Cellular adhesion molecules and their relationship with measures of obesity and metabolic syndrome in a multiethnic population

Miller, Michelle A.; Cappuccio, Francesco P.

doi:10.1038/sj.ijo.0803264

Cited by 41 publications

(40 citation statements)

References 24 publications

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“…A high level of inflammation (assessed by hs-CRP) in hypertensive patients with acute ischemic stroke has been linked to an increased risk of future cardiovascular mortality [34]. A study on normotensive subjects revealed that adhesion molecules, particularly the sE-selectin, relates to obesity (waist and hip ratio), whereas the relationship between adhesion molecules and BP in hypertensive subjects is adhesion molecule-specific and varies with sex and age, which may partially explain inconsistencies found in the literature [35].…”

Section: Multivariate Analysis Of the Effects Of Vitamin Supplementatmentioning

confidence: 72%

Blood Pressure Reduction is Associated With the Changes in Oxidative Stress and Endothelial Activation in Hypertension, Regardless of Antihypertensive Therapy

Mihalj

Tadžić²,

Včev³

et al. 2016

Kidney Blood Press Res

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Background/Aims: Hypertensive patients present with increased oxidative stress and frequently receive angiotensin II (ANGII) receptor type I blockers (ARB) for blood pressure (BP) reduction. Recent studies revealed an important role of ANGII in maintaining vascular oxidative homeostasis, including sustaining normal sodium dismutase activity. This study aimed to investigate the effects of antihypertensive therapy and also vitamin C/E supplementation on BP, oxidative stress and endothelial activation in patients with essential hypertension. Methods: Newly discovered patients received ARB/olmesartan or the Ca²⁺-channel blocker (CCB)/amlodipine, and additionally vitamin C/E or placebo throughout weeks 9-16. ELISA was used to determine 8-iso-prostaglendin F2-alpha (8iPGF2α) and endothelial activation markers. Results: In both groups BP was normalized during first 8 weeks of therapy. Vitamins C/E had no additional BP-lowering effect. The vitamins C/E supplementation was not effective in reducing absolute values of 8iPGF2α; however; the magnitude of 8iPGF2α reduction was significantly greater in patients taking vitamins C/E in the CCB group. Although plasma 8iPGF2α positively correlated to BP, a significant decrease occurred during an additional 8 weeks of treatment. There were no changes in endothelial activation markers related to the specific action of ARB or CCB. Conclusions: Present study suggests that observed oxidative stress is a consequence of hypertension. BP reduction is associated with the observed decrease in oxidative stress and changes in endothelial activation regardless of antihypertensive therapy.

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Section: Multivariate Analysis Of the Effects Of Vitamin Supplementatmentioning

confidence: 72%

Blood Pressure Reduction is Associated With the Changes in Oxidative Stress and Endothelial Activation in Hypertension, Regardless of Antihypertensive Therapy

Mihalj

Tadžić²,

Včev³

et al. 2016

Kidney Blood Press Res

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“…Finally, leukocytes infiltrate the extravascular space via PECAM-1. There is a good body of evidence showing increased levels of serum-soluble adhesion molecules, including soluble ICAM-1, VCAM-1, P-selectin, and E-selectin, in obese populations (11), and obesity is also associated with persistent platelet activation (12). These data suggest that obese adipose tissue is a site of enhanced interaction between ECs and leukocytes.…”

Section: Introductionmentioning

confidence: 92%

In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue

Nishimura

Manabe²,

Nagasaki³

et al. 2008

J. Clin. Invest.

197

182

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To assess physiological and pathophysiological events that involve dynamic interplay between multiple cell types, real-time, in vivo analysis is necessary. We developed a technique based on confocal laser microscopy that enabled us to analyze and compare the 3-dimensional structures, cellular dynamics, and vascular function within mouse lean and obese adipose tissue in vivo with high spatiotemporal resolution. We found increased leukocyte-EC-platelet interaction in the microcirculation of obese visceral adipose tissue in ob/ob and highfat diet-induced obese mice. These changes were indicative of activation of the leukocyte adhesion cascade, a hallmark of inflammation. Local platelet activation in obese adipose tissue was indicated by increased P-selectin expression and formation of monocyte-platelet conjugates. We observed upregulated expression of adhesion molecules on macrophages and ECs in obese visceral adipose tissue, suggesting that interactions between these cells contribute to local activation of inflammatory processes. Furthermore, administration of anti-ICAM-1 antibody normalized the cell dynamics seen in obese visceral fat. This imaging technique to analyze the complex cellular interplay within obese adipose tissue allowed us to show that visceral adipose tissue obesity is an inflammatory disease. In addition, this technique may prove to be a valuable tool to evaluate potential therapeutic interventions.

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“…In older adults elevated D-dimer levels accompany insulin resistance (16). In middle-aged adults sICAM-1 has been shown to be associated with insulin resistance (17), although other studies show no such association (18).…”

mentioning

confidence: 99%

“…[17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32]. The primary data analytical approaches included Pearson correlation and multiple linear regression.…”

mentioning

confidence: 99%

Metabolic Predictors of Inflammation, Adhesion, and Coagulability in Healthy Younger‐aged Adults

Mills

Shapiro

Goldstein

et al. 2008

Obesity

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Elevated levels of inflammatory biomarkers are associated with the pathophysiology of cardiovascular diseases and are predictors of cardiovascular events. The objective of this study was to determine the unique contributions of metabolic factors as predictors of inflammation (C‐reactive protein (CRP) and interleukin‐6 (IL‐6)), adhesion (soluble intercellular adhesion molecule‐1 (sICAM‐1)), and coagulation (D‐dimer) in healthy younger‐aged adults. Participants were 83 women and 92 men (mean age 30.04 years, s.d. ± 4.8, range 22–39) of normal weight to moderate obese weight (mean BMI 24.4 kg/m2, s.d. ± 3.35, range 17–32). The primary data analytical approaches included Pearson correlation and multiple linear regression. Circulating levels of CRP, IL‐6, sICAM‐1, and D‐dimer were determined in plasma. Higher levels of CRP were independently associated with higher BMI, a greater waist‐to‐hip ratio, female gender, and higher triglycerides (P < 0.001). Higher IL‐6 levels were independently associated with a greater waist‐to‐hip ratio (P < 0.01). Higher levels of sICAM‐1 were independently associated with higher BMI, higher triglycerides, and lower insulin resistance (P < 0.001). Higher D‐dimer levels were independently associated with higher BMI and being female (P < 0.001). Having a higher BMI was most consistently associated with elevated biomarkers of inflammation, adhesion, and coagulation in this sample of healthy younger‐aged adults, although female gender, insulin resistance, and lipid levels were also related to the biomarkers. The findings provide insight into the adverse cardiovascular risk associated with elevated body weight in younger adults.

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Cellular adhesion molecules and their relationship with measures of obesity and metabolic syndrome in a multiethnic population

Cited by 41 publications

References 24 publications

Blood Pressure Reduction is Associated With the Changes in Oxidative Stress and Endothelial Activation in Hypertension, Regardless of Antihypertensive Therapy

Blood Pressure Reduction is Associated With the Changes in Oxidative Stress and Endothelial Activation in Hypertension, Regardless of Antihypertensive Therapy

In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue

Metabolic Predictors of Inflammation, Adhesion, and Coagulability in Healthy Younger‐aged Adults

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