Biomechanical Properties: Effects of Low-level Laser Therapy and Biosilicate<sup>®</sup> on Tibial Bone Defects in Osteopenic Rats

Fangel, Renan; Bossini, Paulo Sérgio; Rennó, Ana Cláudia Muniz; Granito, Renata Neves; Wang, Charles C; Nonaka, Keico Okino; Driusso, Patrícia; Parizotto, Nivaldo Antônio; Oishi, Jorge

doi:10.5301/jabfm.5000198

Cited by 9 publications

(20 citation statements)

References 31 publications

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“…The results presented by our study corroborate the results of Iatecola et al [17], who used autogenous bone graft (ABG) associated with HFB and PBMT. PBMT also showed satisfactory results in helping to reconstruct long bones when associated with biomaterials such as synthetic hydroxyapatite [41], biosilicate ® [31], and Celecoxib ® [69], in addition to an increase bone mineral density with salmon calcitonin [70].…”

Section: Discussionmentioning

confidence: 97%

“…We observed tissue biocompatibility of these scaffolds, in addition to greater maturation of bone tissue in the final period of the experiment. PBMT has shown positive effects on different types of tissue recovery [13,16,31,41], but there are still controversies regarding the appropriate parameters to be used.…”

Section: Discussionmentioning

confidence: 99%

“…The choice of long bones such as the tibia for bone repair is related to its ease of manipulation and access and its similarity to the clinical application in humans, regarding remodeling, repair in the physiology of muscle strength and tension. When dealing with critical defects, larger animals should be used, such as sheep and pigs [31,33,34,36,42]. In addition, biomaterials are used in orthopedic medical surgeries performed to correct bone defects of dimensions that do not spontaneously repair, as well as in patients with osteoporosis or cancer [42,43].…”

Section: Discussionmentioning

confidence: 99%

“…15 scalpel blade, a 20 mm long linear incision was made in the craniocaudal direction, sectioning the skin and muscle fasciae, reaching the periosteum and extending it for tibial exposure. With an AR 6 steel carbide drill (Beavers Dental ® , Morrisburg, ON, Canada, K0C 1 × 0/Ormex SA) coupled to a 1500 rpm low-speed micromotor, a 2 mm diameter cavity was prepared [31][32][33][34][35] in a depth reaching the bone marrow without damaging the contralateral cortical [18,[36][37][38][39], with abundant irrigation of 0.9% sodium chloride solution.…”

Section: Monocortical Defect Surgerymentioning

confidence: 99%

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Photobiomodulation Therapy Associated with Heterologous Fibrin Biopolymer and Bovine Bone Matrix Helps to Reconstruct Long Bones

et al. 2020

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Bone defects cause aesthetic and functional changes that affect the social, economic and especially the emotional life of human beings. This complication stimulates the scientific community to investigate strategies aimed at improving bone reconstruction processes using complementary therapies. Photobiomodulation therapy (PBMT) and the use of new biomaterials, including heterologous fibrin biopolymer (HFB), are included in this challenge. The objective of the present study was to evaluate the influence of photobiomodulation therapy on bone tibial reconstruction of rats with biomaterial consisting of lyophilized bovine bone matrix (BM) associated or not with heterologous fibrin biopolymer. Thirty male rats were randomly separated into three groups of 10 animals. In all animals, after the anesthetic procedure, a noncritical tibial defect of 2 mm was performed. The groups received the following treatments: Group 1: BM + PBMT, Group 2: BM + HFB and Group 3: BM + HFB + PBMT. The animals from Groups 1 and 3 were submitted to PBMT in the immediate postoperative period and every 48 h until the day of euthanasia that occurred at 14 and 42 days. Analyses by computed microtomography (µCT) and histomorphometry showed statistical difference in the percentage of bone formation between Groups 3 (BM + HB + PBMT) and 2 (BM + HFB) (26.4% ± 1.03% and 20.0% ± 1.87%, respectively) at 14 days and at 42 days (38.2% ± 1.59% and 31.6% ± 1.33%, respectively), and at 42 days there was presence of bone with mature characteristics and organized connective tissue. The µCT demonstrated BM particles filling the defect and the deposition of new bone in the superficial region, especially in the ruptured cortical. It was concluded that the association of PBMT with HFB and BM has the potential to assist in the process of reconstructing bone defects in the tibia of rats.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Monocortical Defect Surgerymentioning

confidence: 99%

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Photobiomodulation Therapy Associated with Heterologous Fibrin Biopolymer and Bovine Bone Matrix Helps to Reconstruct Long Bones

et al. 2020

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“…Some authors recommend that laser BS should be applied at high parameters in order to affect hard tissue healing. 34,35 However, some other authors advocate the exact opposite. 36,37 The energy density is the most important parameter in laser BS.…”

