Biological functions and clinical applications of exosomal long non‐coding RNAs in cancer

Wang, Yali; Zhang, Mengdi; Zhou, Fangfang

doi:10.1111/jcmm.15873

Cited by 31 publications

(23 citation statements)

References 108 publications

(168 reference statements)

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“…In recent years, accumulating evidence has revealed fundamental roles of lncRNAs in the regulation of numerous physiological and pathological processes, such as cell differentiation, proliferation and apoptosis, and the initiation and progression of human cancer. [9][10][11] At present, it is widely acknowledged that numerous lncRNAs are involved the progression of DLBCL. For example, lncRNA SMAD5-AS1 inhibited proliferation of DLBCL as a ceRNA of to increase APC expression and limiting Wnt/β-catenin pathway.…”

Section: Discussionmentioning

confidence: 99%

LINC00908 Promotes Diffuse Large B-Cell Lymphoma Development by Down-Regulating miR-671-5p

Zeng¹,

Wei²,

Wei³

et al. 2021

CMAR

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Introduction Emerging evidence has revealed that long noncoding RNA (lncRNA) play important role in almost all kinds of human cancers. LINC00908 has been reported to be involved in the development of prostate cancer, colorectal cancer and gastric cancer which was functioned as an oncogene. However, the potential biology role and molecular mechanism of LINC00908 in diffuse large B-cell lymphoma are still unclear. Methods LINC00908 and miR-671-5p expression were evaluated in DLBCL tissues and cell lines using RT-qPCR. CCK-8 and transwell assay were used to analyze the in vitro role of LINC00908 in DLBCL progression. The xenograft model was used to explore the in vivo role of LINC00908 in DLBCL growth. The physical interaction between LINC00908 and miR-671-5p was confirmed using bioinformatics analysis and a dual luciferase assay, RIP and RNA pull down. Results The expression of LINC00908 was markedly up-regulated in diffuse large B-cell lymphoma tissues and cell lines, and the decreased expression of LINC00908 significantly inhibited diffuse large B-cell lymphoma cell proliferation and invasion. Then, we revealed that LINC00908 directly interacted with miR-671-5p, which was down-regulated in diffuse large B-cell lymphoma cells and highly expressed with LINC00908 knockdown. Moreover, luciferase reporter assays and RNA immunoprecipitation (RIP) assay further proved that miR-671-5p is a direct target of LINC00908 in diffuse large B-cell lymphoma cells. Rescue experiments were also performed, and we confirmed that LINC00908 acts as an oncogene role in diffuse large B-cell lymphoma through miR-671-5p. Finally, the influence of LINC00908 silence significantly inhibited diffuse large B-cell lymphoma growth in vivo. Conclusion LINC00908 promotes malignancy of diffuse large B-cell lymphoma through regulating miR-671-5p.

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Section: Discussionmentioning

confidence: 99%

LINC00908 Promotes Diffuse Large B-Cell Lymphoma Development by Down-Regulating miR-671-5p

Zeng¹,

Wei²,

Wei³

et al. 2021

CMAR

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“…Studies have confirmed that ncRNAs can be transferred between cells through exosomes [ 24 ]. Similarly, this study investigated whether uc.189 could form exosomes and transfer them from ESCC cells to HLECs.…”

Section: Resultsmentioning

confidence: 99%

Esophageal carcinoma cell-excreted exosomal uc.189 promotes lymphatic metastasis

Ding

Yan

Guo

et al. 2021

Aging

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Most cancers are old age-related diseases. Patients with lymphatic metastasis have an extremely poor prognosis in esophageal cancers (ECs). Previous studies showed ultraconserved RNAs are involved in tumorigenesis and ultraconserved RNA 189 (uc.189) served as an oncogene in cervical cancer, but the effect of exosomal uc.189 in esophageal squamous cell carcinoma (ESCC) remains undefined. This study revealed that uc.189 is closely correlated with lymph node (LN) metastasis and the number of lymphatic vessels in ESCC. ESCC-secreted exosomal uc.189 is transferred into human lymphatic endothelial cells (HLECs) to promote its proliferation, migration and tube formation to facilitate lymph node metastasis. Mechanistically, uc.189 regulated EPHA2 expression by directly binding to its 3’UTR region through dual-luciferase reporter assay. Over-expression and knockdown of EPHA2 could respectively rescue and simulate the effects induced by exosomal uc.189. Especially, the uc.189-EPHA2 axis activates the P38MAPK/VEGF-C pathway in HLECs. Finally, ESCC-secreted exosomal of uc.189 promotes HLECs sprouting in vitro , migration, and lymphangiogenesis. Thus, these findings suggested that exosomal uc.189 targets the EPHA2 of HLECs to promote lymphangiogenesis, and may represent a novel marker of diagnosis and treatment for ESCC patients in early stages.

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“…Exosomes release into the extracellular milieu influences cellular morphology by interfering with cell signaling components and by modulating recipient gene expressions and functions and the cell differentiation program. Exosomes have been reported to influence infections [ 91 , 92 , 93 ], tumor development and metastasis [ 94 , 95 , 96 , 97 , 98 ], neurodegenerative diseases [ 99 , 100 , 101 , 102 ], inflammation, and autoimmune disorders [ 103 , 104 , 105 , 106 ]. In addition, they play crucial role in intracellular communication and in the pathogenesis of several diseases as they can transfer signals (cytokines, proteins, lipids, nucleic acids, and infectious agents) from cells to nearby or distant locations [ 91 , 107 , 108 ].…”

Section: Immunomodulatory Effect Of Exosomesmentioning

confidence: 99%

Expedition into Exosome Biology: A Perspective of Progress from Discovery to Therapeutic Development

Jan

Rahman

Badierah

et al. 2021

Cancers

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Exosomes are membrane-enclosed distinct cellular entities of endocytic origin that shuttle proteins and RNA molecules intercellularly for communication purposes. Their surface is embossed by a huge variety of proteins, some of which are used as diagnostic markers. Exosomes are being explored for potential drug delivery, although their therapeutic utilities are impeded by gaps in knowledge regarding their formation and function under physiological condition and by lack of methods capable of shedding light on intraluminal vesicle release at the target site. Nonetheless, exosomes offer a promising means of developing systems that enable the specific delivery of therapeutics in diseases like cancer. This review summarizes information on donor cell types, cargoes, cargo loading, routes of administration, and the engineering of exosomal surfaces for specific peptides that increase target specificity and as such, therapeutic delivery.

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Biological functions and clinical applications of exosomal long non‐coding RNAs in cancer

Cited by 31 publications

References 108 publications

LINC00908 Promotes Diffuse Large B-Cell Lymphoma Development by Down-Regulating miR-671-5p

LINC00908 Promotes Diffuse Large B-Cell Lymphoma Development by Down-Regulating miR-671-5p

Esophageal carcinoma cell-excreted exosomal uc.189 promotes lymphatic metastasis

Expedition into Exosome Biology: A Perspective of Progress from Discovery to Therapeutic Development

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