Bioluminescence and ventilator-associated pneumonia caused by oral biofilm in ICU during COVID-19 -Is there a possible relationship?

Abstract

Ventilator-associated pneumonia (VAP) has been claiming many lives in the ICU during COVID-19. Oral biofilm and bacterial contamination that can be passed on from the oral cavity to the lungs during endotracheal intubation has been found to be the main culprit. Bioluminescence-based assays are emerging as potential clinical diagnostics methods. Hence, we hypothesize that the bioluminescent imaging technique can be used in the ICU to determine the load of biofilm-associated with patients undergoing endotracheal intubation. Early detection of such infections and their management can effectively bring down mortality and influence the death rate in ICU caused due to VAP. Government agencies and policymakers should be made to take this issue of deaths in the ICU due to VAP more seriously and act judiciously to methods such as bioluminescence based on sound scientific evidence.

Biofilms possibly harbor occult SARS-CoV-2 may explain lung cavity, re-positive and long-term positive results

“…Some COVID-19 patients had an elevated level of inflammatory cytokines and biomarkers associated with bacterial co-infection (Mirzaei et al, 2020). Joseph et al proposed that bioluminescent imaging technique may be considered as a promising method to confirm the relevant biofilm load of COVID-19 patients, providing new strategy for clinical diagnosis (Joseph and Steier, 2022). The hypothesis that SARS-CoV-2 may co-exist in biofi lms with other microorganisms depends on available evidences and clinical observation.…”

Chrysoeriol alleviated inflammation in infantile pneumonia by inhibiting PI3K/AKT/mTOR signaling pathway

“…Pneumonia is one of the most common illnesses in infants and children. The main treatment strategy consists of symptomatic and anti-infection treatments, as well as prevention of complications [13]. The incidence of severe pneumonia is high, and the existing antibacterial drugs rarely achieve good therapeutic effects due to the existence of drug resistance.…”