“…Immunologic mechanisms are involved in the etiology of the disease (4,7,9,11) . The article of Carrasco et al (1) highlights relevant topics on the histologic evaluation in pediatric patients with eosinophilic esophagitis, that is to say, the absence of visible abnormalities in the upper digestive endoscopy and the presence of eosinophilic infiltrate with focal distribution in a significant number of the patients. Therefore, from the practical point of view, it is important that multiple esophageal biopsies are performed even in the absence of classic abnormalities that may be seen in the esophagoscopy.…”