Biomarkers of dairy fat intake and risk of cardiovascular disease: A systematic review and meta analysis of prospective studies

Liang, Jingjing; Zhou, Quan; Amakye, William Kwame; Su, Yi-xiang; Zhang, Zheqing

doi:10.1080/10408398.2016.1242114

Cited by 51 publications

(31 citation statements)

References 39 publications

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“…Healthy eating guidelines recommend reducing the dietary content of saturated fatty acids (animal fats, coconut, and palm oil) and trans fats (used in cakes and pastries) while increasing the intake of mono-and polyunsaturated fatty acids [5]. A reduction of the intake of carbohydrates (especially the simple ones) is also advised, as well as more fiber-rich foods in the diet [6,7] as soluble fiber fractions are known to lower the low-density lipoprotein cholesterol (LDL-C) concentration and the glycemic index of foods [8][9][10]. It is also important to ensure that the daily protein intake meets that recommended for healthy adults, i.e.…”

Section: Introductionmentioning

confidence: 99%

Effect of 12-Week Interventions Involving Nordic Walking Exercise and a Modified Diet on the Anthropometric Parameters and Blood Lipid Profiles in Overweight and Obese Ex-Coal Miners

et al. 2020

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Background: Overweight and obesity after retirement are likely to be caused by unhealthy eating habits and the energy intake exceeding the energy expenditure. Objectives: This study was designed to assess the effects of two 12-week interventions involving, respectively, either regular physical activity or a modified lower-calorie diet on the anthropometric parameters and blood lipid profiles in overweight and obese retired miners with lipid disorders. Design:The study participants (n = 30, aged 58.7 ± 4.1 years, body height 174.8 ± 7.3 cm, body weight 96.6 ± 13.9 kg) were randomly assigned to 2 intervention groups: the Nordic walking group (NW), which exercised with intensity from 60 to 70% of participants' maximal heart rates for 1 h 3 times a week, and the modified diet group (MD). Modification of the diet consisted of reducing the daily energy intake by 30%, increasing the dietary content of mono-and polyunsaturated fatty acids and dietary fiber, and reducing the proportion of saturated fatty acids. The variables assessed at baseline and after 6 and 12 weeks were: anthropometric parameters (body weight, fat mass content [FM], fat percentage [BF], BMI, waist circumference [WC], hip circumference [HC], and waist-to-hip ratio [WHR]) and blood lipid indicators (total cholesterol [TC], triglycerides [TG], low density lipoprotein cholesterol [LDL-C], and high density lipoprotein cholesterol [HDL-C]). Results: The body weight of the participants in the NW was lower at week 12 by an average of 5 kg, BMI 7%. In the MD, the postintervention concentrations of TC and TG were within the reference range. Conclusion: Both 12-week interventions improved the anthropometric parameters and blood lipid profiles of retired heavy manual workers, with the improvements being more pronounced in the dieting group.

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Section: Introductionmentioning

confidence: 99%

Effect of 12-Week Interventions Involving Nordic Walking Exercise and a Modified Diet on the Anthropometric Parameters and Blood Lipid Profiles in Overweight and Obese Ex-Coal Miners

et al. 2020

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“…Furthermore, positive linear associations were observed between palmitoleic acid and IS [for plasma cholesterol ester fraction: HR = 1.86 (95% CI: 1.20–2.87); p = 0.003; for phospholipid fraction: HR = 1.52 (95% CI: 0.99–2.34); p = 0.005] in 3,870 participants from the Minneapolis field center of the Atherosclerosis Risk in Communities study ( 35 ). Similarly, a previous meta-analysis (13 prospective studies; n = 7,680 CVD cases) found no association between trans-palmitoleic acid, CHD, and stroke ( 33 ). Trans-palmitoleic acid levels did not correlate with the risk of total stroke, IS, or hemorrhagic stroke in two large cohort studies [i.e., the Health Professionals Follow-Up Study (51,529 men) and the Nurses' Health Study (121,700 women)] ( 32 ).…”

Section: Discussionmentioning

confidence: 81%

“…Similarly, heptadecanoic acid level was not related to the risk of total stroke, IS, or hemorrhagic stroke in the Health Professionals Follow-Up Study (51,529 men) and the Nurses' Health Study (121,700 women) ( 32 ). However, a previous meta-analysis (13 prospective studies; 7,680 CVD cases) showed a marginal inverse correlation between heptadecanoic acid and CVD events (relative risk = 0.82, 95% CI: 0.68–0.99) ( 33 ). Data on the associations of myristoleic acid with CVD are missing.…”

