Biopolymer K-carrageenan wrapped ZnO nanoparticles as drug delivery vehicles for anti MRSA therapy

Vijayakumar, Sekar; Saravanakumar, Kandasamy; Malaikozhundan, Balasubramanian; Divya, Mani; Vaseeharan, Baskaralingam; Durán-Lara, Esteban F.; Wang, Myeong‐Hyeon

doi:10.1016/j.ijbiomac.2019.12.030

Cited by 60 publications

(16 citation statements)

References 57 publications

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“…The peaks revealed at 2θ range of 31.41º, 34.14º, 35.77º, 47.22º, 56.30º, 62.66º, 67.75º, 69.01º, 72.09º, and 76.82º correspond to pure ZnO. The highest intensity peak (101) plane of zinc oxide, was observed, with other smaller intensity peaks of 100, 002, 102, 110, 103, 200, 112, 201, 004, and 202 [29]. There were no other irrelevant peaks.…”

Section: Characterization Of Samplesmentioning

confidence: 89%

Synergism of Zinc Oxide Nano-Powder with Active Compound from Turmeric and Lemongrass as Bacterial Inhibitor

Lau

Abdullah

Ghazali

et al. 2021

Walailak J Sci & Tech

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Green nanoparticles are receiving great attention due to their broad fields of application. Plant extracts are promising sources, since the synergizing process is easy and cost-effective. Green synergism offers safer nanomaterials for both human health and the environment. The antimicrobial application of prepared nanoparticles is due to special capabilities at the nanoscale size. Green zinc oxide nanoparticles (ZnONPs) from lemongrass and turmeric revealed good antibacterial properties. Antibacterial active compounds were extracted from lemongrass and turmeric using methanol as a solvent. The extracts were introduced to zinc oxide solution to create synergized green ZnONPs and tested for their antibacterial properties. The samples were characterized by means of XRD, SEM, FTIR, and GC-MS. The zones of inhibition of synergized green ZnONPs were successfully measured using the disc diffusion method. The findings using gram-negative bacteria Escherichia coli. showed a higher antibacterial inhibition zone, with a diameter of 1.6 cm. The gram-positive bacteria, Staphylococcus aureus., showed low antibacterial inhibition. The addition of ZnO had positively revealed greater inhibition. Green ZnONPs synthesized using plant extracts will be further tested for various applications. HIGHLIGHTS Green zinc oxide nanoparticles (ZnONPs) prepared from lemongrass and turmerics Plant extracts are significant in reducing and stabilizing metallic ions The synergism of ZnONPs was successfully prepared from plant extract active and evaluated for their antibacterial activity using Staphylococcus aureus and Escherichia coli The zones of inhibition of synergized green ZnONPs measured using the disc diffusion method showed a higher antibacterial inhibition zone Antibacterial activity revealed the potential applications of green synergism of ZnONPs for treatment of contaminated water, medical applications, and cosmetics GRAPHICAL ABSTRACT

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Section: Characterization Of Samplesmentioning

confidence: 89%

Synergism of Zinc Oxide Nano-Powder with Active Compound from Turmeric and Lemongrass as Bacterial Inhibitor

Lau

Abdullah

Ghazali

et al. 2021

Walailak J Sci & Tech

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“…Carrageenan has been widely used in the pharmaceutical, medical, and food industries due to its high viscosity, gelling capacity, and biocompatibility [ 63 , 64 ]. Vijayakumar et al [ 65 ] synthesized Kappa-carrageenan wrapped zinc-oxide nanoparticles (KC-ZnONPs) with antibacterial and antibiofilm activity against Methicillin-resistant S. aureus (MRSA) ( Figure 3 ). Based on hemocompatibility studies on human RBCs and eco-safety studies using Artemia salina , the synthesized KC-ZnONPs showed high biocompatibility and were non-toxic to the environment.…”

Section: Marine Bioinspired Nps Used For Bacterial Infectionmentioning

confidence: 99%

“…Silver nanoparticles, in particular, reduced prostaglandin production by inhibiting protein denaturation, cyclooxygenase, and 5-lipoxygenase. At 500 µg/mL, ZnO nanoparticles wrapped in Kappa-carrageenan demonstrated 82% antiinflammatory efficacy ( Figure 3 ) [ 65 ]. Because of their high surface area to volume ratio, these nanoparticles were more effective than bulk materials in inhibiting cytokines and inflammatory coenzymes.…”

