Biomarkers for Risk Assessment in Molecular Epidemiology of Cancer

Verma, Mukesh

doi:10.1177/153303460400300512

Cited by 15 publications

(7 citation statements)

References 63 publications

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“…For example, DNA adducts and some enzymes such as sulfotransferase A1 and epoxide hydroxylase have been validated and used as biomarkers for cancer detection [32]. The current advances in proteomics technology enable the identification of specific biomarkers from complex biological specimens [28].…”

Section: Introductionmentioning

confidence: 99%

Plasma haptoglobin and immunoglobulins as diagnostic indicators of deoxynivalenol intoxication

et al. 2008

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This study aimed to discover potential biomarkers for dioxynivalenol (DON) intoxication. B6C3F1 male mice were orally exposed to 0.83, 2.5 and 7.5 mg/kg body weight (bw) DON for 8 days and the differential protein expressions in their blood plasma were determined by SELDI - Time-of-Flight/Mass Spectrometry (TOF/MS) and the immunoglobulins (Igs) G, A, M and E in the serum were investigated. 11.7 kDa protein was significantly highly expressed according to DON administration and this protein was purified by employing a methyl ceramic HyperD F column with using optimization buffer for adsorption and desorption. The purified protein was identified as a haptoglobin precursor by peptide mapping with using LC/Q-TOF/MS and MALDI-TOF/MS and this was confirmed by western blotting and ELISA. IgG and IgM in serum were decreased in a dose-dependent manner and IgA was decreased at 7.5 mg/kg bw DON administration, but the IgE level was not changed. To compare the expressions of haptoglobin and the Igs patterns between aflatoxin B1 (AFB1), zearalenone (ZEA) and DON intoxications, rats were orally administered with AFB1 1.0, ZEA 240 and DON 7.5 mg/kg bw for 8 days. Haptoglobin was increased only at DON 7.5 mg/kg bw, while it was slightly decreased at ZEA 240 mg/kg bw and it was not detected at all at AFB1 1.0 mg/kg bw. IgG and IgA were decreased by DON, but IgG, IgA, IgM and IgE were all increased by AFB1. No changes were observed by ZEA administration. These results show that plasma haptoglobin could be a diagnostic biomarker for DON intoxication when this is combined with examining the serum Igs.

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Section: Introductionmentioning

confidence: 99%

Plasma haptoglobin and immunoglobulins as diagnostic indicators of deoxynivalenol intoxication

et al. 2008

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“…It is well known that many factors can contribute to carcinogenesis in humans. In molecular epidemiology studies, biological effects are more frequently measured by biomarkers, which are divided into three categories: measures of internal dose, early biological response, and host susceptibility (6,7). Many studies have found the associations between PAH environmental exposure, whose internal dose is usually quantified by 1-hydroxypyrene (1-OHP) in urine, and an increase in the levels of carcinogen-DNA adducts, sister chromatid exchange, and chromosomal aberrations (8)(9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

Path Analysis of Biomarkers of Exposure and Early Biological Effects among Coke-Oven Workers Exposed to Polycyclic Aromatic Hydrocarbons

Qiu

Leng

Wang

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Many host factors or biomarkers are involved in the process of early DNA damage induced by occupational exposure to polycyclic aromatic hydrocarbons (PAH) as seen in coke-oven workers. This paper aimed to identify complicated causal interrelationship of various biomarkers using the path analysis. In this analysis, we included 235 subjects (166 cokeoven workers and 69 nonexposed controls) whose data on the comet assay (e.g., Olive tail moment) and cytogenetic analysis of peripheral blood lymphocytes as well as urinary 1-hydroxypyrene (1-OHP) were available. The path analysis showed that coke-oven exposure and tobacco smoke were both significant predictors of the concentrations of urinary 1-OHP (P < 0.05), with a coefficient of determination of 0.75. The factors having significant influence on the Olive tail moment were in the following order: urinary 1-OHP > XRCC1-exon 9 variant genotype > ERCC2-exon 10 variant genotype > XRCC1-exon 6 variant genotype, with a coefficient of determination of 0.22. The variables of relative importance in influencing on cytokinesis-block micronucleus frequencies were in the following order: coke-oven exposure > urinary 1-OHP > age > mEH3 variant genotype > ERCC2-exon 10 variant genotype > XRCC1-exon 6 variant genotype, with a coefficient of determination of 0.27. These results indicated that exogenous agents, especially the coke-oven exposure, played a more important role than the genotypes in the induction of early genetic damage. In conclusion, the path analysis seemed to be an alternative statistical approach for the ascertainment of complicated association among related biomarkers for the assessment of occupational exposure. (Cancer Epidemiol Biomarkers Prev 2007;16(6):1193 -9)

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“…Several attempts have been made to define and classify cancer biomarkers using different approaches, but general consensus has yet to be established. Broadly, any biologically derived entity or processes which lead to a cancer diagnosis (in prognosis, screening and risk assessment), at the stage of diagnosis or post diagnosis (in therapy and treatment module) are potential candidates as cancer biomarkers [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 ]. Due to the vast explosion of knowledge over the past several decades, collectively and in multiple spheres of the biomedical sciences and technology development, different methods have been suggested to classify cancer biomarkers.…”

Section: Classification Of Cancer Biomarkersmentioning

confidence: 99%

Cancer Biomarkers: Are We Ready for the Prime Time?

Mishra

Verma

2010

Cancers

Self Cite

201

140

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A biomarker is a characteristic that is objectively measured and evaluated as an indicator of normal biologic processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention. In cancer, a biomarker refers to a substance or process that is indicative of the presence of cancer in the body. A biomarker might be either a molecule secreted by a tumor or it can be a specific response of the body to the presence of cancer. Genetic, epigenetic, proteomic, glycomic, and imaging biomarkers can be used for cancer diagnosis, prognosis and epidemiology. These markers can be assayed in non-invasively collected biofluids. However, few cancer biomarkers are highly sensitive and specific for cancer detection at the present time. Consequently, biomarkers are not yet ready for routine use due to challenges in their clinical validation for early disease detection, diagnosis and monitoring to improve long-term survival of patients.

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Biomarkers for Risk Assessment in Molecular Epidemiology of Cancer

Cited by 15 publications

References 63 publications

Plasma haptoglobin and immunoglobulins as diagnostic indicators of deoxynivalenol intoxication

Plasma haptoglobin and immunoglobulins as diagnostic indicators of deoxynivalenol intoxication

Path Analysis of Biomarkers of Exposure and Early Biological Effects among Coke-Oven Workers Exposed to Polycyclic Aromatic Hydrocarbons

Cancer Biomarkers: Are We Ready for the Prime Time?

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