Biological effects of the olive tree and its derivatives on the skin

Melguizo‐Rodríguez, Lucia; González-Acedo, Anabel; Illescas‐Montes, Rebeca; García-Recio, Enrique; Ramos‐Torrecillas, Javier; Costela‐Ruiz, Víctor J.; García-Martínez, Olga

doi:10.1039/d2fo01945k

Cited by 7 publications

(6 citation statements)

References 127 publications

(217 reference statements)

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“…Additionally, a decrease in the expression of inflammatory markers such as IL-6 and IL-1α in response to ZP treatment was observed. These results are consistent with previous research highlighting the anti-inflammatory and antioxidant potential of phenolic compounds in skin cells [51,52,84,89]. Moreover, the negative modulation of AhR and Nrf2 by ZP suggests a potential interference in key signaling pathways related to oxidative stress.…”

Section: Discussionsupporting

confidence: 93%

Protective Potential of a Botanical-Based Supplement Ingredient against the Impact of Environmental Pollution on Cutaneous and Cardiopulmonary Systems: Preclinical Study

Peno-Mazzarino,

Radionov,

Merino

et al. 2024

CIMB

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Air pollution is a growing threat to human health. Airborne pollution effects on respiratory, cardiovascular and skin health are well-established. The main mechanisms of air-pollution-induced health effects involve oxidative stress and inflammation. The present study evaluates the potential of a polyphenol-enriched food supplement ingredient comprising Lippia citriodora, Olea europaea, Rosmarinus officinalis, and Sophora japonica extracts in mitigating the adverse effects of environmental pollution on skin and cardiopulmonary systems. Both in vitro and ex vivo studies were used to assess the blend’s effects against pollution-induced damage. In these studies, the botanical blend was found to reduce lipid peroxidation, inflammation (by reducing IL-1α), and metabolic alterations (by regulating MT-1H, AhR, and Nrf2 expression) in human skin explants exposed to a mixture of pollutants. Similar results were also observed in keratinocytes exposed to urban dust. Moreover, the ingredient significantly reduced pollutant-induced ROS production in human endothelial cells and lung fibroblasts, while downregulating the expression of apoptotic genes (bcl-2 and bax) in lung fibroblasts. Additionally, the blend counteracted the effect of urban dust on the heart rate in zebrafish embryos. These results support the potential use of this supplement as an adjuvant method to reduce the impact of environmental pollution on the skin, lungs, and cardiovascular tissues.

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Section: Discussionsupporting

confidence: 93%

Protective Potential of a Botanical-Based Supplement Ingredient against the Impact of Environmental Pollution on Cutaneous and Cardiopulmonary Systems: Preclinical Study

Peno-Mazzarino,

Radionov,

Merino

et al. 2024

CIMB

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“…Thus, there is a strong demand for good photo-protectors that can enhance the natural cutaneous pigmentation in the skin. In this context, olive extract and its major components were studied for their effects on melanogenesis and photoprotection [52][53][54]. However, previously, the effects of OL and OC on the skin were barely known.…”

Section: Discussionmentioning

confidence: 99%

“…Despite the many health benefits of olives, the specific effects of the individual olive component on the skin have yet to be studied intensively. Nevertheless, recent studies have reported the anti-inflammatory effect and UV protection effects of olive extract [52][53][54]. Building on those findings, in this study, we aimed to screen the effects of three olivederived compounds (OP, OL, and OC) on melanin production through mouse melanoma B16F10 cells, which originate from melanocytes and human epidermal melanocytes.…”

Section: Introductionmentioning

confidence: 99%

Comparative Analysis of Olive-Derived Phenolic Compounds’ Pro-Melanogenesis Effects on B16F10 Cells and Epidermal Human Melanocytes

Cho,

Bejaoui,

Tominaga

et al. 2024

IJMS

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Olive leaf contains plenty of phenolic compounds, among which oleuropein (OP) is the main component and belongs to the group of secoiridoids. Additionally, phenolic compounds such as oleocanthal (OL) and oleacein (OC), which share a structural similarity with OP and two aldehyde groups, are also present in olive leaves. These compounds have been studied for several health benefits, such as anti-cancer and antioxidant effects. However, their impact on the skin remains unknown. Therefore, this study aims to compare the effects of these three compounds on melanogenesis using B16F10 cells and human epidermal cells. Thousands of gene expressions were measured by global gene expression profiling with B16F10 cells. We found that glutaraldehyde compounds derived from olive leaves have a potential effect on the activation of the melanogenesis pathway and inducing differentiation in B16F10 cells. Accordingly, the pro-melanogenesis effect was investigated by means of melanin quantification, mRNA, and protein expression using human epidermal melanocytes (HEM). This study suggests that secoiridoid and its derivates have an impact on skin protection by promoting melanin production in both human and mouse cell lines.

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“…HvOle can be potentially used as an antioxidant for the reduction of the effects of oxidative stress on the skin and possibly preventing skin aging. The increasing consumers’ demand for green and natural compounds in view of their safer and healthier properties with respect to synthetic products is supporting the development of antioxidants of natural origin in several fields, including cosmetics. − In this context, lipophenols show an increased skin penetration capacity compared to their polar parent phenolics. Their lipophilicity plays a role in increasing their antimicrobial, antioxidant, or antiaging properties. ,,,,, …”

Section: Discussionmentioning

confidence: 99%

Homovanillyl Oleate, a Novel Lipophenol from Olive Plant with Antioxidant Properties

Benincasa,

Cersosimo,

Perri

et al. 2024

ACS Food Sci. Technol.

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Lipophenols represent a significant form in which some phenolic compounds exist. In this work, the occurrence of homovanillyl oleate (HvOle) was investigated in primary olive matrices (drupes and leaves), olive oil, and byproducts (pomace and pate). The assay of HvOle was conducted by liquid chromatography−mass spectrometry (LC/MS). Our data demonstrate the presence of HvOle in all the matrices analyzed, including olives and leaves, in which other lipophenols were never detected so far. The radical scavenging properties of HvOle were assessed against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2-azino bis(3ethylbenzothiazoline-6-sulfonic) acid (ABTS) radicals. HvOle partly retained the activity of its parent compound homovanillyl alcohol (HvA). Furthermore, the antioxidant properties of HvOle were investigated in H 2 O 2 -treated HaCat human keratinocyte cell line. HvOle decreased the amount of malondialdehyde (MDA), a marker of lipid peroxidation, and the enzymatic activity of superoxide dismutase (SOD) without affecting glutathione-S-transferase (GST). HvOle reduces oxidative stress and can be potentially useful for the prevention or reduction of skin aging.

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Biological effects of the olive tree and its derivatives on the skin

Abstract: The olive tree and its derivatives are of great interest in the field of biomedicine due to their numerous health properties. The aim of the present study was to identify...

Cited by 7 publications

References 127 publications

Protective Potential of a Botanical-Based Supplement Ingredient against the Impact of Environmental Pollution on Cutaneous and Cardiopulmonary Systems: Preclinical Study

Protective Potential of a Botanical-Based Supplement Ingredient against the Impact of Environmental Pollution on Cutaneous and Cardiopulmonary Systems: Preclinical Study

Comparative Analysis of Olive-Derived Phenolic Compounds’ Pro-Melanogenesis Effects on B16F10 Cells and Epidermal Human Melanocytes

Homovanillyl Oleate, a Novel Lipophenol from Olive Plant with Antioxidant Properties

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