Natural Polysaccharide-Based Nanodrug Delivery Systems for Treatment of Diabetes

Qiu, Aijun; Wang, Yunyun; Zhang, Genlin; Wang, He-Bin

doi:10.3390/polym14153217

Cited by 42 publications

(29 citation statements)

References 152 publications

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“…In recent years, natural polysaccharides have been considered as the ideal candidates for novel drug delivery systems due to their good biocompatibility, biodegradation, low immunogenicity, renewable source and easy modification [ 29 ]. These natural polymers are widely used in designing nanocarriers, which find a wide application in therapeutics, diagnostics, delivery and protection of bioactive compounds or drugs.…”

Section: Bc-based Nanocompositesmentioning

confidence: 99%

“…These natural polymers are widely used in designing nanocarriers, which find a wide application in therapeutics, diagnostics, delivery and protection of bioactive compounds or drugs. Recently, interesting reviews were published in the Journal ‘Polymers’ characterizing the composite materials used in drug delivery systems [ 5 , 29 , 30 ]. The review by Qiu et al introduced a series of polysaccharide-based nanodrug delivery systems such as nanoparticles, nanoliposomes, nanomicelles, nanoemulsions and nanohydrogels for diabetes treatment [ 29 ].…”

Section: Bc-based Nanocompositesmentioning

confidence: 99%

“…Recently, interesting reviews were published in the Journal ‘Polymers’ characterizing the composite materials used in drug delivery systems [ 5 , 29 , 30 ]. The review by Qiu et al introduced a series of polysaccharide-based nanodrug delivery systems such as nanoparticles, nanoliposomes, nanomicelles, nanoemulsions and nanohydrogels for diabetes treatment [ 29 ]. The review Huo et al represented the typical drug release behaviors and the drug release mechanisms of nanocellulose-based composite materials, and considered the potential application of these composites [ 30 ].…”

Section: Bc-based Nanocompositesmentioning

confidence: 99%

“…Due to its unique properties, BC is a promising material for industry and technology [ 18 ]. It has great potential to be used in medicine [ 4 , 19 , 20 , 21 , 22 ] as a biomaterial for tissue engineering [ 20 , 23 , 24 ], wound dressing [ 25 , 26 , 27 , 28 ] and drug delivery systems [ 5 , 29 , 30 , 31 , 32 ], it can be applied in electronics (sensors, energy storage devices, speakers, acoustic membranes) [ 33 ], the environmental industry (water purification, filtration and adsorption techniques) [ 34 , 35 ], and the food industry (artificial food, additives, food packaging [ 36 ]. The relatively large diversity of cellulose-producing microorganisms, as well as a wide variety of cultivation methods, creates an excellent opportunity to modify and adjust the properties of the material and find new areas of its application.…”

Section: Introductionmentioning

confidence: 99%

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Bacterial Cellulose-Based Polymer Nanocomposites: A Review

et al. 2022

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Bacterial cellulose (BC) is currently one of the most popular environmentally friendly materials with unique structural and physicochemical properties for obtaining various functional materials for a wide range of applications. In this regard, the literature reporting on bacterial nanocellulose has increased exponentially in the past decade. Currently, extensive investigations aim at promoting the manufacturing of BC-based nanocomposites with other components such as nanoparticles, polymers, and biomolecules, and that will enable to develop of a wide range of materials with advanced and novel functionalities. However, the commercial production of such materials is limited by the high cost and low yield of BC, and the lack of highly efficient industrial production technologies as well. Therefore, the present review aimed at studying the current literature data in the field of highly efficient BC production for the purpose of its further usage to obtain polymer nanocomposites. The review highlights the progress in synthesizing BC-based nanocomposites and their applications in biomedical fields, such as wound healing, drug delivery, tissue engineering. Bacterial nanocellulose-based biosensors and adsorbents were introduced herein.

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Section: Bc-based Nanocompositesmentioning

confidence: 99%

Section: Bc-based Nanocompositesmentioning

confidence: 99%

Section: Bc-based Nanocompositesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bacterial Cellulose-Based Polymer Nanocomposites: A Review

et al. 2022

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“…In the food industry, BG is typically used to prepare soups, sauces, beverages, and other food products where it serves as an emulsifier, stabilizing agent, and thickening agent [ 1 ]. The hydrophilic property, high absorption capacity, and biocompatibility of BG make it potentially useful in a variety of fields, including skin care [ 2 ], drug delivery [ 3 ], and wound healing [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Mushroom β-Glucan Recovered from Antler-Type Fruiting Body of Ganoderma lucidum by Enzymatic Process and Its Potential Biological Activities for Cosmeceutical Applications

et al. 2022

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Mushrooms are incredibly valuable macro fungi that are an important and integral part of the ecosystem. In addition to being used as cuisine, mushrooms have been used for medicinal purposes for many centuries. This research applied a process for recovering β-glucan (BG) from the antler-type fruiting body of Ganoderma lucidum as well as tested the biological activities related to cosmeceutical applications. The characterization of complex structure was performed by fourier-transform infrared (FTIR) and nuclear magnetic resonance (MNR) spectroscopies. The obtained extract contained 40.57% BG and 7.47% protein, with the detectable bioactivities of anti-tyrosinase and antioxidation. Consequently, it showed the activity that can be used to whiten the skin by reducing or inhibiting the process of skin pigmentation. The BG also showed moderate activities of anti-collagenase, anti-elastase, and anti-hyaluronidase. The test by the HET-CAM confirmed no skin irritation of the complex extract. Based on human peripheral blood mononuclear cell (PBMC) test, the BG had no significant inhibiting effect on cell viability. In addition, the obtained BG had functional properties higher than commercially available BG, especially oil-binding capacity. These findings provided new insights into the potential application of G. lucidum BG as a polymeric material in the cosmeceutical industries.

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