Biomonitoring of concurrent mycotoxin exposure among adults in Sweden through urinary multi-biomarker analysis

Wallin, S.; Gambacorta, Lucia; Kotova, Natalia; Lemming, Eva Warensjö; Nälsén, Cecilia; Solfrizzo, Michele; Olsen, M.

doi:10.1016/j.fct.2015.05.023

Cited by 93 publications

(61 citation statements)

References 47 publications

(44 reference statements)

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“…The detection of urinary excretion of conjugated metabolites of these mycoestrogens in over one third of the cohort without any consistent dietary sources suggests that exposure may be common, albeit producing low concentrations in urine (LOD-0.3 mg/L) and serum (LOD-0.4 nM). Two recent exposure studies from Sweden and Italy with 252 and 100 subjects, respectively, reported fractions of urine samples positive for total ZEN and a-ZEL and urine concentrations,~0.1 mg/L, similar to those in our study (Solfrizzo et al, 2014;Wallin et al, 2015). These urine concentrations can be used to place the exposures in the context of regulatory reference levels.…”

Section: Discussionsupporting

confidence: 84%

Urine and serum biomonitoring of exposure to environmental estrogens II: Soy isoflavones and zearalenone in pregnant women

Fleck

Churchwell

Doerge

et al. 2016

Food and Chemical Toxicology

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Measurable concentrations of total (parent and metabolites) GEN, DDZ and EQ were present in 240, 207 and 2 of 270 serum samples, respectively. Six out of 30 subjects had measurable concentrations of unconjugated GEN and/or DDZ in serum between 0.6 and 7.1 nM. Urine to serum total isoflavone ratios for GEN, DDZ and EQ were 13, 47, and 180, respectively. ZEN and its reductive metabolite, α-zearalenol (α-ZEL), were present in pregnant women (11 out of 30 subjects) as conjugates at levels near the limit of quantification. The average total urinary concentration was 0.10 μg/L for ZEN and 0.11 μg/L for α-ZEL.

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Section: Discussionsupporting

confidence: 84%

Urine and serum biomonitoring of exposure to environmental estrogens II: Soy isoflavones and zearalenone in pregnant women

Fleck

Churchwell

Doerge

et al. 2016

Food and Chemical Toxicology

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“…A significant incidence (above 60%) of OTA and its biomarkers in biological fluids such as milk, plasma, serum and urine was reported in most of the studies originating from Bulgaria (Petkova-Bocharova et al 2003), Czech Republic (Dohnal et al 2013;Ostry et al 2005), Italy (Biasucci et al 2011;Galvano et al 2008), Germany (Ali et al 2017;Munoz et al 2010), Hungary (Fazekas et al 2005), Portugal (Duarte et al 2010;Duarte et al 2012;Duarte et al 2009;Lino et al 2008;Pena et al 2006), Spain (Coronel et al 2011;Manique et al 2008) ,Turkey (Akdemir et al 2010;Erkekoglu et al 2010) and UK (Gilbert et al 2001). Contrary, lower incidence of the same mycotoxin was reported for Croatia (Domijan et al 2009;Sarkanj et al 2013), Norway (Skaug et al 2001), Slovakia (Dostal et al 2008) and Sweden (Wallin et al 2015).…”

Section: Mycotoxin Biomonitoring Studies In Africamentioning

confidence: 94%

Aflatoxin, fumonisin, ochratoxin, zearalenone and deoxynivalenol biomarkers in human biological fluids: A systematic literature review, 2001–2018

Al-Jaal

Jaganjac

Barcaru

et al. 2019

Food and Chemical Toxicology

136

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“…In recent years, a series of studies have focused on human exposure to DON in different countries (Brera et al, 2013;Gratz et al, 2014;Ali et al, 2015;Wallin et al, 2015). Interestingly, DON exposure in humans shows some geographical differences.…”

Section: Don Exposure Levels In Humans and Geographical Differencesmentioning

confidence: 99%

Gender and geographical variability in the exposure pattern and metabolism of deoxynivalenol in humans: a review

Chen

et al. 2016

J of Applied Toxicology

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Deoxynivalenol (DON, also known as vomitoxin) is a common mycotoxin found worldwide, especially in contaminated food. DON is toxic to a variety of cells and tissues in humans. Three kinds of conjugated products (DON-3-glucuronide, DON-15-glucuronide and DON-7-glucuronide) can be found as major metabolites in human urine. Females and males show different patterns of exposure levels, and human exposure to DON also shows some geographical differences because of different DON levels in cereal-based foods, food intake habits and UDP-glucuronosyltransferase expression. Specifically, the C12, 13-deepoxy metabolite was found predominantly in French adults but was rarely detected in UK adults. However, a cohort of Spanish individuals demonstrated even lower DON levels than the levels in the UK populations, whereas a very high DON exposure level was detected in South Africa and Linxian, China. Recent publications have further indicated that DON could be detected in the urine of pregnant women from different countries, which suggests that there is a potential risk to both mothers and foetuses. Additionally, phytochemicals have been shown to be less toxic to cells and laboratory animals in research studies and may also be used as food additives for reducing the toxic effects of DON. In this review, we provide global information on DON metabolism, human exposure and gender differences in humans. Also, control strategies for this mycotoxin are discussed. Copyright © 2016 John Wiley & Sons, Ltd.

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Biomonitoring of concurrent mycotoxin exposure among adults in Sweden through urinary multi-biomarker analysis

Cited by 93 publications

References 47 publications

Urine and serum biomonitoring of exposure to environmental estrogens II: Soy isoflavones and zearalenone in pregnant women

Urine and serum biomonitoring of exposure to environmental estrogens II: Soy isoflavones and zearalenone in pregnant women

Aflatoxin, fumonisin, ochratoxin, zearalenone and deoxynivalenol biomarkers in human biological fluids: A systematic literature review, 2001–2018

Gender and geographical variability in the exposure pattern and metabolism of deoxynivalenol in humans: a review

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