Bioprinting on sheet-based scaffolds applied to the creation of implantable tissue-engineered constructs with potentially diverse clinical applications: Tissue-Engineered Muscle Repair (TEMR) as a representative testbed

Bour, R. K.; Sharma, Poonam; Turner, Jonathan S.; Hess, W. E.; Mintz, Ellen L.; Latvis, C. R.; Shepherd, Benjamin R.; Presnell, Sharon C.; McConnell, M. J.; Highley, Christopher B.; Peirce, Shayn M.; Christ, George J.

doi:10.1080/03008207.2019.1679800

Cited by 13 publications

(6 citation statements)

References 54 publications

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“…[81] Progenitor cells seeded in dECM-based hydrogel. [121] Primary human airway and intestinal smooth muscle cells seeded in alginate-based matrix with either collagen or intestinal dECM. [125] Bone tissue Alginate-gelatin-agarose hydrogel laden with SaOS-2 cells.…”

Section: Skin Tissuementioning

confidence: 99%

“…Additionally, compatible with extrusion bioprinting are the coaxial and multi-material techniques, suitable for different sorts of applications. However, in general, the extrusion bioprinting approach has been used to fabricate 3D tissues and biological constructs including kidney [ 89 ], liver [ 98 ], blood vessels [ 93 ], tissue-engineered muscle [ 121 ], human intestinal tissue [ 97 ], adipose tissues [ 95 , 96 ], tracheal graft [ 37 ], tooth tissue [ 122 ], vascularized soft tissues [ 123 ], skin constructs [ 92 ], engineered neural tissues [ 126 ], brain tissue [ 127 ], renal tissue [ 128 ], cartilage tissue constructs [ 50 , 137 , 143 ], bone tissue [ 85 ] and other engineered structures [ 103 , 104 ].…”

Section: 3d Bioprinting and Process Parametersmentioning

confidence: 99%

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Natural Hydrogel-Based Bio-Inks for 3D Bioprinting in Tissue Engineering: A Review

Fatimi

Okoro

Podstawczyk

et al. 2022

Gels

123

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Three-dimensional (3D) printing is well acknowledged to constitute an important technology in tissue engineering, largely due to the increasing global demand for organ replacement and tissue regeneration. In 3D bioprinting, which is a step ahead of 3D biomaterial printing, the ink employed is impregnated with cells, without compromising ink printability. This allows for immediate scaffold cellularization and generation of complex structures. The use of cell-laden inks or bio-inks provides the opportunity for enhanced cell differentiation for organ fabrication and regeneration. Recognizing the importance of such bio-inks, the current study comprehensively explores the state of the art of the utilization of bio-inks based on natural polymers (biopolymers), such as cellulose, agarose, alginate, decellularized matrix, in 3D bioprinting. Discussions regarding progress in bioprinting, techniques and approaches employed in the bioprinting of natural polymers, and limitations and prospects concerning future trends in human-scale tissue and organ fabrication are also presented.

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Section: Skin Tissuementioning

confidence: 99%

Section: 3d Bioprinting and Process Parametersmentioning

confidence: 99%

Natural Hydrogel-Based Bio-Inks for 3D Bioprinting in Tissue Engineering: A Review

Fatimi

Okoro

Podstawczyk

et al. 2022

Gels

123

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“… 41 Bour et al demonstrate a tissue-engineered muscle repair (TEMR) system, where extrusion printing of HA-cell-laden bioink onto both sides of bladder acellular matrix scaffold creates potentially scalable cell sheets. 42 Although this method is viable for upscaling, true 3D control is lacking.…”

Section: Printing and Seeding Constructsmentioning

confidence: 99%

Replace and repair: Biomimetic bioprinting for effective muscle engineering

Massey

Boyd‐Moss

et al. 2021

APL Bioengineering

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The debilitating effects of muscle damage, either through ischemic injury or volumetric muscle loss (VML), can have significant impacts on patients, and yet there are few effective treatments. This challenge arises when function is degraded due to significant amounts of skeletal muscle loss, beyond the regenerative ability of endogenous repair mechanisms. Currently available surgical interventions for VML are quite invasive and cannot typically restore function adequately. In response to this, many new bioengineering studies implicate 3D bioprinting as a viable option. Bioprinting for VML repair includes three distinct phases: printing and seeding, growth and maturation, and implantation and application. Although this 3D bioprinting technology has existed for several decades, the advent of more advanced and novel printing techniques has brought us closer to clinical applications. Recent studies have overcome previous limitations in diffusion distance with novel microchannel construct architectures and improved myotubule alignment with highly biomimetic nanostructures. These structures may also enhance angiogenic and nervous ingrowth post-implantation, though further research to improve these parameters has been limited. Inclusion of neural cells has also shown to improve myoblast maturation and development of neuromuscular junctions, bringing us one step closer to functional, implantable skeletal muscle constructs. Given the current state of skeletal muscle 3D bioprinting, the most pressing future avenues of research include furthering our understanding of the physical and biochemical mechanisms of myotube development and expanding our control over macroscopic and microscopic construct structures. Further to this, current investigation needs to be expanded from immunocompromised rodent and murine myoblast models to more clinically applicable human cell lines as we move closer to viable therapeutic implementation.

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“…Therefore, wound‐closing and cavity filling are necessary. As a powerful biomaterial, hydrogel is reported to be extensively utilized in tissue engineering, including skin, 171 bone, 172,173 cartilage, 174,175 muscle, 176,177 adipose tissue, 178 and so on. For tissue repair after cancer treatment, we summarized some representative examples here in (Table 3).…”

Section: The Application Of Hydrogels In Localized Tumor Treatmentmentioning

confidence: 99%

Advances and trends of hydrogel therapy platform in localized tumor treatment: A review

Tan

Huang

et al. 2020

J Biomedical Materials Res

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Due to limitations of treatment and the stubbornness of infiltrative tumor cells, the outcome of conventional antitumor treatment is often compromised by a variety of factors, including severe side effects, unexpected recurrence, and massive tissue loss during the treatment. Hydrogel‐based therapy is becoming a promising option of cancer treatment, because of its controllability, biocompatibility, high drug loading, prolonged drug release, and specific stimuli‐sensitivity. Hydrogel‐based therapy has good malleability and can reach some areas that cannot be easily touched by surgeons. Furthermore, hydrogel can be used not only as a carrier for tumor treatment agents, but also as a scaffold for tissue repair. In this review, we presented the latest researches in hydrogel applications of localized tumor therapy and highlighted the recent progress of hydrogel‐based therapy in preventing postoperative tumor recurrence and improving tissue repair, thus proposing a new trend of hydrogel‐based technology in localized tumor therapy. And this review aims to provide a novel reference and inspire thoughts for a more accurate and individualized cancer treatment.

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Bioprinting on sheet-based scaffolds applied to the creation of implantable tissue-engineered constructs with potentially diverse clinical applications: Tissue-Engineered Muscle Repair (TEMR) as a representative testbed

Cited by 13 publications

References 54 publications

Natural Hydrogel-Based Bio-Inks for 3D Bioprinting in Tissue Engineering: A Review

Natural Hydrogel-Based Bio-Inks for 3D Bioprinting in Tissue Engineering: A Review

Replace and repair: Biomimetic bioprinting for effective muscle engineering

Advances and trends of hydrogel therapy platform in localized tumor treatment: A review

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