Section: Marine Bioinspired Nps For Treating Non-infectious Diseasesmentioning

confidence: 99%

Marine-Bioinspired Nanoparticles as Potential Drugs for Multiple Biological Roles

et al. 2022

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The increased interest in nanomedicine and its applicability for a wide range of biological functions demands the search for raw materials to create nanomaterials. Recent trends have focused on the use of green chemistry to synthesize metal and metal-oxide nanoparticles. Bioactive chemicals have been found in a variety of marine organisms, including invertebrates, marine mammals, fish, algae, plankton, fungi, and bacteria. These marine-derived active chemicals have been widely used for various biological properties. Marine-derived materials, either whole extracts or pure components, are employed in the synthesis of nanoparticles due to their ease of availability, low cost of production, biocompatibility, and low cytotoxicity toward eukaryotic cells. These marine-derived nanomaterials have been employed to treat infectious diseases caused by bacteria, fungi, and viruses as well as treat non-infectious diseases, such as tumors, cancer, inflammatory responses, and diabetes, and support wound healing. Furthermore, several polymeric materials derived from the marine, such as chitosan and alginate, are exploited as nanocarriers in drug delivery. Moreover, a variety of pure bioactive compounds have been loaded onto polymeric nanocarriers and employed to treat infectious and non-infectious diseases. The current review is focused on a thorough overview of nanoparticle synthesis and its biological applications made from their entire extracts or pure chemicals derived from marine sources.

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“…The major applications in the field of biomedicine are shown as a schematic layout in Figure 6 . CGs are applied in various pharmaceutical formulations, including tablets [ 106 , 108 ], suppositories [ 109 , 110 ], films [ 111 ], fast-dissolving inserts (FDIs) [ 63 ], beads [ 112 , 113 ], pellets [ 114 , 115 , 116 ], microparticles [ 117 , 118 , 119 ], nanoparticles [ 120 , 121 , 122 , 123 , 124 , 125 ], inhalable systems, injectables [ 126 ], and hydrogels [ 127 , 128 , 129 ]. In addition, recent studies have shown that CGs are promising candidates in tissue engineering, thanks to their similarity to native glycosaminoglycans [ 127 , 128 , 130 , 131 ].…”

Section: Carrageenan In Biomedical Applicationsmentioning

confidence: 99%

“…The ecosafety assessment with Artemia salina showed that the nanoparticles were non-toxic to the environment. This study offers a “nano-anti-superbug drug” with broad-spectrum activities that may be a good candidate as a nano-antibiotic to treat MRSA infectious diseases [ 122 ].…”

Section: Carrageenan In Biomedical Applicationsmentioning

confidence: 99%

Carrageenan: Drug Delivery Systems and Other Biomedical Applications

2020

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Marine resources are today a renewable source of various compounds, such as polysaccharides, that are used in the pharmaceutical, medical, cosmetic, and food fields. In recent years, considerable attention has been focused on carrageenan-based biomaterials due to their multifunctional qualities, including biodegradability, biocompatibility, and non-toxicity, in addition to bioactive attributes, such as their antiviral, antibacterial, antihyperlipidemic, anticoagulant, antioxidant, antitumor, and immunomodulating properties. They have been applied in pharmaceutical formulations as both their bioactive and physicochemical properties make them suitable biomaterials for drug delivery, and recently for the development of tissue engineering. This article provides a review of recent research on the various types of carrageenan-based biomedical and pharmaceutical applications.

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Biopolymer K-carrageenan wrapped ZnO nanoparticles as drug delivery vehicles for anti MRSA therapy

Cited by 60 publications

References 57 publications

Synergism of Zinc Oxide Nano-Powder with Active Compound from Turmeric and Lemongrass as Bacterial Inhibitor

Synergism of Zinc Oxide Nano-Powder with Active Compound from Turmeric and Lemongrass as Bacterial Inhibitor

Marine-Bioinspired Nanoparticles as Potential Drugs for Multiple Biological Roles

Carrageenan: Drug Delivery Systems and Other Biomedical Applications

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