Biomaterial developments for bone tissue engineering

Burg, Karen J. L.; Porter, Scott E.; Kellam, James F

doi:10.1016/s0142-9612(00)00102-2

Cited by 1,478 publications

(988 citation statements)

References 85 publications

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“…This scaffold should possess a network of interconnected pores to permit cell migration and the transport of nutrients to the cells. Pore size is very tissue-type specific [8], but Karageorgiou and Kaplan [9] suggested that pore sizes larger than 300 lm are preferable to enhance bone and capillary formation.…”

Section: Introductionmentioning

confidence: 99%

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Microporous bacterial cellulose as a potential scaffold for bone regeneration

et al. 2010

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a b s t r a c tNanoporous cellulose biosynthesized by bacteria is an attractive biomaterial scaffold for tissue engineering due to its biocompatibility and good mechanical properties. However, for bone applications a microscopic pore structure is needed to facilitate osteoblast ingrowth and formation of a mineralized tissue. Therefore, in this study microporous bacterial cellulose (BC) scaffolds were prepared by incorporating 300-500 lm paraffin wax microspheres into the fermentation process. The paraffin wax microspheres were subsequently removed, and scanning electron microscopy confirmed a microporous surface of the scaffolds while Fourier transform infrared spectroscopy verified the elimination of paraffin and tensile measurements showed a Young's modulus of approximately 1.6 MPa. Microporous BC and nanoporous (control) BC scaffolds were seeded with MC3T3-E1 osteoprogenitor cells, and examined by confocal microscopy and histology for cell distribution and mineral deposition. Cells clustered within the pores of microporous BC, and formed denser mineral deposits than cells grown on control BC surfaces. This work shows that microporous BC is a promising biomaterial for bone tissue engineering applications.

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Section: Introductionmentioning

confidence: 99%

“…A variety of materials has been examined as potential scaffolds for bone tissue engineering and include ceramics, composites and polymers [8]. These materials -derived from synthetic or natural starting materials -have different properties and exhibit different degradation rates.…”

Section: Introductionmentioning

confidence: 99%

Microporous bacterial cellulose as a potential scaffold for bone regeneration

et al. 2010

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“…However, drawbacks of this option include lack of supply, donor site morbidity and infection. Additionally, vascularized autografts often require complex alterations to reconstruct the external shape or cortical distribution of the defect site [1,5]. As alternatives, allogeneic and xenogeneic bone grafts face their own challenges such as lack of vascularization/blood supply, immunogenicity, disease transmission and, in some cases, donor shortage [6].…”

Section: Bone Tissue Engineering (Bte)mentioning

confidence: 99%

“…Synthetic biomaterials are often made up of ceramic (calcium phosphate, calcium sulphate, β-tricalcium phosphate, synthetic hydroxyapatite, among others) or polymer (polycaprolactone, gelatine, sodium hyaluronate, collagen, among others) components, either individually or in combination. Various bone graft substitutes used through the year 2010 have been presented in recent literature [5]. The most current progress within this area was surveyed by searching on the keyword 'bone' on the FDA's 510(k) cleared medical devices website between the years 2011 and 2015.…”

Section: Biomaterial-based Therapiesmentioning

confidence: 99%

The Potential Impact of Bone Tissue Engineering in the Clinic

et al. 2016

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Bone tissue engineering (BTE) intends to restore structural support for movement and mineral homeostasis, and assist in hematopoiesis and the protective functions of bone in traumatic, degenerative, cancer, or congenital malformation. While much effort has been put into BTE, very little of this research has been translated to the clinic. In this review, we discuss current regenerative medicine and restorative strategies that utilize tissue engineering approaches to address bone defects within a clinical setting. These approaches involve the primary components of tissue engineering: cells, growth factors and biomaterials discussed briefly in light of their clinical relevance. This review also presents upcoming advanced approaches for BTE applications and suggests a probable workpath for translation from the laboratory to the clinic.

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“…[1][2][3][4] In the scaffolds, a parameter that is important factor of the scaffolds is constructive property such as surface area, porosity, and the percentage of void space. Pores are necessary for bone regeneration because that they permit for migration and proliferation of osteoblasts.…”

Section: Introductionmentioning

confidence: 99%

In vivo Bone Regeneration by Using Chitosan Scaffolds with KUSA-A1 Oesteoblast Cells

Lim¹,

Oh²,

Choi³

et al. 2012

Polymer Korea

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For bone regeneration from KUSA-A1 oesteoblast cells (KUSA), chitosan (CS) scaffolds possessing different surface properties, sponge-type (CSS) and nonwoven-type (CSNW), were manufactured. Surface area and pore size of CSNW were larger than those of CSS. On the other hand, the pore volume of CSNW was smaller than that of CSS. Cell attachment evaluation showed CSNW was more adequate then CSS, and this was attributed to the large surface area. For in vivo investigation, KUSA were seeded into CS scaffolds in wells followed by a week of cell culture. Obtained CS scaffolds with KUSA were implanted on the subcutaneous tissue of BALB/C nude mice. After surgery, implanted scaffolds were harvested and assayed by immunological staining. Network stability of CSS was better than that of CSNW, even if CSS scaffolds were destroyed between 4 and 6 weeks. Calcification was observed after 4 and 8 weeks for CSNW and CSS, respectively.

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Biomaterial developments for bone tissue engineering

Cited by 1,478 publications

References 85 publications

Microporous bacterial cellulose as a potential scaffold for bone regeneration

Microporous bacterial cellulose as a potential scaffold for bone regeneration

The Potential Impact of Bone Tissue Engineering in the Clinic

In vivo Bone Regeneration by Using Chitosan Scaffolds with KUSA-A1 Oesteoblast Cells

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