Biology of basal cell carcinoma (Part II)

Miller, Stanley J.

doi:10.1016/0190-9622(91)70022-t

Cited by 130 publications

(88 citation statements)

References 186 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…88 Men and women are affected in roughly equal proportions with the majority of tumors occurring in the head and neck region. 2,3,20 In our experience, male subjects tend to manifest more frequent localization to the left side of the face, which may reflect the fact that they were driving vehicles in North America prior to the advent of sun screens. Roughly onequarter of cases occur on the nose, the most frequently involved site.…”

Section: Uv Light-induced Mutagenesis and Biologic Transformationmentioning

confidence: 60%

“…2, 3 The recurrence rate reflects margin positivity after attempted surgical excision and varies by histologic type, being highest for the aggressive growth variants (for example 26.5% for infiltrative BCCs) and lowest in the indolent growth variants (eg 6.4 and 3.6% for nodular and superficial BCC, respectively). 32 Following Mohs micrographic surgery, the recurrence rate is said to be in the 1% range.…”

Section: Recurrent Bccmentioning

confidence: 99%

“…32 Following Mohs micrographic surgery, the recurrence rate is said to be in the 1% range. 2, 3 The recurrence rates may also differ based upon the anatomic site, particularly as regards lesions of the nose and ears, 2,3,20 where higher recurrence rates may reflect peculiarities of the anatomy or a natural hesitancy on the part of clinicians to perform mutilating surgical procedures in these locations. While most recurrences are seen within 3 years following the original operative procedure, some 20% of recurrences manifest themselves between 6 and 10 years after the original surgery.…”

Section: Recurrent Bccmentioning

confidence: 99%

“…Roughly onequarter of cases occur on the nose, the most frequently involved site. [2][3][4][5][6] Less prevalent overall in more darkly pigmented races, the histologic types of BCC seen in Africans and Hispanics have a similar histomorphology. 89 Other Risk Factors for Sporadic BCC…”

Section: Uv Light-induced Mutagenesis and Biologic Transformationmentioning

confidence: 99%

“…[2][3][4] After a rise in incidence of roughly 20% between 1971 and 1977, 5 by 1998 roughly one million new cases were being diagnosed annually in the United States. 6 In consequence of its high incidence, BCC, although eminently curable when the diagnosis is made promptly and the lesion treated in its early phase, constitutes an enormous financial burden on the health care system.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Basal cell carcinoma: biology, morphology and clinical implications

2006

View full text Add to dashboard Cite

Basal cell carcinoma (BCC) is the most common malignant neoplasm of humans. Rising dramatically in incidence in North America, as likely reflects changing habits of the population and a move from more northerly climes to the sunbelt of the Southern and Southwestern United States, the incidence is surely to rise even higher in the future. The last decade has seen significant advances in our understanding of BCC biology and novel approaches to therapy, which hinge upon accurate diagnosis and subclassification by pathologists. The purpose of this review article is to summate the research advances in our understanding of BCC biology and to acquaint pathologists and clinicians to the practical issues in BCC diagnosis and subclassification which flow there from.

show abstract

Section: Uv Light-induced Mutagenesis and Biologic Transformationmentioning

confidence: 60%

Section: Recurrent Bccmentioning

confidence: 99%

Section: Recurrent Bccmentioning

confidence: 99%

Section: Uv Light-induced Mutagenesis and Biologic Transformationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Basal cell carcinoma: biology, morphology and clinical implications

2006

View full text Add to dashboard Cite

show abstract

Predictors of Extensive Subclinical Spread in Nonmelanoma Skin Cancer Treated With Mohs Micrographic Surgery

Batra¹

2002

Arch Dermatol

158

130

View full text Add to dashboard Cite

Background: In nonmelanoma skin cancer, the clinically visible portion may represent a small fraction of microscopic tumor spread. Previous studies have examined individual risk factors for subclinical spread based on patient and tumor characteristics. However, these risk factors have not been prioritized or studied in combination.Objective: To identify the most predictive risk factors for extensive subclinical tumor spread.Design: Retrospective analysis of 1131 Mohs micrographic surgical cases. Variables analyzed included patient age, sex, and immune status and lesion size, location, histologic subtype, and recurrence. Logistic regression was applied to identify important combinations of tumor characteristics and to quantify relative odds of spread.Setting: Academic referral center.Patients: Consecutive sample of all referred patients treated by a single Mohs micrographic surgeon in a 3-year period.Main Outcome Measure: Number of Mohs micrographic surgical layers required to clear a tumor, with 3 or more layers defined as extensive subclinical spread.Results: The highest-risk tumors, with odds ratios greater than 6.0, were basosquamous and morpheaform basal cell carcinoma (BCC) on the nose, morpheaform BCC on the cheek, and those with a preoperative size greater than 25 mm. Other important risk factors were recurrent and nodular BCC on the nose; location on the eyelid, temple, or ear helix; neck tumors and recurrent BCC in men; and tumor size greater than 10 mm. Patients younger than 35 years were at lower risk. Increasing age and immunocompromise were not significant predictors. Conclusion:Identification of lesions likely to exhibit extensive subclinical spread can help guide management to ensure complete tumor eradication and thereby reduce the risk of recurrence and its associated morbidity and cost.

show abstract