Background This study aimed to investigate the effects of systemic omeprazole treatment on the osseointegration of titanium implants. Material and methods After surgical insertion of titanium implants into the metaphyseal part of rats’ both right and left tibial bones, the animals were randomly divided into three equal groups: control (n = 8), omeprazole dosage-1 (n = 8) (OME-1), and omeprazole dosage-2 (n = 8) (OME-2) and totally 48 implants were surgically integrated. The rats in the control group received no treatment during the four-week postoperative experimental period. In the OME-1 and OME-2 groups, the rats received omeprazole in doses of 5 and 10 mg/kg, respectively, every 3 days for 4 weeks. After the experimental period, the rats were euthanized. One rat died in each group and the study was completed with seven rats in each group. Blood serum was collected for biochemical analysis, and the implants and surrounding bone tissue were used for biomechanical reverse-torque analysis. In the biomechanical analysis, implants that were not properly placed and were not osseointegrated were excluded from the evaluation. Results One-way analysis of variance and Tukey’s honestly significant difference test and Student’s t test were used for statistical analysis. The reverse-torque test (control (n = 9), OME-1 (N = 7), and OME-2 (n = 7)) analysis of biochemical parameters (alkaline phosphatase, calcium, phosphorus, aspartate aminotransferase, alanine amino transferase, urea, and creatinine) revealed no significant differences between the groups (control (n = 7), OME-1 (N = 7), and OME-2 (n = 7)) (P > 0.05). Conclusions Omeprazole had no biomechanical or biochemical effects on the osseointegration process of titanium implants.

This study aimed to investigate the effects of systemic propranolol on the osseointegration of titanium implants. After the surgical insertion of titanium implants into the metaphyseal part of the tibiae of rats, the rats were randomly divided into three equal groups: the control (n ¼ 8), propranolol dosage-1 (PRP-1) (n ¼ 8), and propranolol dosage-2 (PRP-2) (n ¼ 8) groups. In the control group, the rats received no further treatment during the 4-week experimental period after the surgery. After the surgical insertion of the implants, the rats in the PRP-1 and PRP-2 groups were given 5 mg/kg and 10 mg/kg propranolol, respectively, every 3 days for the 4-week experimental period. After the experimental period, the rats were euthanized. Blood sera were collected for biochemical analysis, and the implants and surrounding bone tissues were used for the biomechanical reverse torque analysis. One-way ANOVA and Tukey's honest significant difference test were used for statistical analysis. The student t-test was used to analyze the data obtained from the tests and the controls. There were no significant differences in the reverse torque analysis results and the biochemical parameters (alkaline phosphatase, calcium, and phosphorus) of the groups (P > 0.05). Alkaline phosphatase was, however, found to be higher in test animals compared to the controls (P < 0.05). Also, propranolol did not biomechanically affect the osseointegration of titanium implants, while alkaline phosphatase activity was higher in the test animals.

No abstract

Glass carbomer cement is a new dental material developed from the traditional glass ionomer cements. It has better mechanical and chemical features when compared to the conventional glass ionomer cements. The purpose of this in silico investigation was to examine the influence of glass carbomer and composite resin materials with class I cavity design on stresses happening in the inlay. Finite-element analysis and three-dimensional modelling were used to examine the stress in the glass carbomer and hybrid composite inlays resulting from a 300-N point load on occlusal surfaces. Two different inlay materials, glass carbomer cement and hybrid composite resin, were evaluated. The maximum von Misses stress values in the composite resin inlays were significantly lower than those in the glass carbomer inlays. The results from this study showed that the resistance of the glass carbomer against the forces was higher than that of the composite resin inlays. The stresses were concentrated mostly at similar regions. The obtained results suggest that glass carbomer may be recommended as a preferred filler restorative material in teeth with much structure loss.

The aim of this study was to compare the marginal and internal adaptation of three‐unit fixed dental prostheses (FDPs) fabricated from different metal‐free materials using CAD/CAM methods. A total of 100 three‐unit FDPs were produced from a cubic zirconia, a fiber‐reinforced resin composite, a polyetheretherketone (PEEK), a polyetherketoneketone (PEKK), and a polymer composite material by the CAD/CAM method (n = 20 per material). The zirconia group was considered the control/reference material. Marginal and internal gap values of the produced FDPs were measured using the silicone replica method at ×40 magnification under a stereomicroscope. The obtained data were analyzed using one‐way ANOVA and Tukey's HSD tests. The marginal and internal gap values for the cubic zirconia material were found to be statistically significantly lower than those seen for the PEEK, polymer composite, PEKK, and fiber‐reinforced resin composite materials. While the marginal and internal adaptation of the cubic zirconia material was found to be better than the others, it should be noted that the marginal and internal gap values for all other materials tested were found to be within the clinically acceptable range.

Capecitabine monotherapy is an effective and safe regimen for ER-positive, HER2-negative patients with MBC. Its low toxicity profile compared to other intravenous cytotoxic agents and the ease of its oral administration make this agent a preferable option for both physicians and patients.

Resim 1c Hastanın ellerinin görünümü Resim 1d Protetik tedavi sonrası Resim 1e Hastanın panoramik radyografi görünümü OLGU 2

The aim of this in-silico study was to compare stress distributions in implants and zirconia frameworks of mandibular and maxillary implant-supported crowns. For comparison, vertical and oblique loading forces were used. Three-dimensional finite-element implant models of a mandibular section of bone (D2) and a maxillary section of bone (D4) with missing second molars and their zirconium-based superstructures were used. Zimmer dental implants of 13 mm in length and 4.7 mm in diameter were modelled. A load of 200 N was applied toward vertical and oblique (30 to the vertical) directions. Maximum and minimum von Mises stress values of the implants and the zirconia framework were calculated. The highest stress value was concentrated in the zirconia framework of the maxillary implant-supported model with the oblique loading force (301.17 MPa). The lowest stress value was concentrated in the mandibular implant-supported model. And the stress values in the maxilla were higher than in the mandible. The maxilla (D4) showed higher stress values than in the mandible (D2), because the trabecular bone is weaker and less resistant to deformation than the cortical bone. Stress values with oblique loading forces were higher than with vertical loading forces. Because of the high Young's modulus of zirconia (low elastic properties), zirconia frameworks showed higher stress values than the implants.Keywords: finite element analysis (FEA); stress distribution; zirconia framework; bone quality; vertical and oblique loading force 3D three dimensional D2 mandibular section of bone D4 maxillary section of bone FE finite element FPDs fixed partial dentures Y-TZP yttrium oxide partially stabilized