Hydrogels for Treatment of Different Degrees of Osteoarthritis

Wang, Shuze; Qiu, Yueyang; Liu, Qu; Wang, Qiang; Zhou, Qing

doi:10.3389/fbioe.2022.858656

Cited by 18 publications

(21 citation statements)

References 121 publications

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“…Interestingly, through the amplitude and frequency sweep study, we have revealed that the fabricated hydrogel can also resist the deformation caused by mechanical stress, which is very crucial as, during the RA, circumventing joint pain is necessary. When injected into the joint cavity, this hydrogel swells after absorbing the body fluid and forms a cushion-like scaffold, which minimizes the bone-to-bone contact [ 51 , 52 ]. Furthermore, through several in vitro studies, we have also verified the biodegradability and biocompatibility of the fabricated hydrogels.…”

Section: Discussionmentioning

confidence: 99%

ECM-mimetic, NSAIDs loaded thermo-responsive, immunomodulatory hydrogel for rheumatoid arthritis treatment

Shah,

Ghosh,

et al. 2024

BMC Biotechnol

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Background Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease, and it leads to irreversible inflammation in intra-articular joints. Current treatment approaches for RA include non-steroidal anti-inflammatory drugs (NSAIDs), disease-modifying anti-rheumatic drugs (DMARDs), corticosteroids, and biological agents. To overcome the drug-associated toxicity of conventional therapy and transdermal tissue barrier, an injectable NSAID-loaded hydrogel system was developed and explored its efficacy. Results The surface morphology and porosity of the hydrogels indicate that they mimic the natural ECM, which is greatly beneficial for tissue healing. Further, NSAIDs, i.e., diclofenac sodium, were loaded into the hydrogel, and the in vitro drug release pattern was found to be burst release for 24 h and subsequently sustainable release of 50% drug up to 10 days. The DPPH assay revealed that the hydrogels have good radical scavenging activity. The biocompatibility study carried out by MTT assay proved good biocompatibility and anti-inflammatory activity of the hydrogels was carried out by gene expression study in RAW 264.7 cells, which indicate the downregulation of several key inflammatory genes such as COX-2, TNF-α & 18s. Conclusion In summary, the proposed ECM-mimetic, thermo-sensitive in situ hydrogels may be utilized for intra-articular inflammation modulation and can be beneficial by reducing the frequency of medication and providing optimum lubrication at intra-articular joints. Graphical Abstract

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Section: Discussionmentioning

confidence: 99%

ECM-mimetic, NSAIDs loaded thermo-responsive, immunomodulatory hydrogel for rheumatoid arthritis treatment

Shah,

Ghosh,

et al. 2024

BMC Biotechnol

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“…Osteoarthritis (OA) is a typical complex and multifactorial joint disease that requires combination therapy as it involves a cascade of pathological processes, beginning with damage to the articular cartilage and leading to a disruption of lubrication. − Clinically, over 60% of individuals with OA are in the advanced stage, where chronic joint inflammation, dysfunction in lubrication, and degradation of cartilage tissue are recognized as the three crucial aspects that worsen the condition. , The increasing evidence suggests that a combination of multiple drugs may present a promising strategy for more effective treatment of OA. − However, existing treatments primarily concentrate on only partial OA key factors, effectively alleviating the symptoms but failing to recover advanced OA . Addressing the three crucial factors simultaneously and achieving sustained effectiveness are essential to halting the progression of advanced OA, but the rational design of these systems is highly complicated and challenging.…”

Section: Introductionmentioning

confidence: 99%

Supramolecular 3 in 1: A Lubrication and Co-Delivery System for Synergistic Advanced Osteoarthritis Therapy

Chen,

Li,

Zhu

et al. 2024

ACS Nano

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The complexity, heterogeneity, and drug resistance of diseases necessitate a shift in therapeutic paradigms from monotherapy to combination therapy, which could augment treatment efficiency. Effective treatment of advanced osteoarthritis (OA) requires addressing three key factors contributing to its deterioration: chronic joint inflammation, lubrication dysfunction, and cartilagetissue degradation. Herein, we present a supramolecular nanomedicine of multifunctionality via molecular recognition and selfassembly. The employed macrocyclic carrier, zwitterion-modified cavitand (CV-2), not only accurately loads various drugs but also functions as a therapeutic agent with lubricating properties for the treatment of OA. Kartogenin (KGN), a drug for articular cartilage regeneration and protection, and flurbiprofen (FP), an antiinflammatory agent, were coloaded onto CV-2 assembly, forming a supramolecular nanomedicine KGN&FP@CV-2. The three-in-one combination therapy of KGN&FP@CV-2 addresses the three pathological features for treating OA collectively, and thus provides long-term therapeutic benefits for OA through sustained drug release and intrinsic lubrication in vivo. The multifunctional integration of macrocyclic delivery and therapeutics provides a simple, flexible, and universal platform for the synergistic treatment of diseases involving multiple drugs.

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“…These approaches provide a new avenue for research in cartilage regeneration [ 15 ]. There are two frontline trends of hydrogel-based therapies for OA therapy [ 15 , 16 ]. The first one is using a hydrogel-based tissue scaffold implants for cartilage tissue regeneration, which falls within the scope of tissue engineering [ 17 – 19 ].…”

Section: Introductionmentioning

confidence: 99%

Adhesive hydrogels in osteoarthritis: from design to application

et al. 2023

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Osteoarthritis (OA) is the most common type of degenerative joint disease which affects 7% of the global population and more than 500 million people worldwide. One research frontier is the development of hydrogels for OA treatment, which operate either as functional scaffolds of tissue engineering or as delivery vehicles of functional additives. Both approaches address the big challenge: establishing stable integration of such delivery systems or implants. Adhesive hydrogels provide possible solutions to this challenge. However, few studies have described the current advances in using adhesive hydrogel for OA treatment. This review summarizes the commonly used hydrogels with their adhesion mechanisms and components. Additionally, recognizing that OA is a complex disease involving different biological mechanisms, the bioactive therapeutic strategies are also presented. By presenting the adhesive hydrogels in an interdisciplinary way, including both the fields of chemistry and biology, this review will attempt to provide a comprehensive insight for designing novel bioadhesive systems for OA therapy.

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Hydrogels for Treatment of Different Degrees of Osteoarthritis

Cited by 18 publications

References 121 publications

ECM-mimetic, NSAIDs loaded thermo-responsive, immunomodulatory hydrogel for rheumatoid arthritis treatment

ECM-mimetic, NSAIDs loaded thermo-responsive, immunomodulatory hydrogel for rheumatoid arthritis treatment

Supramolecular 3 in 1: A Lubrication and Co-Delivery System for Synergistic Advanced Osteoarthritis Therapy

Adhesive hydrogels in osteoarthritis: from design to application

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