2010
DOI: 10.1590/s0074-02762010000700007
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Biomphalaria alexandrina snails as immunogens against Schistosoma mansoni infection in mice

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Cited by 8 publications
(3 citation statements)
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“…While, the present results illustrated significant elevation in AP activity post parasitic infection. This result is in concomitant with previous studies attributed this increment to lysosomes deflection and/or to destructive metabolism by the elevation of worm and eggs toxins since AP is considered as lysosomal enzyme and during infection all the lysosomal enzymes are enhanced due to destructive tissue initiated phagocytosis [44]. The present data also declared statistically increment in 5'-nucleotidase activity post infected mice with S. mansoni.…”
Section: Table 11supporting
confidence: 92%
“…While, the present results illustrated significant elevation in AP activity post parasitic infection. This result is in concomitant with previous studies attributed this increment to lysosomes deflection and/or to destructive metabolism by the elevation of worm and eggs toxins since AP is considered as lysosomal enzyme and during infection all the lysosomal enzymes are enhanced due to destructive tissue initiated phagocytosis [44]. The present data also declared statistically increment in 5'-nucleotidase activity post infected mice with S. mansoni.…”
Section: Table 11supporting
confidence: 92%
“…The recorded LDH increased more significantly in cancerous tissue associated with bilharzial infection than in malignant tissue. This increase in LDH was attributed to the enhancement of anaerobic glycolysis by Schistosoma toxins, suppression of pyruvate oxidative metabolism in mitochondria (where the mitochondrial enzymes were also affected) (Hamed et al 2010), marked disturbance in glycolytic pathways due to cancer complications and the overproduction and proliferation of cancer cells (Aly et al 2004).…”
Section: Resultsmentioning
confidence: 99%
“…In accordance to results herein Thangaraju et al (2009);Metwally et al (2011) reported that elevation of LDH activity in malignant and bilharzial colonic carcinoma can be used as an indicator for the stimulation of anaerobic pathways in cases of abnormal growth of human cancer cells. Aly et al (2004); Hamed et al (2010) reported that, the increase in LDH activity in bilharziasis can be related to the fact that the schistosoma parasite is producing lactate as a sole metabolic end, enhancement of anaerobic glycolysis by schistosoma toxins and suppression of pyruvate oxidative metabolism in mitochondria. Ross et al (2002) reported that the sequestered eggs in the intestinal mucosa and submucosa caused severe inflammatory reaction with cellular infiltration and consequent granuloma formation.…”
Section: Discussionmentioning
confidence: 99%