Biopolymeric nanocomposite scaffolds for bone tissue engineering applications – A review

Christy, P. Narmatha; Basha, Sakeenabi; Kumari, V. Sugantha; Bashir, A.K.H.; Mâaza, M.; Kaviyarasu, K.; Arasu, Mariadhas Valan; Al-Dhabi, Naïf Abdullah; Ignacimuthu, S.

doi:10.1016/j.jddst.2019.101452

Cited by 117 publications

(73 citation statements)

References 186 publications

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“…Gelatin (Gel) is a biocompatible, biodegradable polymer that is also used in bone tissue engineering. This biopolymer presents minimal antigenicity, is highly available, and possesses many Arg-Gly Asp sequences that promote the adherence of cells [18,19]. Moreover, it has cytokine leukemia inhibitory factor, which supports stem cell growth and proliferation [20].…”

Section: Introductionmentioning

confidence: 99%

Biomimetic Composite Scaffold Based on Naturally Derived Biomaterials

et al. 2020

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This paper proposes the development of a biomimetic composite based on naturally derived biomaterials. This freeze-dried scaffold contains a microwave-synthesized form of biomimetic hydroxyapatite (HAp), using the interwoven hierarchical structure of eggshell membrane (ESM) as bio-template. The bone regeneration capacity of the scaffold is enhanced with the help of added tricalcium phosphate from bovine Bone ash (BA). With the addition of Gelatin (Gel) and Chitosan (CS) as organic matrix, the obtained composite is characterized by the ability to stimulate the cellular response and might accelerate the bone healing process. Structural characterization of the synthesized HAp (ESM) confirms the presence of both hydroxyapatite and monetite phases, in accordance with the spectroscopy results on the ESM before and after the microwave thermal treatment (the presence of phosphate group). Morphology studies on all individual components and final scaffold, highlight their morphology and porous structure, characteristics that influence the biocompatibility of the scaffold. Porosity, swelling rate and the in vitro cytotoxicity assays performed on amniotic fluid stem cells (AFSC), demonstrate the effective biocompatibility of the obtained materials. The experimental results presented in this paper highlight an original biocomposite scaffold obtained from naturally derived materials, in a nontoxic manner.

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Section: Introductionmentioning

confidence: 99%

Biomimetic Composite Scaffold Based on Naturally Derived Biomaterials

et al. 2020

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“…Tissue engineering is an interdisciplinary field that applies the concepts of engineering and life sciences for the development of biological substitutes that maintain, restore or improve tissue or organ functions, and comprises two main strategies: scaffold-based and cell-laden approaches [ 1 , 2 , 3 , 4 , 5 , 6 ]. The scaffold-based approach, the most common strategy for bone tissue engineering applications, is based on the use of three-dimensional (3D) biocompatible and biodegradable porous structures that provide the substrate and the biomechanical environment for cells to attach, differentiate and proliferate [ 7 , 8 , 9 , 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

The Potential of Polyethylene Terephthalate Glycol as Biomaterial for Bone Tissue Engineering

et al. 2020

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The search for materials with improved mechanical and biological properties is a major challenge in tissue engineering. This paper investigates, for the first time, the use of Polyethylene Terephthalate Glycol (PETG), a glycol-modified class of Polyethylene Terephthalate (PET), as a potential material for the fabrication of bone scaffolds. PETG scaffolds with a 0/90 lay-dawn pattern and different pore sizes (300, 350 and 450 µm) were produced using a filament-based extrusion additive manufacturing system and mechanically and biologically characterized. The performance of PETG scaffolds with 300 µm of pore size was compared with polycaprolactone (PCL). Results show that PETG scaffolds present significantly higher mechanical properties than PCL scaffolds, providing a biomechanical environment that promotes high cell attachment and proliferation.

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“…Several types of biomaterial have been extensively investigated for BTE [ 33 , 34 ]; however, designing of an optimal and effective bone substitute for defects has remained challenging. An important strategy for the generation of bio-scaffolds for BTE is the potential for mimicking an osteogenic ECM [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Polymeric Gelatin Scaffolds Affect Mesenchymal Stem Cell Differentiation and Its Diverse Applications in Tissue Engineering

Wang

Hong

Wang³

et al. 2020

IJMS

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Studies using polymeric scaffolds for various biomedical applications, such as tissue engineering, implants and medical substitutes, and drug delivery systems, have attempted to identify suitable material for tissue regeneration. This study aimed to investigate the biocompatibility and effectiveness of a gelatin scaffold seeded with human adipose stem cells (hASCs), including physical characteristics, multilineage differentiation in vitro, and osteogenic potential, in a rat model of a calvarial bone defect and to optimize its design. This functionalized scaffold comprised gelatin-hASCs layers to improve their efficacy in various biomedical applications. The gelatin scaffold exhibited excellent biocompatibility in vitro after two weeks of implantation. Furthermore, the gelatin scaffold supported and specifically regulated the proliferation and osteogenic and chondrogenic differentiation of hASCs, respectively. After 12 weeks of implantation, upon treatment with the gelatin-hASCs scaffold, the calvarial bone harboring the critical defect regenerated better and displayed greater osteogenic potential without any damage to the surrounding tissues compared to the untreated bone defect. These findings suggest that the present gelatin scaffold is a good potential carrier for stem cells in various tissue engineering applications.

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Biopolymeric nanocomposite scaffolds for bone tissue engineering applications – A review

Cited by 117 publications

References 186 publications

Biomimetic Composite Scaffold Based on Naturally Derived Biomaterials

Biomimetic Composite Scaffold Based on Naturally Derived Biomaterials

The Potential of Polyethylene Terephthalate Glycol as Biomaterial for Bone Tissue Engineering

Polymeric Gelatin Scaffolds Affect Mesenchymal Stem Cell Differentiation and Its Diverse Applications in Tissue Engineering

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