Trends in hydrogel-based encapsulation technologies for advanced cell therapies applied to limb ischemia

Costa, Ana Letícia Rodrigues; Willerth, Stephanie M.; Torre, Lucimara Gaziola de la; Han, Sang Won

doi:10.1016/j.mtbio.2022.100221

Cited by 8 publications

(8 citation statements)

References 96 publications

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“…Likewise, Costa et al (2022) investigated that the larger particles with higher porosity would allow hydrogel to leak the drug, resulting in faster release rates. Because of ECs hydrophobic and plastic nature, the particles adjacent to the surface matrix may initially be released resulting in an initial burst effect [24]. There are three factors has been selected considering the various factor and level.…”

Section: Ps Drug Release and Optimizationmentioning

confidence: 99%

Application of 32 Factorial Design of Loratadine-Loaded Nanosponge in Topical Gel system: In Vitro, Ex Vivo, and In Vivo Assessments

Sivadasan,

Venkatesan,

Mohamed

et al. 2024

Preprint

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Loratadine (LoR) is a highly lipophilic and practically insoluble in water, hence having a low oral bioavailability. As it is formulated as topical gel, it competitively binds with the receptors, thus reducing the side-effects. The objective of this study was to prepare LoR loaded nanosponge (LoR-NS) in gel for topical delivery. Nine different formulations of emulsion were prepared by solvent evaporation method with polyvinyl alcohol (PVA), ethyl cellulose (EC), and dichloromethane (DCM). Based on 32 Full Factorial Design (FFD), optimization was carried out by varying the concentration of LOR:EC ratio and stirring rate. The preparations were subjected for the evaluation of particle size (PS), in vitro release, zeta potential (ZP) and entrapment efficiency (EE). The results revealed that the NS dispersion was nanosized with sustained release profiles and significant PS. The optimized formulation was formulated and incorporated into carbopol 934P hydrogel. The formulation was then examined to surface morphological characterizations using scanning electron microscopy (SEM) which depicted spherical NS. Stability studies, undertaken for 2 months at 40 ± 2 ℃ and 75 ± 5% RH, concluded to the stability of the formulation. The formulation did not cause skin irritation. Therefore, the prepared NS hydrogel proved to be a promising applicant for LoR as a novel drug delivery system (NDDS) for safe, sustained and controlled topical application.

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Section: Ps Drug Release and Optimizationmentioning

confidence: 99%

Application of 32 Factorial Design of Loratadine-Loaded Nanosponge in Topical Gel system: In Vitro, Ex Vivo, and In Vivo Assessments

Sivadasan,

Venkatesan,

Mohamed

et al. 2024

Preprint

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“…Some examples are wound healing, tissue engineering, cell proliferation, and drug delivery. [38][39][40] Despite being highly attractive thanks to the abovementioned properties, hydrogels still lack multifunctionality, in terms of stimuli-responsiveness or additional functions, poor mechanical properties and scarce interaction with hydrophobic substances. For this reason, the scientific community has started to turn its attention to the development of hydrogel-based systems capable of overcoming these intrinsic limits.…”

Section: Hydrogels: Main Properties and Current Limitationsmentioning

confidence: 99%

“…Hydrogels have found applications in many fields, especially in the biomedical one. Some examples are wound healing, tissue engineering, cell proliferation, and drug delivery [38–40] . Despite being highly attractive thanks to the abovementioned properties, hydrogels still lack multifunctionality, in terms of stimuli‐responsiveness or additional functions, poor mechanical properties and scarce interaction with hydrophobic substances.…”

Section: Hydrogels: Main Properties and Current Limitationsmentioning

confidence: 99%

Last Advances on Hydrogel Nanoparticles Composites in Medicine: An Overview with Focus on Gold Nanoparticles

Molinelli,

Schirato,

Moretti

et al. 2024

ChemNanoMat

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Hydrogel nanocomposites have lately taken part in the biomaterials scenario for several applications in the biomedical field, e.g., drug delivery, biosensing and cancer therapy. The inclusion of a broad variety of nanomaterials inside the hydrogel matrix leads to the successful development of hybrid platforms with superior and advantageous features. In this way, finely designed nano‐systems can be obtained, which are able to overcome the intrinsic limitations of conventional hydrogels, such as weak mechanical properties, burst drug delivery, extremely high hydrophilicity and lack of multifunctionality. This review aims to outline the last advances in the manufacturing of nanocomposite systems and their novel applications to the biomedical field, providing an overview of the most used nanoparticles with a special focus on gold nanoparticles.

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“…Along with these changes, excessive collagen fiber deposition was reduced after the transplantation of hydrogel to the target sites [ 271 ]. In a study (phase I–IIa), gelatin microspheres were transplanted as a therapeutic angiogenesis system to 10 patients with CLI [ 272 ]. To this end, patients [with arteriosclerosis obliterans ( n = 7) or thromboangiitis obliterans (n = 3)] received a 200-μg intramuscular injection of bFGF/gelatin hydrogel microspheres.…”

Section: Induction Of Angiogenesis Using Scaffolds For Muscle Regener...mentioning

confidence: 99%

“…To this end, patients [with arteriosclerosis obliterans ( n = 7) or thromboangiitis obliterans (n = 3)] received a 200-μg intramuscular injection of bFGF/gelatin hydrogel microspheres. Based on the obtained data, transcutaneous oxygen pressure was meaningfully improved in both subgroups 4 and 24 weeks after treatment, indicating the angiogenesis potential of gelatin hydrogel with sustained bFGF release into the muscular mass [ 272 ].…”

Section: Induction Of Angiogenesis Using Scaffolds For Muscle Regener...mentioning

confidence: 99%

Tissue engineering modalities in skeletal muscles: focus on angiogenesis and immunomodulation properties

et al. 2023

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Muscular diseases and injuries are challenging issues in human medicine, resulting in physical disability. The advent of tissue engineering approaches has paved the way for the restoration and regeneration of injured muscle tissues along with available conventional therapies. Despite recent advances in the fabrication, synthesis, and application of hydrogels in terms of muscle tissue, there is a long way to find appropriate hydrogel types in patients with congenital and/or acquired musculoskeletal injuries. Regarding specific muscular tissue microenvironments, the applied hydrogels should provide a suitable platform for the activation of endogenous reparative mechanisms and concurrently deliver transplanting cells and therapeutics into the injured sites. Here, we aimed to highlight recent advances in muscle tissue engineering with a focus on recent strategies related to the regulation of vascularization and immune system response at the site of injury.

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Trends in hydrogel-based encapsulation technologies for advanced cell therapies applied to limb ischemia

Cited by 8 publications

References 96 publications

Application of 32 Factorial Design of Loratadine-Loaded Nanosponge in Topical Gel system: In Vitro, Ex Vivo, and In Vivo Assessments

Application of 32 Factorial Design of Loratadine-Loaded Nanosponge in Topical Gel system: In Vitro, Ex Vivo, and In Vivo Assessments

Last Advances on Hydrogel Nanoparticles Composites in Medicine: An Overview with Focus on Gold Nanoparticles

Tissue engineering modalities in skeletal muscles: focus on angiogenesis and immunomodulation properties

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