Biological effects of α -adrenergic phentolamine on erythrocyte hemeprotein: Molecular insights from biorecognition behavior, protein dynamics and flexibility

Peng, Wei; Ding, Fei; Peng, Yu-Kui; Xie, Yong

doi:10.1016/j.jphotobiol.2017.04.035

Cited by 1 publication

(1 citation statement)

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“…Due to their unique biological properties and structural complexity, they have found use in chemical or biological studies . For example, antibodies, peptides, single‐chain nucleic acids, and carbohydrates have been successfully used as targeting agents for cancer cells that overexpress the corresponding antigen or receptor . Other small biomolecules, such as folic acid, are selectively internalized by cells through their corresponding receptor on the cell surface.…”

Section: Introductionmentioning

confidence: 99%

Bio‐Conjugated Advanced Materials for Targeted Disease Theranostics

Kwon

Yan

et al. 2020

Adv Funct Materials

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Human beings are “machines” that use endogenously produced biomolecules as “components” in signaling and for the maintenance of the body. These biomolecules consist of proteins, nucleic acids, and carbohydrates, which can either be extracted from biological substrates or synthesized by chemical/biochemical methods. These biomolecules have the ability to recognize/interact with other biomolecules that are overexpressed in disease cells. For targeted theranostics, strategies to chemically incorporate these natural biomolecules with advanced materials to treat human diseases by imaging‐guided drug delivery or photodynamic/photothermal therapy are proposed, with improved biocompatibility. Herein, recent research on construction of quantum dots, nanoparticles, and 2D material platforms decorated with antibodies, peptides, nucleic acid aptamers, carbohydrates, and folic acid for targeted diagnosis and treatment are summarized and discussed. In addition, the various strategies required to construct effective functional materials for targeted cancer therapy are highlighted. The hope is that this review can inspire and guide those that are interested in the field of biomedicine to rationally design and develop new target‐based theranostic materials.

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Section: Introductionmentioning

confidence: 99%