Section: Discussionmentioning

confidence: 99%

Monounsaturated Fatty Acid Levels May Not Affect Cardiovascular Events: Results From a Mendelian Randomization Analysis

et al. 2020

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Background/Aim: Several observational studies evaluated the links between serum monounsaturated fatty acids (MUFAs) and cardiovascular events with controversial results. In the present study, Mendelian randomization (MR) analysis was applied to obtain unconfounded estimates of the causal associations of genetically determined serum MUFAs with coronary heart disease (CHD), myocardial infarction (MI), cardioembolic stroke (CS), and ischemic stroke (IS). Methods: Four MUFAs were studied (i.e., 10-heptadecenoate, myristoleic, oleic, and palmitoleic acid). Data from the largest genome-wide association studies on MUFAs, CHD, MI, and stroke were analyzed. Inverse variance weighted method (IVW), weighted median (WM)-based method, MR-Egger, as well as MR-pleiotropy residual sum and outlier were applied. To rule out the impact of single-nucleotide polymorphism (SNP), the leave-one-out method was also performed. Results: Genetically higher-serum 10-heptadecenoate levels did not affect the risk of CHD (IVW = Beta: −0.304, p = 0.185), MI (IVW = Beta: −0.505, p = 0.066), CS (IVW = Beta: −0.056, p = 0.945), and IS (IVW = Beta: −0.121, p = 0.767). Similarly, no significant associations were observed for myristoleic acid (CHD: IVW = Beta: 0.008; MI: IVW = Beta: 0.041; CS: IVW = Beta: 0.881; IS: IVW = Beta: 0.162), oleic acid (CHD: IVW = Beta: −0.2417; MI: IVW = Beta: −0.119; CS: IVW = Beta: 1.059; IS: IVW = Beta: 0.008491), and palmitoleic acid (CHD: IVW = Beta: −0.06957; MI: IVW = Beta: −0.01255; CS: IVW = Beta: 1.042; IS: IVW = Beta: −0.1862). A low likelihood of heterogeneity and pleiotropy was reported, and the observed associations were not driven by single SNPs. Conclusions: In the present MR analysis, serum MUFA levels were not associated with the risk of CHD, MI, CS, and IS. Further research, evaluating more MUFAs, is required to elucidate the links between MUFAs and CVD to contribute to health policy decisions in reducing CVD risk.

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“…The result of a prospective cohort study in the United States on 2907 people over the age of 65 has been shown that there were no signi cant relationship between pentadecanoic, heptadecanoic and trans-palmitoleic phospholipids (as biomarkers of dairy fat intake) with total mortality and incidence of CVDs [30]. In another meta-analysis study of 13 studies, it was observable that higher intake of dairy fat was not associated with an increased risk of cardiovascular disease [31] .…”

Section: Buttermentioning

confidence: 99%

The Effect of Edible Lipids on Atherogenic Index of Plasma: Results From RaNCD Cohort Study

Sahargahi

Pasdar

Moradinazar

et al. 2020

Preprint

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Background: The amount and type of lipids consumed has a great impact on serum lipid profile and risk of cardiovascular diseases (CVDs). A novel index named atherogenic index of plasma (AIP) is better predictors of CVD risk factors than lipids alone. This study aimed to investigate the effect of edible oils on AIP. Methods: This cross-sectional study conducted on preliminary phase of Ravansar Non-Communicable Disease (RaNCD) cohort study. The amount of consumption of edible lipids was determined based on validated Food Frequency Questionnaire (FFQ). Lipid profiles including triglyceride (TG), and lipoprotein cholesterol (HDL-C) were measured, and AIP was calculated as log10 (TG/HDL-C).Results: A total of 9996 individuals, 4738(47.4%) were male. The mean of AIP was 0.98±0.6 (range from -1.73 to 4.15) that in females (0.97 ± 0.6) was lower than males (1.10 ± 0.6). After controlling for confounding and affecting variables, the AIP index decreased with increasing consumption of a local oil named Kermanshahi oil [β(CI 95% ): -0.006(-0.008, -0.003)], butter[β(CI 95% ): -0.008(-0.011, -0.005)] and not statistically significant decrease with Hydrogenated or partial hydrogenated oil [β(CI 95% ): -0.008(-0.001, 0.001)] but the AIP index increased with un-hydrogenated oil [β(CI 95% ): 0.001(-0.001, 0.001)]Conclusion: Kermanshahi oil and butter have decreasing effect on AIP, the effect of margarine was neutral, hydrogenated vegetable oil has trace decreasing effect whereas un-hydrogenated vegetable oil has increasing effect on it. So, consumption of Kermanshahi oil may be associated with lower cardiovascular risk.

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Biomarkers of dairy fat intake and risk of cardiovascular disease: A systematic review and meta analysis of prospective studies

Abstract: Higher dairy fat exposure is not associated with an increased risk of CVD.

Cited by 51 publications

References 39 publications

Effect of 12-Week Interventions Involving Nordic Walking Exercise and a Modified Diet on the Anthropometric Parameters and Blood Lipid Profiles in Overweight and Obese Ex-Coal Miners

Effect of 12-Week Interventions Involving Nordic Walking Exercise and a Modified Diet on the Anthropometric Parameters and Blood Lipid Profiles in Overweight and Obese Ex-Coal Miners

Monounsaturated Fatty Acid Levels May Not Affect Cardiovascular Events: Results From a Mendelian Randomization Analysis

The Effect of Edible Lipids on Atherogenic Index of Plasma: Results From RaNCD Cohort Study

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