Supramolecular 3 in 1: A Lubrication and Co-Delivery System for Synergistic Advanced Osteoarthritis Therapy
Meng-Meng Chen,
Yuqiao Li,
Yujie Zhu
et al.
Abstract:The complexity, heterogeneity, and drug resistance of diseases necessitate a shift in therapeutic paradigms from monotherapy to combination therapy, which could augment treatment efficiency. Effective treatment of advanced osteoarthritis (OA) requires addressing three key factors contributing to its deterioration: chronic joint inflammation, lubrication dysfunction, and cartilagetissue degradation. Herein, we present a supramolecular nanomedicine of multifunctionality via molecular recognition and selfassembly… Show more
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