Biomechanical and biochemical evaluation of the effect of systemic application of omeprazole on the osseointegration of titanium implants

Abstract

Background This study aimed to investigate the effects of systemic omeprazole treatment on the osseointegration of titanium implants. Material and methods After surgical insertion of titanium implants into the metaphyseal part of rats’ both right and left tibial bones, the animals were randomly divided into three equal groups: control (n = 8), omeprazole dosage-1 (n = 8) (OME-1), and omeprazole dosage-2 (n = 8) (OME-2) and totally 48 implants were surgically integrated. The rats in the control group received no treatment during the four-week postoperative experimental period. In the OME-1 and OME-2 groups, the rats received omeprazole in doses of 5 and 10 mg/kg, respectively, every 3 days for 4 weeks. After the experimental period, the rats were euthanized. One rat died in each group and the study was completed with seven rats in each group. Blood serum was collected for biochemical analysis, and the implants and surrounding bone tissue were used for biomechanical reverse-torque analysis. In the biomechanical analysis, implants that were not properly placed and were not osseointegrated were excluded from the evaluation. Results One-way analysis of variance and Tukey’s honestly significant difference test and Student’s t test were used for statistical analysis. The reverse-torque test (control (n = 9), OME-1 (N = 7), and OME-2 (n = 7)) analysis of biochemical parameters (alkaline phosphatase, calcium, phosphorus, aspartate aminotransferase, alanine amino transferase, urea, and creatinine) revealed no significant differences between the groups (control (n = 7), OME-1 (N = 7), and OME-2 (n = 7)) (P > 0.05). Conclusions Omeprazole had no biomechanical or biochemical effects on the osseointegration process of titanium implants.

Evaluation of the Effects of Systemic Irisin Hormone Application on Osseointegration of Titanium Implants: An Experimental Study

“…In addition, while we can analyze a particular thin section histopathologically, we can evaluate the implant and all bone tissues around it in 3D with biomechanical analysis. Hence, biomechanical analysis was preferred in our study 1–6 …”

“…All of the implants were placed in polymethylmethacrylate blocks. To measure the torque of the implants, a turning apparatus was put in place, and, using a digital torque tool (Mark10, NY), a counterclockwise extraction force was applied manually, slowly, and increasingly 3 . The procedure was terminated immediately with the return of the dental implant into the bone socket.…”

“…in addition to factors such as the age and gender of the patient, the physical properties of the implant, the patient's smoking habit, if any, and the use of systemic drugs may also impair osseointegration between the bone and the dental implant. [2][3][4][5][6] Irisin is a C-terminally cleaved protein containing 5 transmembrane proteins of fibronectin type III (FNDC). irisin is produced mainly by skeletal muscle as a result of exercise in mice and possibly also in humans.…”

“…Certain factors adversely impact osseointegration because of their effects on the bone regeneration mechanism. in addition to factors such as the age and gender of the patient, the physical properties of the implant, the patient's smoking habit, if any, and the use of systemic drugs may also impair osseointegration between the bone and the dental implant 2–6 …”

“…Abnormal situations that occur in the bone metabolism will negatively affect the bone tissue and the mechanism that occurs in a dental implant, potentially causing the failure of the implant. [1][2][3] Certain factors adversely impact osseointegration because of their effects on the bone regeneration mechanism. in addition to factors such as the age and gender of the patient, the physical properties of the implant, the patient's smoking habit, if any, and the use of systemic drugs may also impair osseointegration between the bone and the dental implant.…”