Polysaccharide-Based Transdermal Drug Delivery

Abstract

Materials derived from natural plants and animals have great potential for transdermal drug delivery. Polysaccharides are widely derived from marine, herbal, and microbial sources. Compared with synthetic polymers, polysaccharides have the advantages of non-toxicity and biodegradability, ease of modification, biocompatibility, targeting, and antibacterial properties. Currently, polysaccharide-based transdermal drug delivery vehicles, such as hydrogel, film, microneedle (MN), and tissue scaffolds are being developed. The addition of polysaccharides allows these vehicles to exhibit better-swelling properties, mechanical strength, tensile strength, etc. Due to the stratum corneum’s resistance, the transdermal drug delivery system cannot deliver drugs as efficiently as desired. The charge and hydration of polysaccharides allow them to react with the skin and promote drug penetration. In addition, polysaccharide-based nanotechnology enhances drug utilization efficiency. Various diseases are currently treated by polysaccharide-based transdermal drug delivery devices and exhibit promising futures. The most current knowledge on these excellent materials will be thoroughly discussed by reviewing polysaccharide-based transdermal drug delivery strategies.

Natural Polysaccharide-Based Nanodrug Delivery Systems for Treatment of Diabetes

“…HA can function as a lubricant and shock absorber, therefore it is approved by the FDA as an injectable to treat knee pain in osteoarthritis or for facial implants to make skin appear smoother. It is necessary for embryonic development, wound healing repair, and inflammation [ 56 , 57 ]. HA has attracted significant interest in development of drug delivery systems because of its intrinsic physicochemical and biological properties [ 58 ].…”

Recent Reports on Polysaccharide-Based Materials for Drug Delivery

“…The composite ALG-based materials are often used for transdermal drug delivery, such as microneedles, films, scaffolds, or hydrogels [ 46 ]. The latter are often studied for their use as wound dressings.…”

Recent Advancements in Microneedle Technology for Multifaceted Biomedical Applications

“…The solid MNs were used to transfer the drug through micronized channels formed inside the skin layer and improved drug diffusion [ 15 , 16 ]. In solid MNs, the drug is bound to the channel, and the microchannel is closed to prevent the entry of toxic materials by using termination therapy [ 17 , 18 , 19 ].…”

“…These non-invasive MNs comprise steel for siRNA [ 41 ]. Important parameters that need to be optimized in these MNs preparations are the homogenous coating, stability, the method used for MN coating (spraying or dip coating) and release from the MN [ 15 ]. Gill and Prausnitz et al showed a reduction in the surface area and a high viscosity could improve the efficiency of these MNs for drug delivery [ 42 ].…”