Biomimetic nanochannels based biosensor for ultrasensitive and label-free detection of nucleic acids

Sun, Zhongyue; Liao, Tangbin; Zhang, Yulin; Jing, Shu; Zhang, Hong; Zhang, Guojun

doi:10.1016/j.bios.2016.06.059

Cited by 45 publications

(33 citation statements)

References 52 publications

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Section: Applicationmentioning

confidence: 99%

“…developed a DNA probe functionalized biosensor to detect DNA mismatch. [ 269 ] As shown in Figure 18c, as the complementary strands form more hydrogen bonds, more probes will be hybridized compared to the ones with a mismatch. Due to the high charge density of the back bones of the target chains, an enhanced selectivity to cation transport (ICR change) will be measured as a consequence.…”

Section: Applicationmentioning

confidence: 99%

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Track‐Etched Nanopore/Membrane: From Fundamental to Applications

2020

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Biomimetic and bio‐inspired membranes draw great attention and generate extensive efforts to solve environmental, health, and energy issues. In this field, track‐etched membranes present the advantage to be tuned from a single pore to a large‐scale multipore membrane. On one hand, from the large‐scale membrane to a single nanopore, the research becomes more fundamental, meticulous, and quantitative to describe concrete processes inside confined spaces. This allows understanding the role of the surface phenomena and nanoscale effects. On the other hand, working from a single pore to a multipore membrane allows perfect control of the membrane properties. This ensures a promising ability for upscale from the lab findings to applications. In this review, a global insight on the track‐etched nanopore/membrane is taken through presentation of fabrication and functionalization methods, transport properties, and the related applications. By functionalization, track‐etched nanopores can be used to understand ion transport under confined spaces with high aspect ratio, to analyze single molecules, to design stimuli‐responsive membranes, and to generate energy from salinity gradient and light.

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Section: Applicationmentioning

confidence: 99%

Section: Applicationmentioning

confidence: 99%

Track‐Etched Nanopore/Membrane: From Fundamental to Applications

2020

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“…Following a different functionalization approach, Sun et al developed nanofluidic channels for label‐free, ultrasensitive, and highly sequence‐specific detection of DNA . In this case, the DNA probe oligonucleotides were electrostatically adsorbed on PEI‐modified conical track‐etched PET nanochannels.…”

Section: Rational Integration Of (Bio)molecular Architectures Into Namentioning

confidence: 99%

Molecular Design of Solid‐State Nanopores: Fundamental Concepts and Applications

et al. 2019

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Solid‐state nanopores are fascinating objects that enable the development of specific and efficient chemical and biological sensors, as well as the investigation of the physicochemical principles ruling the behavior of biological channels. The great variety of biological nanopores that nature provides regulates not only the most critical processes in the human body, including neuronal communication and sensory perception, but also the most important bioenergetic process on earth: photosynthesis. This makes them an exhaustless source of inspiration toward the development of more efficient, selective, and sophisticated nanopore‐based nanofluidic devices. The key point responsible for the vibrant and exciting advance of solid nanopore research in the last decade has been the simultaneous combination of advanced fabrication nanotechnologies to tailor the size, geometry, and application of novel and creative approaches to confer the nanopore surface specific functionalities and responsiveness. Here, the state of the art is described in the following critical areas: i) theory, ii) nanofabrication techniques, iii) (bio)chemical functionalization, iv) construction of nanofluidic actuators, v) nanopore (bio)sensors, and vi) commercial aspects. The plethora of potential applications once envisioned for solid‐state nanochannels is progressively and quickly materializing into new technologies that hold promise to revolutionize the everyday life.

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“…Nanomaterials with nanopores and nanochannels have attracted much attention in relation to the significant roles of ion channels in biological cells [96,97]. To mimic biological ion channels, a polyethylene terephthalate membrane was etched in NaOH solution to create conical nanochannels with diameters of 186 ± 28 nm on the larger side and 31 ± 12 nm on the smaller side and the inner surfaces of the nanopores were coated with LbL films [98].…”

Section: Lbl Films Coated On the Surface Of Colloidal Particles And Nmentioning

confidence: 99%

Host-Guest Chemistry in Layer-by-Layer Assemblies Containing Calix[n]arenes and Cucurbit[n]urils: A Review

2018

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Biomimetic nanochannels based biosensor for ultrasensitive and label-free detection of nucleic acids

Cited by 45 publications

References 52 publications

Track‐Etched Nanopore/Membrane: From Fundamental to Applications

Track‐Etched Nanopore/Membrane: From Fundamental to Applications

Molecular Design of Solid‐State Nanopores: Fundamental Concepts and Applications

Host-Guest Chemistry in Layer-by-Layer Assemblies Containing Calix[n]arenes and Cucurbit[n]urils: A Review

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