Biomimetic electrospun nanofibers for tissue regeneration

Liao, Susan; Li, Bojun; Ma, Zuwei; He, Wei; Chan, Casey K.; Ramakrishna, Seeram

doi:10.1088/1748-6041/1/3/r01

Cited by 252 publications

(183 citation statements)

References 77 publications

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“…For example, nanofibre, a threadlike structure on a nanometre scale, has new and useful properties for filtration, as protective materials, in electrical and optical applications 7 . Nanofibre mats have also been investigated as scaffolds or physical support matrices for various types of tissue regeneration including skin, blood vessel, cartilage, bone, and nerve [8][9][10] . However, there has been no application of nanofibre mats in plant science and biotechnology.…”

Section: Introductionmentioning

confidence: 99%

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Bodhipadma¹,

Noichinda²,

Chanunpanich³

et al. 2011

ScienceAsia

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The development of new materials to be used as a substrate for plant tissue culture can lead to substantial advances in biotechnology. Here, mats consisting of a mixture of nonwoven (randomly oriented) and aligned nanofibres were produced by electrospinning solutions of polylactic acid (PLA) and polyvinylidene fluoride (PVDF). They were referred to as PLA4 and PVDF4, respectively. Callus initiation from stem explants of bilimbi (Averrhoa bilimbi L.) and aromatic chilli (Capsicum frutescens L.) occurred on these two types of nanofibre mats floated in liquid Murashige and Skoog (1962) basal medium supplemented with 2 mg/l α-naphthalene acetic acid or 2,4-dichlorophenoxy acetic acid, respectively. After subculturing for 3 weeks, the fresh weight of callus initiated from stem explants of bilimbi was significantly greater by 20% when PVDF4 rather than PLA4 nanofibre mats were used as a support matrix. In contrast, both the fresh and dry weights of callus initiated from stem explants of aromatic chilli were significantly greater by 11% and 50%, respectively, when PLA4 and not PVDF4 nanofibre mats was used. These differences in response to the two types of nanofibre mats were also found in relation to growth of callus of bilimbi and aromatic chilli during subculture. This is the first time electrospun nanofibre mats have been used in plant tissue culture research.

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Section: Introductionmentioning

confidence: 99%

Untitled

Bodhipadma¹,

Noichinda²,

Chanunpanich³

et al. 2011

ScienceAsia

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“…The scaffolds are porous and have fibers that can be tailored to affect cell differentiation, proliferation, and migration [34][35][36][37][38]. These characteristics make electrospun constructs ideal for wound dressings [39,40] and grafts for various tissues such as skin [32,[41][42][43][44][45][46], nerves [32,33,[47][48][49][50][51], vasculature [32,33,41,[51][52][53][54][55][56][57][58][59][60][61][62][63][64][65][66], muscle [33,51,67,68], bone [15,32,33,41,51,[69]…”

Section: Electrospinningmentioning

confidence: 99%

A review of electrospinning manipulation techniques to direct fiber deposition and maximize pore size

et al. 2017

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Electrospinning has been widely accepted for several decades by the tissue engineering and regenerative medicine community as a technique for nanofiber production. Owing to the inherent flexibility of the electrospinning process, a number of techniques can be easily implemented to control fiber deposition (i.e. electric/magnetic field manipulation, use of alternating current, or air-based fiber focusing) and/or porosity (i.e. air impedance, sacrificial porogen/sacrificial fiber incorporation, cryo-electrospinning, or alternative techniques). The purpose of this review is to highlight some of the recent work using these techniques to create electrospun scaffolds appropriate for mimicking the structure of the native extracellular matrix, and to enhance the applicability of advanced electrospinning techniques in the field of tissue engineering.

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“…Electrospinning is a room temperature process invented in 1934 [2] involving nano or micro fibers-based scaffolds able to be used for bone ingrowth as literature mentioned it since the late 90s [3,4]. Its biomimetic properties regarding extracellular matrix microstructure similarities enhanced cell attachment and adhesion [5][6][7]and justified this method to design fiber-based 3D scaffolds [7,8]. One-step electrospinning process is then considered as a promising technology for regenerative medicine since it is low-cost, rapid and easy to perform [9].…”

Section: Introductionmentioning

confidence: 99%

Composite Bioceramics/Polymer Electrospun Scaffolds for Regenerative Medicine

Miramond

Borget²,

Colombeix

et al. 2012

KEM

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Abstract.The main goal of this study was to succeed in the relevant association of well-known osteoconductive biphasic calcium phosphate (BCP) made of Hydroxyapatite (20% HA) and β-Tricalcium Phosphate (80% β-TCP) crystallographic phases and resorbable poly(L-lactide-co-D,Llactide)(PLDLLA) 3D matrices synthesized by electrospinning. Two types of mineral particles were obtained, BCP new hollow granules, and classical BCP particles. It appeared that hollow shells/PLDLLA composite 3D matrices allowed higher cell adhesion in vitro, thanks to internal concavities and are promising scaffolds in terms of cell carrying.

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Biomimetic electrospun nanofibers for tissue regeneration

Cited by 252 publications

References 77 publications

Untitled

Untitled

A review of electrospinning manipulation techniques to direct fiber deposition and maximize pore size

Composite Bioceramics/Polymer Electrospun Scaffolds for Regenerative Medicine

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