The impact of medication on osseointegration and implant anchorage in bone determined using removal torque—A review

Jolic, Martina; Sharma, Sonali; Palmquist, Anders; Shah, Furqan A.

doi:10.1016/j.heliyon.2022.e10844

Cited by 2 publications

(2 citation statements)

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“…The biomechanical stability of implants was assessed using continuous rotational force applied to the exposed implant head at the experimental endpoint 38 . The RTQ values were 2.1 ± 0.5 Ncm in LepR −/− animals and 2.4 ± 0.4 Ncm in LepR +/+ animals (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…However, changes in the extracellular matrix caused by disease and ageing can strongly affect the overall mechanical strength of bone 48 and influence the stability of metal implants without affecting the extent of bone-implant contact. Moreover, different pharmacological agents, with direct and indirect influences on bone metabolism, can affect the biomechanical stability of implants without changing the BIC 38 . In studies using animal models of type 2 diabetes mellitus presenting with hyperglycaemia and obesity, a decrease in the BIC is often reported in the diabetic group 25 , 49 , seemingly reflecting a reduced osseointegration potential in these animals.…”

Section: Discussionmentioning

confidence: 99%

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Leptin receptor gene deficiency minimally affects osseointegration in rats

Jolic,

Ruscsák,

Emanuelsson

et al. 2023

Sci Rep

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Metabolic syndrome represents a cluster of conditions such as obesity, hyperglycaemia, dyslipidaemia, and hypertension that can lead to type 2 diabetes mellitus and/or cardiovascular disease. Here, we investigated the influence of obesity and hyperglycaemia on osseointegration using a novel, leptin receptor-deficient animal model, the Lund MetS rat. Machined titanium implants were installed in the tibias of animals with normal leptin receptor (LepR+/+) and those harbouring congenic leptin receptor deficiency (LepR−/−) and were left to heal for 28 days. Extensive evaluation of osseointegration was performed using removal torque measurements, X-ray micro-computed tomography, quantitative backscattered electron imaging, Raman spectroscopy, gene expression analysis, qualitative histology, and histomorphometry. Here, we found comparable osseointegration potential at 28 days following implant placement in LepR−/− and LepR+/+ rats. However, the low bone volume within the implant threads, higher bone-to-implant contact, and comparable biomechanical stability of the implants point towards changed bone formation and/or remodelling in LepR−/− rats. These findings are corroborated by differences in the carbonate-to-phosphate ratio of native bone measured using Raman spectroscopy. Observations of hypermineralised cartilage islands and increased mineralisation heterogeneity in native bone confirm the delayed skeletal development of LepR−/− rats. Gene expression analyses reveal comparable patterns between LepR−/− and LepR+/+ animals, suggesting that peri-implant bone has reached equilibrium in healing and/or remodelling between the animal groups.

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Section: Resultsmentioning

confidence: 99%