Biomimetic catalytic activity and structural diversity of cobalt complexes with N3O-donor Schiff base ligand

Ligand directed synthesis of a unprecedented tetragonalbipyramidal copper (II) complex and its antibacterial activity and catalytic role in oxidative dimerisation of 2‐aminophenol

“…Switching of the electronic band from 400 nm to 407 nm is a definite signature for the oxidation of 2‐AP in MeCN. [ 13,15,44 ] This spectrophotometric evidence may correspond to the development of aminophenoxazinone species in solution.…”

“…Absorbance vs. wavelength (wavelength scans) of the solution was monitored through spectrophometer at a regular time interval of 6 min for 1 hr in the wavelength range from 300–700 nm. [ 13,15 ]…”

“…Kinetic experiments were also carried out spectrophotometrically to specify the efficacy of catalytic oxidation of aminophenol by the Cu (II) complex in MeCN at 298 K. [ 13,15 ] 0.04 ml of the complex solution with a constant concentration of 1 × 10 −4 M was added to 2 ml solution of 2‐AP of a particular concentration (varying its concentration from 1 × 10 −3 M to 1 × 10 −2 M) to achieve the ultimate concentration as 1 × 10 −4 M. The conversion of 2‐aminophenol to 2‐aminophenoxazine‐3‐one was monitored with time at a wavelength 407 nm (time scan) in MeCN. [ 13,15,37,38 ] To determine the dependence of rate on substrate concentration, kinetic analyses were performed in triplicate.…”

“…[ 8–11 ] It pursuit of deep understanding of different biological oxidation processes in nature, synthetic coordination chemists have been stepped forward to tune electronic and geometric factors of the ligands in engineering bio‐inspired coordination driven compounds. [ 12–15 ] It is well documented that the bio‐inspired synthetic analogues also serve as magic catalysts in several catalytic oxidation reactions of laboratory and industrial significance. [ 14–16 ] Among the different oxidase enzymes, phenoxazinone synthase has drawn special attention [ 14,15 ] as the oxidized product, aminophenoxazinone acts as an antineoplastic agent named actinomycin D (questiomycin A) which is usually recommended in the treatment of certain types of cancer.…”

“…[ 12–15 ] It is well documented that the bio‐inspired synthetic analogues also serve as magic catalysts in several catalytic oxidation reactions of laboratory and industrial significance. [ 14–16 ] Among the different oxidase enzymes, phenoxazinone synthase has drawn special attention [ 14,15 ] as the oxidized product, aminophenoxazinone acts as an antineoplastic agent named actinomycin D (questiomycin A) which is usually recommended in the treatment of certain types of cancer. [ 17–20 ] Furthermore, 2‐aminophenoxazin‐3‐one and 3‐aminophenoxazin‐2‐one compounds show potential antimicrobial, antiviral, and antitumor activities against different pathogens.…”