Biomimetic Collagen Nanofibrous Materials for Bone Tissue Engineering

Zheng, Wenfu; Zhang, Wei; Jiang, Xingyu

doi:10.1002/adem.200980087

Cited by 59 publications

(36 citation statements)

References 175 publications

(241 reference statements)

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“…[30][31][32] The other feature is the ordered hierarchical structures that range in scale from the molecular to the macroscopic. [13,[33][34][35] Such unique hierarchical structures endow living organisms with anisotropic mechanical toughness and functionality, thereby adapting them for complicated use in external environments.…”

Section: Ordered Structures In Biological Soft Tissuesmentioning

confidence: 99%

Bioinspired Nanocomposite Hydrogels with Highly Ordered Structures

et al. 2017

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In the human body, many soft tissues with hierarchically ordered composite structures, such as cartilage, skeletal muscle, the corneas, and blood vessels, exhibit highly anisotropic mechanical strength and functionality to adapt to complex environments. In artificial soft materials, hydrogels are analogous to these biological soft tissues due to their “soft and wet” properties, their biocompatibility, and their elastic performance. However, conventional hydrogel materials with unordered homogeneous structures inevitably lack high mechanical properties and anisotropic functional performances; thus, their further application is limited. Inspired by biological soft tissues with well‐ordered structures, researchers have increasingly investigated highly ordered nanocomposite hydrogels as functional biological engineering soft materials with unique mechanical, optical, and biological properties. These hydrogels incorporate long‐range ordered nanocomposite structures within hydrogel network matrixes. Here, the critical design criteria and the state‐of‐the‐art fabrication strategies of nanocomposite hydrogels with highly ordered structures are systemically reviewed. Then, recent progress in applications in the fields of soft actuators, tissue engineering, and sensors is highlighted. The future development and prospective application of highly ordered nanocomposite hydrogels are also discussed.

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Section: Ordered Structures In Biological Soft Tissuesmentioning

confidence: 99%

Bioinspired Nanocomposite Hydrogels with Highly Ordered Structures

et al. 2017

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“…Typically, volatile organic solvents are used for electrospinning, which can alter the conformation of the dissolved collagen peptides [108] and prevent reassembly into fibrils that exhibit the native staggered configuration and distinctive banding pattern. Such malformed fibers are not stable in water and will dissolve over time [109, 112]. In addition, the toxicity and high salt content of the solvents conventionally used in electrospinning have hampered its use in cell-contacting situations.…”

Section: 0 - Isolation and Reconstitution Of Collagen Into Hydrogelmentioning

confidence: 99%

Strategies for directing the structure and function of three-dimensional collagen biomaterials across length scales

2014

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Collagen type I is a widely used natural biomaterial that has found utility in a variety of biological and medical applications. Its well characterized structure and role as an extracellular matrix protein make it a highly relevant material for controlling cell function and mimicking tissue properties. Collagen type I is abundant in a number of tissues, and can be isolated as a purified protein. This review focuses on hydrogel biomaterials made by reconstituting collagen type I from a solubilized form, with an emphasis on in vitro studies in which collagen structure can be controlled. The hierarchical structure of collagen from the nanoscale to the macroscale is described, with an emphasis on how structure is related to function across scales. Methods of reconstituting collagen into hydrogel materials are presented, including molding of macroscopic constructs, creation of microscale modules, and electrospinning of nanoscale fibers. The modification of collagen biomaterials to achieve desired structures and functions is also addressed, with particular emphasis on mechanical control of collagen structure, creation of collagen composite materials, and crosslinking of collagenous matrices. Biomaterials scientists have made remarkable progress in rationally designing collagen-based biomaterials and in applying them to both the study of biology and for therapeutic benefit. This broad review illustrates recent examples of techniques used to control collagen structure, and to thereby direct its biological and mechanical functions.

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“…The fibrillar structure of collagen is important for cell attachment, proliferation, and differentiation 3. To mimic the fibrous nature of collagen in ECM, extensive efforts have been made to fabricate ultrafine collagen fibers through various means, especially electrospinning 4–8…”

Section: Introductionmentioning

confidence: 99%

Water‐stable electrospun collagen fibers from a non‐toxic solvent and crosslinking system

Jiang

Reddy

Zhang

et al. 2012

J Biomedical Materials Res

104

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Cytocompatible and water-stable ultrafine collagen fibers were electrospun by dissolving collagen in a low corrosive ethanol-water solvent and crosslinked by citric acid (CA) with glycerol as the crosslinking extender. Conventional solvents used for electrospinning of collagen either cause denaturation or contain more than 50% salt potentially leading to poor mechanical properties and water stability of the scaffolds. Collagen scaffolds have to be modified by techniques, such as, crosslinking to overcome the limitations in strength and stability. However, the existing crosslinking methods are either cytotoxic or ineffective. In this research, a benign ethanol-water solvent system and an extender-aided CA crosslinking method were developed. The native collagen conformation was retained after electrospinning, and the dry/wet strengths and water stability of fibers were substantially enhanced after crosslinking. The crosslinked electrospun scaffolds could maintain their fibrous structure for up to 30 days in phosphate-buffered saline at 37°C. Cells exhibited better attachment and growth on the CA crosslinked collagen fibers than on the glutaraldehyde crosslinked scaffolds.

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Biomimetic Collagen Nanofibrous Materials for Bone Tissue Engineering

Cited by 59 publications

References 175 publications

Bioinspired Nanocomposite Hydrogels with Highly Ordered Structures

Bioinspired Nanocomposite Hydrogels with Highly Ordered Structures

Strategies for directing the structure and function of three-dimensional collagen biomaterials across length scales

Water‐stable electrospun collagen fibers from a non‐toxic solvent and crosslinking system

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