Section: Discussionmentioning

confidence: 99%

Short term histopathological effects of GaAlAs laser on experimentally induced TMJ osteoarthritis in rabbits

2018

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The aim of this study was to evaluate the biostimulation (BS) effect of the gallium-aluminum-arsenide (GaAlAs) diode laser by histopathology with an experimental osteoarthritis (OA) model in the temporomandibular joints (TMJ) of rabbits, in the early period. GaAlAs diode laser is used for pain reduction in TMJ disorders. Twenty-four adult male New Zealand white rabbits were randomly divided into three equal groups: Control Group (CG), Study Group 1 (SG-1), and Study Group 2 (SG-2). Mono-iodoacetate (MIA) was administered to the right TMJs of all rabbits. The rabbits did not undergo any treatment for four weeks to allow the development of osteoarthritis. In SG-1, laser BS was applied to the rabbits at 940 nm, 5 W, and 15 J/cm2 in continuous wave mode at 48-hour intervals for 14 sessions; and in SG-2, laser BS was applied with the same parameters at 24-hour intervals for 28 sessions. Laser BS was not applied to the rabbits in CG. All rabbits were sacrificed simultaneously. The TMJ cartilage, osteochondral junction, chondrocyte appearance, and subchondral ossification were evaluated histopathologically. There was no statistically significant difference between the groups in terms of cartilage, osteochondral junction, chondrocyte appearance, and subchondral ossification values (p > 0.05). The laser BS protocol used in the study had no positive histopathological effects on TMJ OA in the early period.

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Effects of photobiomodulation on bone defects grafted with bone substitutes: A systematic review of in vivo animal studies

Hanna

Dalvi

Amaroli

et al. 2020

Journal of Biophotonics

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A present, photobiomodulation therapy (PBMT) effectiveness in enhancing bone regeneration in bone defects grafted with or without biomaterials is unclear. This systematic review (PROSPERO, ref. CRD 42019148959) aimed to critically appraise animal in vivo published data and present the efficacy of PBMT and its potential synergistic effects on grafted bone defects. MEDLINE, CCCT, Scopus, Science Direct, Google Scholar, EMBASE, EBSCO were searched, utilizing the following keywords: bone repair; low-level laser therapy; LLLT; light emitting diode; LEDs; photobiomodulation therapy; in vivo animal studies, bone substitutes, to identify studies between 1994 and 2019. After applying the eligibility criteria, 38 papers included where the results reported according to "PRISMA." The results revealed insufficient and incomplete PBM parameters, however, the outcomes with or without biomaterials have positive effects on bone healing. In conclusion, in vivo animal studies with a standardized protocol to elucidate the effects of PBMT on biomaterials are required initially prior to clinical studies.

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Biomechanical Properties: Effects of Low-level Laser Therapy and Biosilicate^® on Tibial Bone Defects in Osteopenic Rats

Abstract: Biosilicate® alone or in association with low level laser therapy improves biomechanical properties of tibial bone callus in osteopenic rats.

Cited by 9 publications

References 31 publications

Photobiomodulation Therapy Associated with Heterologous Fibrin Biopolymer and Bovine Bone Matrix Helps to Reconstruct Long Bones

Photobiomodulation Therapy Associated with Heterologous Fibrin Biopolymer and Bovine Bone Matrix Helps to Reconstruct Long Bones

Short term histopathological effects of GaAlAs laser on experimentally induced TMJ osteoarthritis in rabbits

Effects of photobiomodulation on bone defects grafted with bone substitutes: A systematic review of in vivo animal studies

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Biomechanical Properties: Effects of Low-level Laser Therapy and Biosilicate® on Tibial Bone Defects in Osteopenic Rats

Abstract: Biosilicate® alone or in association with low level laser therapy improves biomechanical properties of tibial bone callus in osteopenic rats.

Cited by 9 publications

References 31 publications

Photobiomodulation Therapy Associated with Heterologous Fibrin Biopolymer and Bovine Bone Matrix Helps to Reconstruct Long Bones

Photobiomodulation Therapy Associated with Heterologous Fibrin Biopolymer and Bovine Bone Matrix Helps to Reconstruct Long Bones

Short term histopathological effects of GaAlAs laser on experimentally induced TMJ osteoarthritis in rabbits

Effects of photobiomodulation on bone defects grafted with bone substitutes: A systematic review of in vivo animal studies

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Biomechanical Properties: Effects of Low-level Laser Therapy and Biosilicate^® on Tibial Bone Defects in Osteopenic Rats