Bioprinting of Blood Vessels

Melchiorri, Anthony J.; Fisher, John P.

doi:10.1016/b978-0-12-800972-7.00020-7

Cited by 11 publications

(10 citation statements)

References 80 publications

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“…These unique features provide several advantages over other conventional processes. However, bioprinted grafts made from hydrogels are very fragile and have insufficient strength to withstand hemodynamic pressures in vivo [118].…”

Section: Discussionmentioning

confidence: 99%

Vascular Graft Infections: An Overview of Novel Treatments Using Nanoparticles and Nanofibers

Serpelloni

Alvear

et al. 2022

Fibers

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Vascular disease in elderly patients is a growing health concern, with an estimated prevalence of 15–20% in patients above 70 years old. Current treatment for vascular diseases requires the use of a vascular graft (VG) to revascularize lower or upper extremities, create dialysis access, treat aortic aneurysms, and repair dissection. However, postoperative infection is a major complication associated with the use of these VG, often necessitating several operations to achieve complete or partial graft excision, vascular coverage, and extra-anatomical revascularization. There is also a high risk of morbidity, mortality, and limb loss. Therefore, it is important to develop a method to prevent or reduce the incidence of these infections. Numerous studies have investigated the efficacy of antibiotic- and antiseptic-impregnated grafts. In comparison to these traditional methods of creating antimicrobial grafts, nanotechnology enables researchers to design more efficient VG. Nanofibers and nanoparticles have a greater surface area compared to bulk materials, allowing for more efficient encapsulation of antibiotics and better control over their temporo-spatial release. The disruptive potential of nanofibers and nanoparticles is exceptional, and they could pave the way for a new generation of prosthetic VG. This review aims to discuss how nanotechnology is shaping the future of cardiovascular-related infection management.

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Section: Discussionmentioning

confidence: 99%

Vascular Graft Infections: An Overview of Novel Treatments Using Nanoparticles and Nanofibers

Serpelloni

Alvear

et al. 2022

Fibers

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“…Amongst them, the principal advantage of bioprinting lies in the ability to directly fabricate heterocellular tissue constructs with ease of modulation of cell densities. This advantage is driving researchers to explore 3D bioprinting techniques at deeper scales to solve the vascularization problem in tissue engineering [68].…”

Section: Need For the Vascular Tissue Towards Fabrication Of Tissues mentioning

confidence: 99%

Bioprinting for vascular and vascularized tissue biofabrication

2017

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Biofabrication of living tissues and organs at the clinically-relevant volumes vitally depends on the integration of vascular network. Despite the great progress in traditional biofabrication approaches, building perfusable hierarchical vascular network is a major challenge. Bioprinting is an emerging technology to fabricate design-specific tissue constructs due to its ability to create complex, heterocellular structures with anatomical precision, which holds a great promise in fabrication of vascular or vascularized tissues for transplantation use. Although a great progress has recently been made on building perfusable tissues and branched vascular network, a comprehensive review on the state-of-the-art in vascular and vascularized tissue bioprinting has not reported so far. This contribution is thus significant because it discusses the use of three major bioprinting modalities in vascular tissue biofabrication for the first time in the literature and compares their strengths and limitations in details. Moreover, the use of scaffold-based and scaffold-free bioprinting is expounded within the domain of vascular tissue fabrication.

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“…Upon implantation, the 3D-printed vascular structures enabled cell differentiation and survival, increased vascularization, and recovery of ischemic limbs [ 65 , 66 ]. The success of the final application of 3D constructions is the result of choices related to some previously mentioned factors, such as cell type and the material properties, as well as specific characteristics of 3D technology, such as the bioprinting approach, process parameters, and 3D-printed architecture [ 68 ]. This section and Table S3 (supplementary material) summarize the technological approach and features applied to newly engineered vasculature biostructures produced by different 3D-printing techniques, including inkjet, layer-by-layer and thermal extrusion, stereolithography or digital light processing, and photodegradation.…”

Section: Encapsulation Technologies For Angiogenic Therapymentioning

confidence: 99%