Biomedical applications of polysaccharide nanoparticles for chronic inflammatory disorders: Focus on rheumatoid arthritis, diabetes and organ fibrosis

Abstract

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Polysaccharide-Based Transdermal Drug Delivery

“…Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects the joints. Polysaccharides and polysaccharides-based nanoparticles have been widely researched in RA treatment [ 194 ]. Dendrobium huoshanense stem polysaccharide treats RA by inhibiting inflammatory signaling pathways [ 195 ].…”

The Therapeutic Potential of Targeted Nanoparticulate Systems to Treat Rheumatoid Arthritis

“…Peptides and polysaccharides may be degraded in the body using enzymes and the breakdown rate can be controlled to get the desired release profile. Dextran, gelatin, poly(L-lysine), chitosan, and alginate are among them [21,54]. The delivery channels and disease targets may all benefit from synthetic polymers that have desired features such as hydrophobicity and degradation profile.…”

Natural Polysaccharide-Based Nanodrug Delivery Systems for Treatment of Diabetes

“…Polysaccharides are natural biopolymers that play different roles in microorganisms, plants and animals [ 12 ]. They consist of long monomers of similar type or combinations of other monomer chains [ 13 ]. Natural polysaccharides are recognized as safe for targeting delivery due to their superior characteristics, including non-toxicity and non-reactivity, easy availability on a large scale, relative cheapness, significant biocompatibility and extraordinary biodegradability ( Figure 1 ) [ 14 , 15 ].…”