Biomineralized polymer matrix composites for bone tissue repair: a review

Zhong, Lin; Qu, Ying; Shi, Kun; Chu, Bingyang; Lei, Minyi; Huang, Keh‐Ning; Gu, Yingchun; Zhang, Qian

doi:10.1007/s11426-018-9324-0

Cited by 17 publications

(8 citation statements)

References 163 publications

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“…Bone, with its hierarchical structure and precise inorganic–organic interface, is a dynamic tissue that constantly undergoes self‐repair to maintain its load‐bearing characteristics . However, the bone remodeling process cannot adequately compensate for the destruction caused in certain cases, such as large bone fractures and defects, which require additional surgical intervention for fixing ruptured tissues and facilitating healing . Conventional technologies, including the use of metallic plates and screws, are safe and serviceable but often suffer from foreign‐body reactions, aseptic loosening, and the need to be surgically replaced or removed .…”

Section: Introductionmentioning

confidence: 99%

Bioinspired Mineral–Organic Bone Adhesives for Stable Fracture Fixation and Accelerated Bone Regeneration

Bai

Zhang

et al. 2019

Adv Funct Materials

153

147

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The use of hydrogel-based bone adhesives has the potential to revolutionize the clinical treatment of bone repairs. However, severe deficiencies remain in current products, including cytotoxicity concerns, inappropriate mechanical strength, and poor fixation performance in wet biological environments. Inspired by the unique roles of glue molecules in the robust mechanical strength and fracture resistance of bone, a design strategy is proposed using novel mineral-organic bone adhesives for strong water-resistant fixation and guided bone tissue regeneration. The system leveraged tannic acid (TA) as a phenolic glue molecule to spontaneously co-assemble with silk fibroin (SF) and hydroxyapatite (HA) in order to fabricate the inorganic-organic hybrid hydrogel (named SF@TA@HA). The combination of the strong affinity between SF and TA along with sacrificial coordination bonds between TA and HA significantly improves the toughness and adhesion strength of the hydrogel by increasing the amount of energy dissipation at the nanoscale. This in turn facilitated adequate and stable fixation of bone fracture in wet biological environments. Furthermore, SF@TA@HA promotes the regeneration of bone defects at an early stage in vivo. This work presents a type of bioinspired bone adhesive that is able to provide stable fracture fixation and accelerated bone regeneration during the bone remodeling process.

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Section: Introductionmentioning

confidence: 99%

Bioinspired Mineral–Organic Bone Adhesives for Stable Fracture Fixation and Accelerated Bone Regeneration

Bai

Zhang

et al. 2019

Adv Funct Materials

153

147

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“…Bone defects occur for many reasons, such as severe trauma, tumors, and systemic diseases ( Qiao et al, 2020 ). Most bone defects spontaneously repair, with few (5%–10%) requiring surgical treatment for recovery ( Zhong et al, 2018 ). At present, autologous bone transplantation is the preferred clinical treatment for such bone defects.…”

Section: Introductionmentioning

confidence: 99%

Drug delivery systems based on polyethylene glycol hydrogels for enhanced bone regeneration

Sun

Cui

Yuan

et al. 2023

Front. Bioeng. Biotechnol.

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Drug delivery systems composed of osteogenic substances and biological materials are of great significance in enhancing bone regeneration, and appropriate biological carriers are the cornerstone for their construction. Polyethylene glycol (PEG) is favored in bone tissue engineering due to its good biocompatibility and hydrophilicity. When combined with other substances, the physicochemical properties of PEG-based hydrogels fully meet the requirements of drug delivery carriers. Therefore, this paper reviews the application of PEG-based hydrogels in the treatment of bone defects. The advantages and disadvantages of PEG as a carrier are analyzed, and various modification methods of PEG hydrogels are summarized. On this basis, the application of PEG-based hydrogel drug delivery systems in promoting bone regeneration in recent years is summarized. Finally, the shortcomings and future developments of PEG-based hydrogel drug delivery systems are discussed. This review provides a theoretical basis and fabrication strategy for the application of PEG-based composite drug delivery systems in local bone defects.

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“…For example, bone-promoting hydroxyapatite (HA) can promote osteogenesis by promoting the adhesion of endogenous osteoblasts and bone-forming related proteins, while chitosan with antibacterial property can inhibit the colonization of pathogenic bacteria in the bone defect site by dissolving their cell membranes [ 24 , 25 ]. Functional drugs combine with carriers to construct drug delivery systems, which exert effects by contacting with related cells or pathogenic bacteria after being released to local areas [ [26] , [27] , [28] ]. The functioning of these dual function drug delivery systems also requires appropriate carrier materials including polymeric materials as well as materials of natural origin.…”

Section: Introductionmentioning

confidence: 99%

Dual-functional composite scaffolds for inhibiting infection and promoting bone regeneration

Cui

Tian

et al. 2022

Materials Today Bio

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Biomineralized polymer matrix composites for bone tissue repair: a review

Cited by 17 publications

References 163 publications

Bioinspired Mineral–Organic Bone Adhesives for Stable Fracture Fixation and Accelerated Bone Regeneration

Bioinspired Mineral–Organic Bone Adhesives for Stable Fracture Fixation and Accelerated Bone Regeneration

Drug delivery systems based on polyethylene glycol hydrogels for enhanced bone regeneration

Dual-functional composite scaffolds for inhibiting infection and promoting bone regeneration

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