) tolerance against environmental stresses (Rodrigues et al 2011). Actually, no data on the action of exogenously applying GA to plants neither the effect of O 3 on GA biosynthesis and signaling pathway are found in literature despite its prominent role in the mitigation of environmental stresses.…”

Section: Gibberellins (Gas) Auxins (Iaas) and Cytokinins (Cks)mentioning

confidence: 95%

Involvement of Phytohormones in Plant Responses to Ozone

Pellegrini

Trivellini

Cotrozzi

et al. 2016

Plant Hormones Under Challenging Environmental Factors

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Among various contaminants, ozone (O 3 ) is considered the most ubiquitous and phytotoxic atmospheric pollutant in industrialized and developing countries. It causes extensive risks for plant life, in terms of survival and productivity of wild and cultivated species. Plant response to O 3 resembles the biotic defense reactions and includes two steps: the first is a biphasic oxidative burst with a massive, rapid, and transient increase in apoplastic reactive oxygen species (ROS) production; the second is the induction of the hypersensitive response (HR) and systemic acquired resistance (SAR). In particular, the acute O 3 exposure (high concentrations for a few hours) results in the activation of programmed cell death (PCD) response that interacts with the synthesis of several hormones and other signaling molecules. The cross talk among all these molecules and their complex and interconnected signaling pathways are more important to determine (1) the initiation, propagation, and containment of O 3 -induced cell death, (2) the degree of the sensitivity of plants to this contaminant, and (3) the regulatory potential that plants have to promptly respond to oxidative stress. The present chapter reviews the role of phytohormones (such as ethylene, abscisic acid, gibberellins, auxins, and cytokinins) and other signaling molecules (such as salicylic and jasmonic acids, proline, and brassinosteroids), as well as their synergistic and antagonistic effects, in the complex signaling pathway involved in plant responses to O 3 stress.

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New perspectives of gibberellic acid production: a review

Cited by 97 publications

References 126 publications

A ring-distortion strategy to construct stereochemically complex and structurally diverse compounds from natural products

A ring-distortion strategy to construct stereochemically complex and structurally diverse compounds from natural products

Global analysis of the Gossypium hirsutum L. Transcriptome during leaf senescence by RNA-Seq

Involvement of Phytohormones in Plant Responses to Ozone

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