Clinical and histopathologic characteristics of nevus depigmentosus

Kim, Sung Kwon; Kang, Hee Young; Lee, Eun‐So; Kim, You Chan

doi:10.1016/j.jaad.2006.04.053

Cited by 67 publications

(64 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, clinical characteristics and histopathologic findings should be considered together to differentiate vitiligo from nevus depigmentosus because melanocytes can exist in a small number of vitiligo lesions. 15 There was a significant difference in the incidence of dermal inflammation between vitiligo skin and perilesional normal skin. Thus, we divided vitiligo patients into vitiligo subgroups: vitiligo with inflammation and without inflammation.…”

Section: Discussionmentioning

confidence: 97%

“…It may develop at various ages, which often makes the differential diagnosis of vitiligo challenging. 14,15 It is important to distinguish vitiligo from nevus depigmentosus because the prognosis and treatment of these 2 entities differ. Vitiligo is progressive and requires treatment, whereas nevus depigmentosus is stable and generally does not require treatment.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Histopathologic Features in Vitiligo

Kim¹,

Kim²,

Kang³

et al. 2008

The American Journal of Dermatopathology

Self Cite

View full text Add to dashboard Cite

Nevus depigmentosus is a congenital disorder characterized by a nonprogressive hypopigmented lesion, which may not be apparent at birth. Thus, it is sometimes difficult to differentiate vitiligo from nevus depigmentosus only by clinical features. We postulated that the histologic changes in lesional and perilesional skin might be different in the 2 conditions. We took biopsies from both lesional and perilesional skin of 100 cases of vitiligo to assess the number of melanocytes, the amount of melanin, dermal inflammatory infiltrate, and other changes. We compared them with 30 cases of nevus depigmentosus. Histologically, lesions of vitiligo showed more basal hypopigmentation and dermal inflammation than perilesional normal skin. With Fontana-Masson staining, 16% of cases of vitiligo showed the presence of melanin. The ratio of pigmented area to epidermal area was 0.06% in vitiligo, whereas 17% in perilesional normal skin and 8.9% in nevus depigmentosus. In NKI/beteb staining, 12% of vitiligo showed the presence of melanocytes, and their average number was 7.68 per square millimeter. The number of melanocytes was also decreased in nevus depigmentosus but not as much as in vitiligo. We also confirmed the presence of melanocytes in 1 of 3 cases of vitiligo by electron microscopy. In conclusion, there are a few melanocytes and melanin in some cases of vitiligo. Therefore, the diagnosis of vitiligo should be made considering these points.

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Histopathologic Features in Vitiligo

Kim¹,

Kim²,

Kang³

et al. 2008

The American Journal of Dermatopathology

Self Cite

View full text Add to dashboard Cite

show abstract

“…[122][123][124][125] All show neither alteration in skin texture nor in sensation. Nevus anemicus is a nonprogressive developmental anomaly seen as one or more patches of varying sizes and shapes distinctly paler than surrounding skin.…”

Section: Other Manifestations Of Tscmentioning

confidence: 99%

“…Nevus depigmentosus is a nonfamilial quasidermatomal leukoderma often evident at birth or early in life, solitary or multiple, in irregular and geographic shapes. 123 However, shape is not a characteristic feature in its diagnosis; it may be irregular, round, guttate, polygonal, or linear, most commonly in a segmental or an isolated pattern. This well circumscribed hypomelanosis remains stable throughout life in relative size and in anatomic distribution.…”

Section: Other Manifestations Of Tscmentioning

confidence: 99%

Tuberous sclerosis complex: Advances in diagnosis, genetics, and management

Schwartz¹,

Fernández²,

Kotulska³

et al. 2007

Journal of the American Academy of Dermatology

345

304

View full text Add to dashboard Cite

“…Lezyonel deride yapılan histolojik çalısmalarda, perilezyonel deriye göre melanozom yoğunluğunda belirgin azalma ancak melanosit sayısında değişken sonuçlar gözlenmiştir. ND'nin patofizyolojisinin fetal melanositlerdeki gelişimsel bir defekte, özellikle melanositlerden keratinositlere melanozom transferindeki bir defekte bağlı olabileceği düşünülmektedir 24 . Lezyonlar homojen bir şekilde hipomelanotiktir ve Wood ışığı muayenesinde, vitiligoda görülen tebeşir beyazı belirginleşmenin aksine lezyonda kirli beyaz bir belirginleşme gözlenir.…”

Section: Nevus Depigmentozusunclassified

Hypopigmented Disorders Except Vitiligo

Doğramacı¹

2011

Turkderm

View full text Add to dashboard Cite

ÖzetÇocuklardaki hipopigmentasyon bozuklukları çeşitli konjenital ve edinsel hastalıklara bağlı olarak ortaya çıkabilir. Bu hipopigmente lezyonlar yaygınlıklarına göre generalize ve lokalize olmak üzere iki gruba ayrılabilir. Klinik bulgulardaki farklılıklar, pigment kaybının derecesi, ilişkili morfolojik bulgular hastalıkların ayrımında kullanılan önemli göstergelerdir. Bu derlemede çocuklarda hipopigmentasyon ile seyreden vitiligo dışındaki deri hastalıkları irdelenmektedir. Sum maryHypopigmentation disorders in children can be due to a wide variety of congenital and acquired diseases. They can be classified on the basis of lesion extent, and can generally be divided into disorders with localized or generalized lesions. Clinical findings, comprising the degree of pigment loss and associated morphological findings are used to further distinguish the disorders. This review deals with skin diseases with hypopigmentation other than vitiligo as the main clinical presenting feature in children. (

show abstract

Clinical and histopathologic characteristics of nevus depigmentosus

Cited by 67 publications

References 12 publications

Histopathologic Features in Vitiligo

Histopathologic Features in Vitiligo

Tuberous sclerosis complex: Advances in diagnosis, genetics, and management

Hypopigmented Disorders Except Vitiligo

Contact Info

Product

Resources

About