Biomimetic design of bone substitutes based on cuttlefish bone‐derived hydroxyapatite and biodegradable polymers

Abstract

Being a major component of bone tissue, hydroxyapatite is the most investigated calcium phosphate in the design and development of bone implants. The high brittleness and poor load-bearing properties have led researchers to manipulate hydroxyapatite performance by applying polymer or metal materials. The present study focuses on biomimetic approach of the hydroxyapatite synthesis from the cuttlefish bone in order to preserve highly porous structure. The low stiffness of hydroxyapatite scaffold was altered by thin polycaprolactone/poly(lactic acid) coating, resulting in remarkably 18-fold increase of Young's modulus. The mechanical test revealed that poly(lactic acid) increases the stiffness of composite scaffolds which depends on the polycaprolactone/poly(lactic acid) volume ratio. The composite scaffolds are bioactive supporting the deposition of new calcium phosphates when incubated in simulated physiological medium for 21 days. Moreover, the culture of human embryonic kidney cells indicated non-cytotoxicity of the composite scaffolds with emphasis on the cell proliferation during three days of culture. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2018.

Mechanical Properties of Glass Ionomer Cements after Incorporation of Marine Derived Hydroxyapatite

“…The particles in our study were obtained by hydrothermal conversion of cuttlefish bone into HA, during which its original microstructure was preserved. The HA particles formed by hydrothermal conversion have a cauliflower-like morphology, thus increasing the surface roughness and specific surface energy [21]. Moreover, it was shown that the difference in microleakage was not significantly different between the modified cements with incorporated nano-and micro-HA particles, implying that particle size cannot significantly affect the reaction [38].…”

“…Cuttlefish bones (Sepia officinalis L.) from the Adriatic Sea were used for the hydrothermal synthesis of HA, as previously described [21].…”

“…The endeavors of preparing synthetic materials with suitable structure and biocompatibility led to the use of HA from natural sources like cuttlefish bone in medical and dental applications [20]. Highly porous HA can be prepared from aragonitic cuttlefish bone by using the hydrothermal method [21].…”

Influence of doping chromium ions on the electrical properties of hydroxyapatite

“…HA, Ca10(PO4)6(OH)2, HA, is well known as biomaterial or bioceramics because of its role in substituting bone and teeth damages [1][2][3]. Although it has a significant role in bone replacement and substitution, as it forms about 60-70% of human bones [4], its application is limited due to its low brittleness [5,6]. Therefore, several efforts were carried out in order to obtain similar biomaterials which can be used in such a role with a comparably higher order of stiffness with biocompatibility and biodegradability [3,7].…”

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Hydroxyapatite Ca 10 [PO 4 ] 6 [OH] is a biocompatible widely used in medicine and dentistry. Its applications depend greatly upon lattice substitution of Calcium sites in its structure by varies cations such as Na, Mg, Sr, Ag etc.

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