Biology and Treatment of Eosinophilic Esophagitis

Rothenberg, Marc E.

doi:10.1053/j.gastro.2009.07.007

Cited by 264 publications

(231 citation statements)

References 136 publications

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“…It may also affect the level of activation-induced cytidinedeaminase (AID) and induce the colon inflammation as well as transformation into cancer cells (Endo et al, 2008). Moreover, IL-13 influences eosinophils and cause their prolonged survival, activation, and migration to inflammatory lesions (Rothenberg, 2009). Data show that IL-13 receptors are highly expressed in colonic epithelial cells.…”

Section: Introductionmentioning

confidence: 89%

ThelL-8andIL-13Gene Polymorphisms in Inflammatory Bowel Disease and Colorectal Cancer

Walczak

Przybyłowska

Dziki

et al. 2012

DNA and Cell Biology

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Inflammatory bowel diseases (IBD) and colorectal cancer (CRC) are disorders that originate from immune disturbances. In our study, we evaluated the association between the -251 T/A interleukin (IL)-8 and the -1112 C/T IL-13 polymorphisms, the risk of IBD, and CRC development. Genotypes were determined by PCRrestriction fragment length polymorphism in 191 patients with CRC, 150 subjects with IBD, and 205 healthy controls. We found an association between CRC and the presence of the -251 TA genotype and A allele of the IL-8 gene (odds ratios [ORs] 2.28 and 1.65). A similar relationship was observed between these polymorphic variants and ulcerative colitis (OR 2.05 for the -251 TA genotype and OR 1.47 for the -251 A allele) as well as Crohn's disease (ORs 3.11 and 1.56, respectively). Our research also revealed that the CT and TT genotypes of the IL-13 -1112 C/T polymorphism may be connected with a higher risk of CRC (ORs 2.28 and 1.65). The same genotypes affected the susceptibility of IBD (ORs 2.26 and 3.72). Our data showed that the IL-8 -251 T/A and IL-13 -1112 C/T polymorphisms might be associated with the IBD and CRC occurrence and might be used as predictive factors of these diseases in a Polish population.

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Section: Introductionmentioning

confidence: 89%

ThelL-8andIL-13Gene Polymorphisms in Inflammatory Bowel Disease and Colorectal Cancer

Walczak

Przybyłowska

Dziki

et al. 2012

DNA and Cell Biology

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“…Genetic susceptibility may play a role. Rothenberg et al associated a gene locus (5q22) to the disease (23,24) . In our study, two patients were from the same family.…”

Section: Discussionmentioning

confidence: 99%

“…The clinical features described by our study are similar to those reported elsewhere, with predominance of males (78.6%), as well as frequent abdominal pain, vomiting, failure to thrive and regurgitation, symptoms that resemble gastroesophageal reflux disease (GERD) (11,27) . Furthermore, EoE is a immunologically-mediated disease, and most patients present evidence of food allergy and/or atopy (7,24) . In the present study, 85.7% had history of atopy, more than the 68% that was reported elsewhere (27) .…”

Section: Discussionmentioning

confidence: 99%

Histological Features of Eosinophilic Esophagitis in Children and Adolescents

Carrasco

Machado

Patrı́cio

et al. 2017

Arq. Gastroenterol.

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-Background -Eosinophilic esophagitis is an emerging disease featured by eosinophilic esophageal infiltrate not responsive to proton pump inhibitors. Objective -To characterize histological features of children and adolescents with eosinophilic esophagitis. Methods -Cross-sectional study in a tertiary hospital. Biopsies from each esophageal third from 14 patients (median age 7 years) with eosinophilic esophagitis were evaluated. Histological features evaluated included morphometry of esophageal epithelium, esophageal density (per high power field), extracellular eosinophilic granules, eosinophilic microabscesses, surface disposition of eosinophils, epithelial desquamation, peripapillary eosinophilia, basal layer hyperplasia and papillary elongation. Results -Several patients presented a normal esophageal macroscopy in the upper digestive endoscopy (6, 42.8%), and the most common abnormality were vertical lines (7, 50%) and whitish spots over esophageal mucosa (7, 50%). Basal layer hyperplasia was observed in 88.8%, 100% e 80% of biopsies from proximal, middle and lower esophagus, respectively (P=0.22). Esophageal density ranges from 0 to more than 50 per hpf. Extracellular eosinophilic granules (70%-100%), surface disposition of eosinophils (60%-93%), epithelial desquamation (60%-100%), peripapillary eosinophilia (70%-80%) were common, but evenly distributed among each esophageal third. Just one patient did not present eosinophils in the lower third, four in the middle third and four in the upper esophageal third. Conclusion -In the absence of hypereosinophilia, other histological features are present in eosinophilic esophagitis and may contribute to diagnosis. Eosinophilic infiltrate is focal, therefore multiple biopsies are needed for diagnosis.

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“…107 Therefore avoidance of food antigens would be an important therapeutic strategy for EoE. There are three strategies for dietary approach in EoE; elemental diet, targeted elimination diet (after allergic testing) and six food elimination diet (SFED).…”

Section: Dietary Therapymentioning

confidence: 99%

Eosinophilic esophagitis

Kedia¹

2015

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Eosinophilic esophagitis (EoE) is a clinico-pathological entity characterised by symptoms of esophageal dysfunction and eosinophilia on esophageal mucosal biopsies in the absence of other causes of esophageal eosinophilia. It is a chronic inflammatory condition of esophagus often characterized by refractory reflux symptoms in children and dysphagia in adults. It occurs as a result of Th2 inflammatory response to environmental triggers (food antigens) in genetically predisposed individuals. The diagnostic criteria include symptoms of esophageal dysfunction, esophageal eosinophilia (> 15/hpf), and a PPI trial (persistent eosinophilia after 8 weeks of PPI). Mainstay of treatment at present is topical steroids and dietary therapy.Maintenance treatment should be considered to prevent long term complications.

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Biology and Treatment of Eosinophilic Esophagitis

Cited by 264 publications

References 136 publications

ThelL-8andIL-13Gene Polymorphisms in Inflammatory Bowel Disease and Colorectal Cancer

ThelL-8andIL-13Gene Polymorphisms in Inflammatory Bowel Disease and Colorectal Cancer

Histological Features of Eosinophilic Esophagitis in Children and Adolescents

Eosinophilic esophagitis

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