Biomimetic cartilage-lubricating polymers regenerate cartilage in rats with early osteoarthritis

Xie, Renjian; Hui-yuan, Yao; Mao, Angelina S.; Zhu, Ye; Qi, Dawei; Jia, Yong‐Guang; Gao, Meng; Chen, Yunhua; Wang, Lin; Wang, Dong‐An; Wang, Kun; Liu, Sa; Ren, Li; Mao, Chuanbin

doi:10.1038/s41551-021-00785-y

Cited by 101 publications

(103 citation statements)

References 53 publications

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“…Indeed, rationally designed lubricating polymers can enhance cartilage regeneration in rats with early osteoarthritis. [ 21 ] Whereas transformable nanoparticles have been developed as triggerable nanotherapies or nanovaccines for cancer therapy most recently, [ 22 ] our studies, for the first time, demonstrated that rationally engineered hydrogel‐transforming nanoparticles can be used for tissue protection and drug delivery for the treatment of diverse inflammatory diseases.…”

Section: Resultsmentioning

confidence: 99%

Hydrogel Transformed from Nanoparticles for Prevention of Tissue Injury and Treatment of Inflammatory Diseases

et al. 2022

Advanced Materials

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Hydrogels can be formed via physical entanglement, noncovalent interactions, and chemical cross-linking. By rational design at the molecular level, enhanced physicochemical properties, such as shear thinning, self-healing, and responsive capacities may be afforded to hydrogels. Of note, considerable efforts have been devoted to engineering stimuli-responsive hydrogels, [2] since their formation, degradation, multiscale shape, architecture, and functions can be easily and precisely manipulated via different physical, chemical, and biological signals in spatiotemporally controlled and/or programmed manners. In this aspect, different exogenous and endogenous bio-physicochemical triggers are generally utilized to precisely control hydrogel formation/ degradation, finely tune the mechanics of hydrogels, and dynamically modulate hydrogel microenvironment. [2d,3] Hydrogels responsive to temperature, light, electrical/magnetic fields, ultrasound, mechanical forces, pH, redox potentials, and biochemical agents have been extensively examined for on-demand therapeutic delivery of drugs and cells to treat different acute and chronic diseases, [3a,4] for which controlled release of molecular and cellular payloads is mainly achieved by triggering transitions between hydrogel and solution phases or hydrogels and solid states. Also, stimuli-responsive hydrogels have been Functional hydrogels responsive to physiological and pathological signals have extensive biomedical applications owing to their multiple advanced attributes. Herein, engineering of functional hydrogels is reported via transformable nanoparticles in response to the physiologically and pathologically acidic microenvironment. These nanoparticles are assembled by a multivalent hydrophobic, pH-responsive cyclodextrin host material and a multivalent hydrophilic guest macromolecule. Driven by protons, the pH-responsive host-guest nanoparticles can be transformed into hydrogel, resulting from proton-triggered hydrolysis of the host material, generation of a hydrophilic multivalent host compound, and simultaneously enhanced inclusion interactions between host and guest molecules. By in situ forming a hydrogel barrier, the orally delivered transformable nanoparticles protect mice from ethanol-or drug-induced gastric injury. In addition, this type of nanoparticles can serve as responsive and transformable nanovehicles for therapeutic agents to achieve triggerable and sustained drug delivery, thereby effectively treating typical inflammatory diseases, including periodontitis and arthritis in rats. With combined advantages of nanoparticles and hydrogels, together with their good in vivo safety, the engineered transformable nanoparticles hold great promise in tissue injury protection and site-specific/local delivery of molecular and cellular therapeutic agents.

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Section: Resultsmentioning

confidence: 99%

Hydrogel Transformed from Nanoparticles for Prevention of Tissue Injury and Treatment of Inflammatory Diseases

et al. 2022

Advanced Materials

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“…Articular cartilage damage and degeneration caused by injury, disease, and population aging are very common clinically, and there is a great clinical need for the regeneration and repair of articular cartilage [ [31] , [32] , [33] ]. Despite the great achievements of tissue engineering technology for cartilage repair [ [34] , [35] , [36] , [37] ], it has not become the mainstream technology of articular cartilage repair thus far.…”

Section: Discussionmentioning

confidence: 99%

Acellular cartilage matrix biomimetic scaffold with immediate enrichment of autologous bone marrow mononuclear cells to repair articular cartilage defects

Jia

Zhang

et al. 2022

Materials Today Bio

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“…Hydrogels based on 2-methacryloyloxyethyl phosphorylcholine (PMPC) ( Milner et al, 2018 ), chitosan (CS) ( Talaat et al, 2020 ), gellan gum (GG) ( Leone et al, 2020 ), and other materials have been proposed as biomimetic lubricants to reduce cartilage damage. Xie et al proposed a method to simulate brush-lubricated composite nanofibers ( Xie et al, 2021 ). Two types of brush nanofibers, one of which is HA/PA, are formed by covalently grafting a high hydrophilic lubricant brush polymer poly-2-acrylamide-2-methylpropanesulfonic acid sodium salt (PAMPS) as a side chain onto the hyaluronic acid (HA) backbone ( Figure 3 ).…”

Section: Treatment Strategy Of Hydrogel In Early Stage Of Osteoarthritismentioning

confidence: 99%

Hydrogels for Treatment of Different Degrees of Osteoarthritis

Wang

Qiu

Liu

et al. 2022

Front. Bioeng. Biotechnol.

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Osteoarthritis (OA) is a common disease that severely restricts human activities and degrades the quality of life. Every year, millions of people worldwide are diagnosed with osteoarthritis, placing a heavy burden on society. Hydrogels, a polymeric material with good biocompatibility and biodegradability, are a novel approach for the treatment of osteoarthritis. In recent years, this approach has been widely studied with the development of materials science and tissue engineering technology. We reviewed the research progress of hydrogels in the treatment of osteoarthritis in the past 3 years. We summarized the required hydrogel properties and current applications according to the development and treatment of osteoarthritis. Furthermore, we listed the challenges of hydrogels for different types of osteoarthritis and presented prospects for future development.

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Biomimetic cartilage-lubricating polymers regenerate cartilage in rats with early osteoarthritis

Cited by 101 publications

References 53 publications

Hydrogel Transformed from Nanoparticles for Prevention of Tissue Injury and Treatment of Inflammatory Diseases

Hydrogel Transformed from Nanoparticles for Prevention of Tissue Injury and Treatment of Inflammatory Diseases

Acellular cartilage matrix biomimetic scaffold with immediate enrichment of autologous bone marrow mononuclear cells to repair articular cartilage defects

Hydrogels for Treatment of Different Degrees of Osteoarthritis

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