Biopolymer-based strategies in the design of smart medical devices and artificial organs

Altomare, Lina; Bonetti, Lorenzo; Campiglio, Chiara Emma; Nardo, Luigi De; Draghi, Lorenza; Tana, Francesca; Farè, Silvia

doi:10.1177/0391398818765323

Cited by 58 publications

(24 citation statements)

References 247 publications

(276 reference statements)

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“…It could be concluded that the intracellular uptake was increased when GNA was encapsulated in PMs and the GNA-loaded PMs with higher cytotoxicity could be also well interpreted. Previous literatures have proved that PMs have similar structures with the cell membranes, which would help PMs to pass through cell membranes and promote intracellular accumulation of drugs [35,36,37]. Besides, there were many other factors to promote the cellular uptake efficiency of PMs.…”

Section: Resultsmentioning

confidence: 99%

Amphiphilic Block Copolymer Poly (Acrylic Acid)-B-Polycaprolactone as a Novel pH-sensitive Nanocarrier for Anti-Cancer Drugs Delivery: In-vitro and In-vivo Evaluation

et al. 2019

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Gambogenic acid (GNA) has been demonstrated with outstanding antitumor activity as a potential antitumor drug in recent years. However, the low solubility and deficient bioavailability of GNA seriously hinder its practical application in the clinic area. In this study, a novel amphiphilic block copolymer, poly (acrylic acid)-b-polycaprolactone (PAA-b-PCL) is prepared and assembled into pH-responsive polymeric micelles (PMs) as one mold of drug delivery system (DDS) with unique properties. Relevant investigation on PMs exhibits excellent carrying potential and pH-dependent release performance for GNA. The drug loading capacity (DLC) and drug loading efficiency (DLE) for GNA-loaded PMs can be achieved as high as 15.20 ± 0.07% and 83.67 ± 0.49%, respectively. The in vitro experiments indicate that the GNA releasing time, cytotoxicity, and cellular uptake are significantly enhanced. Especially, the peak concentration (Cmax) and area under the curve (AUC) are promoted sharply in the GNA-loaded PMs concentration-time curve. This study not only provides a novel way to widen the application of anticancer GNA in the future, but also extends the potential of stimuli-responsive copolymers to biomedical applications.

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Section: Resultsmentioning

confidence: 99%

Amphiphilic Block Copolymer Poly (Acrylic Acid)-B-Polycaprolactone as a Novel pH-sensitive Nanocarrier for Anti-Cancer Drugs Delivery: In-vitro and In-vivo Evaluation

et al. 2019

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“…Compared to conventional thermoplastics, biopolymers exhibit poor performance in several specific properties and therefore must be modified to become more competitive [16][17][18][19] . This process resulted in different biopolymers with smart behavior and a significant change in one property upon an external trigger [20] . Biodegradable polymers are not easily classified because they can be organized according to their chemical composition, synthesis method, processing method, economic relevance, and application [21][22][23][24][25][26][27] .…”

Section: Introductionmentioning

confidence: 99%

Bionanocomposites of PLA/PBAT/organophilic clay: preparation and characterization

et al. 2019

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The objective of this study was to develop bionanocomposites from blends of poly(lactic acid) (PLA) and poly(butylene adipate-co-terephthalate) (PBAT) and from 3% and 6% bentonite clay. Initially, the bentonite clay was treated with Praepagen salt, and the properties of the modified clay were evaluated. After the organophilization of the clay was completed, 50:50 blends of PLA/PBAT were prepared, and 3 and 6% clay was added. To test the dispersion of the system, the blending sequence was performed using eight different sequences for the addition of clay to the PLA/PBAT matrices. The mixtures were prepared in a twin screw extruder, and the specimens were subsequently injection molded. The investigated mechanical and morphological properties included the yield strength, yield strain, tensile and bending elastic modulus, and scanning and transmission electron microscopy analyses. The results of this study showed increases of the mechanical properties when nanoparticles were added and the formation of bionanocomposites with intercalated structures.

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“…2,3 They include metals, 4 ceramics, 5 as well as synthetic, 6,7 and natural polymers such as collagen and some composites. [8][9][10] In recent years, tooth [11][12][13] and tooth-derived materials 14,15 have come to the fore as very promising substrates for bone regeneration because they closely resemble bone tissue, in terms of matrix composition and topography. It is of note that, unlike bone autografts/allografts, which are rarely available at need, teeth are extracted every day and customarily discarded as waste.…”

Section: Introductionmentioning

confidence: 99%

“…2,3 They include metals, 4 ceramics, 5 as well as synthetic, 6,7 and natural polymers such as collagen and some composites. 8–10…”

Section: Introductionmentioning

confidence: 99%

BMP-2 and type I collagen preservation in human deciduous teeth after demineralization

Bono

Tarsini

Candiani

2018

Journal of Applied Biomaterials & Functional Materials

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Background: Great interest has recently been focused on tooth and tooth derivatives as suitable substrates for the treatment of alveolar bone defects. Here, we propose the use of demineralized baby teeth (BT) as potential grafting materials for bone augmentation procedures. Methods: Particles of human BT (Ø < 1 mm) were demineralized by means of a chemical/thermal treatment. Demineralized BT particles were thoroughly characterized by scanning electron microscopy/energy dispersive X-ray analyses to evaluate the effects of the demineralization on BT topography and mineral phase composition, and by enzyme-linked immunosorbent assays (ELISA) to quantify collagen and bone morphogenetic protein-2 (BMP-2) protein contents. The response of SAOS-2 cells to exogenous BMP-2 stimulation was evaluated to identify the minimum BMP-2 concentration able to induce osteodifferentiation in vitro (alkaline phosphatase (ALP) activity). Results: The demineralization treatment led to a dramatic decrease in relative Ca and P content (%) of ≈75% with respect to the native BT particles, while preserving native protein conformation and activity. Interestingly, the demineralization process led to a rise in the bioavailability of BMP-2 in BT particles, as compared to the untreated counterparts. The BMP-2 content found in demineralized BT was also proved to be very effective in enhancing ALP activity, thus in the osteodifferentiation of SAOS-2 cells in vitro, as confirmed by cell experiments performed upon exogenously added BMP-2. Conclusions: In this study we demonstrate that the BMP-2 content found in demineralized BT is very effective in inducing cell osteodifferentiation, and strengthens the idea that BTs are very attractive bioactive materials for bonegrafting procedures.

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Biopolymer-based strategies in the design of smart medical devices and artificial organs

Cited by 58 publications

References 247 publications

Amphiphilic Block Copolymer Poly (Acrylic Acid)-B-Polycaprolactone as a Novel pH-sensitive Nanocarrier for Anti-Cancer Drugs Delivery: In-vitro and In-vivo Evaluation

Amphiphilic Block Copolymer Poly (Acrylic Acid)-B-Polycaprolactone as a Novel pH-sensitive Nanocarrier for Anti-Cancer Drugs Delivery: In-vitro and In-vivo Evaluation

Bionanocomposites of PLA/PBAT/organophilic clay: preparation and characterization

BMP-2 and type I collagen preservation in human deciduous teeth after demineralization

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