Biological determinants of serum ICAM-1, E-selectin, P-selectin and L-selectin levels in healthy subjects: the Stanislas study

Ponthieux, Anne; Herbeth, Bernard; Droesch, Suzanne; Haddy, Nadia; Lambert, Daniel; Visvikis, Sophie

doi:10.1016/j.atherosclerosis.2003.11.003

Cited by 78 publications

(69 citation statements)

References 40 publications

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“…An earlier study showed that no sex-related difference in the concentrations of sICAM-1 has been seen in adolescents. 28 Our result was consistent with it.…”

Section: Discussionsupporting

confidence: 83%

The study of insulin resistance and soluble intercellular adhesion molecule-1 in normotensive adolescents with a family history of hypertension

Yin

Wang

et al. 2008

J Hum Hypertens

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To investigate the changes of insulin resistance and soluble intercellular adhesion molecule-1 (sICAM-1) in normotensive adolescents with a family history of hypertension (FH) and to analyse the related factors. The study included 142 normotensive adolescents aged 13-15 years. On the basis of an FH, the samples were divided into positive FH (FH þ group) and negative FH groups (FH À group). Anthropometric measurements included height, weight, waist circumference (WC) and blood pressure (BP). Blood samples were collected and fasting plasma glucose (FPG), serum lipids, true insulin (TI) and sICAM-1 were assayed. The In multiple linear regression analysis, WC (b ¼ 0.024, P ¼ 0.000) and FH (b ¼ 0.467, P ¼ 0.000) were significant independent predictors for HOMA-IR, and triglyceride (b ¼ 0.328, P ¼ 0.007) and FH (b ¼ 0.395, P ¼ 0.016) were significant independent predictors for sICAM-1. These results indicate that insulin resistance and endothelial activation were found in normotensive adolescents with an FH. We should make great efforts to alleviate the insulin resistance and endothelial activation by diet and exercise, and it would reduce the incidence of hypertension in adolescents with an FH.

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“…An earlier study showed that no sex-related difference in the concentrations of sICAM-1 has been seen in adolescents. 28 Our result was consistent with it.…”

Section: Discussionsupporting

confidence: 83%

The study of insulin resistance and soluble intercellular adhesion molecule-1 in normotensive adolescents with a family history of hypertension

Yin

Wang

et al. 2008

J Hum Hypertens

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“…Physical examinations and functional tests were performed and basic blood constituents were measured as previously described. 32 Serum hs-CRP was measured by immunonephelometry (Nephelometer Analyser BN II, Dade-Behring, Marburg, Germany) using Behring reagents (DadeBehring, Rueil-Malmaison, France). Two hs-CRP control samples were run with each batch of samples.…”

Section: Population Studiedmentioning

confidence: 99%

Heritability of serum hs-CRP concentration and 5-year changes in the Stanislas family study: association with apolipoprotein E alleles

et al. 2007

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We aimed at estimating additive genetic heritability, household component effect and the influence of common alleles of the apolipoprotein E gene (APOE) on serum high-sensitivity C-reactive protein (hs-CRP) concentrations and the subsequent changes over 5 years. A sub-sample of 320 nuclear families was randomly selected from the Stanislas Family Study. Serum hs-CRP concentration was measured by immunonephelometry at entrance and after 5 years. APOE alleles were determined by restriction fragment length polymorphism. After adjustment for covariates, the number of the e4 allele was negatively associated with serum concentration of hs-CRP in the whole sample, at entrance and 5 years later, without significant interaction with sex by generation groups (P ¼ 0.003 and P ¼ 0.0003, respectively). However, no significant association was found between e4 allele and 5-year changes in hs-CRP concentration. Using a variance component analysis, no significant genetic influence was shown in family aggregation of both hs-CRP measurements and 5-year changes; the household common component was between 6.5 and 12.8%. In addition, after adjustment for APOE gene polymorphisms, degrees of resemblance were almost unchanged. In the Stanislas Family Study, e4 allele of the APOE gene was associated with lower hs-CRP concentration, but not with 5-year changes. However, variance component analysis did not evidence a significant polygenic effect.

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“…Some studies have shown a positive correlation between intracellular adhesion molecule-1 (sICAM-1) and BMI 7,8 and sICAM-1 and WHR 9 whereas others have not. 4,[10][11][12] sE-selectin is also related to BMI or WHR in some 4,7,12 but not all studies. 11 The aim of this study was to explore these relationships more fully in a multiethnic population sample.…”

Section: Introductionmentioning

confidence: 99%

Cellular adhesion molecules and their relationship with measures of obesity and metabolic syndrome in a multiethnic population

Miller

Cappuccio

2006

Int J Obes

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Background:The relationships between adhesion molecules and measures of obesity and metabolic syndrome in different ethnic populations are unclear. Objective: Our aim was to study the association between body mass index (BMI), waist-hip ratio (WHR) and the parameters of the metabolic syndrome with four different adhesion molecules, adjusting for potential confounders, in men and women from different ethnic origins. Methods: Soluble plasma adhesion molecules (sP-selectin, sE-selectin, intracellular adhesion molecule-1 (sICAM-1) and vascular cell adhesion molecule-1 (sVCAM-1) were measured in 261 white (120 women), 188 African origin (99 women) and 215 South Asian (99 women) individuals living in South London. All were free from coronary heart disease (CHD), stroke and other cardiovascular disease (CVD), diabetes, drug therapy for hypertension or high lipids, hormone replacement therapy or oral contraceptive pill. Results: sE-selectin levels were positively and significantly associated with both BMI (Po0.001) and WHR (Po0.001). There were no major interactions with either sex or ethnicity. The strength of the association between sE-selectin and WHR was not affected by multiple adjustment for age, sex, ethnicity smoking, blood pressure, serum lipids and insulin (Po0.001), whereas the association with BMI was attenuated by multiple adjustments (P ¼ 0.037). An approximate 2% higher sE-selectin levels would be associated with a 1 unit higher BMI and a 0.01 unit greater WHR. Conclusions: The relationships between adhesion molecules and conventional measures of obesity are adhesion molecule specific and are strongest between sE-selectin and WHR.

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Biological determinants of serum ICAM-1, E-selectin, P-selectin and L-selectin levels in healthy subjects: the Stanislas study

Cited by 78 publications

References 40 publications

The study of insulin resistance and soluble intercellular adhesion molecule-1 in normotensive adolescents with a family history of hypertension

The study of insulin resistance and soluble intercellular adhesion molecule-1 in normotensive adolescents with a family history of hypertension

Heritability of serum hs-CRP concentration and 5-year changes in the Stanislas family study: association with apolipoprotein E alleles

Cellular adhesion molecules and their relationship with measures of obesity and metabolic syndrome in a multiethnic population

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