Biology of hypopigmentation

Clinical and histopathologic characteristics of nevus depigmentosus

“…[14][15][16][17] ND is generally known to be stable in its relative size and distribution throughout life. 1,3 Our data also support this description. Most of the patients remained stable without any change in size, number, shape, or distribution of lesions.…”

“…It has been proposed that the pathophysiology of ND is associated with a developmental defect of the fetal melanocytes, in particular, a defect in the transfer of melanosomes from melanocytes to keratinocytes. 2,3,5 However, besides functional alteration of melanocytes, our investigation provides a possible role of decreased number of melanocyte in the pathogenesis of ND. There was no significant difference in histologic findings or dermal inflammatory infiltrates between ND skin and perilesional normal skin indicating that immunologic or inflammatory process may not be involved in the pathogenesis of ND.…”

“…3 Clinical diagnostic criteria commonly accepted and proposed by Coupe 4 in 1976 are: (1) leukoderma present at birth or onset early in life; (2) no alteration in distribution of leukoderma throughout life; (3) no alteration in texture, or change of sensation, in the affected area; and (4) no hyperpigmented border around the achromic area.…”

Validation of a Questionnaire to Diagnose the Baumann Skin Type in All Ethnicities and in Various Geographic Locations

“…Although skin tone varies among various ethnicities, the underlying biology of the skin remains the same in all ethnicities with the exception of differences in skin color and the incidence of post -inflammatory hyperpigmentation. Skin color in darker-pigmented individuals occurs because melanocytes produce more melanin, the melanosomes are larger and more heavily melanized, and undergo degradation at a slower rate than in lighter skinned individuals [1]- [3]. Asians, Hispanics and African Americans suffer from the same skin issues such as an impaired barrier, tendency to inflammation and increased sebum production as other skin colors do.…”

Study of Dermatological Quality of Life in Patients With Vitiligo Attending the Out Patient Department of Dermatology in a Tertiary Care Hospital

“…In 30% of the cases inheritance is thought to be polygenic or autosomal dominant with incomplete penetrance and variable expression. [3,4] It causes considerable amount of social stigma and leads to low self-esteem in majority of people.…”