Biological clock: Biological clocks may modulate drug addiction

Yuferov, Vadim; Butelman, Eduardo R.; Kreek, Mary Jeanne

doi:10.1038/sj.ejhg.5201483

Cited by 31 publications

(23 citation statements)

References 12 publications

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“…The down-regulation of Per2 observed in NON-EXT animals is coherent with the positive effect of HFD in food-conditioning, as Per2 has been shown to be relevant in connecting drugs of abuse-entrainable pacemakers and food [23][24][25][26]. Moreover, engineered Per2 deletion has been shown to increase cocaine [27] and ethanol reward [28].…”

Section: Discussionmentioning

confidence: 81%

Involvement of the dorsomedial prefrontal cortex in high-fat food conditioning in adolescent mice

Rio

Cano

Martín-Ramos

et al. 2015

Behavioural Brain Research

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Section: Discussionmentioning

confidence: 81%

Involvement of the dorsomedial prefrontal cortex in high-fat food conditioning in adolescent mice

Rio

Cano

Martín-Ramos

et al. 2015

Behavioural Brain Research

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“…It has been hypothesized that it is through these "non-clock" functions that these circadian genes interact with systems involved in the development of cocaine addiction (Manev and Uz 2006;Uz et al 2003;Yuferov et al 2005b). For example, it has been reported that stimulant drug treatment produces gene expression changes in Per gene expression in the striatum without affecting the rhythmic expression in SCN (Manev and Uz 2006).…”

Section: Discussionmentioning

confidence: 99%

Gene profiling the response to repeated cocaine self-administration in dorsal striatum: A focus on circadian genes

et al. 2008

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Alterations in gene expression in the dorsal striatum caused by chronic cocaine exposure have been implicated in the long-term behavioral changes associated with cocaine addiction. To gain further insight into the molecular alterations that occur as a result of cocaine self-administration, we conducted a microarray analysis of gene expression followed by bioinformatic gene network analysis that allowed us to identify adaptations at the level of gene expression as well as into interconnected networks. Changes in gene expression were examined in the dorsal striatum of rats 1 day after they had self-administered cocaine for 7 days under a 24-hr access, discrete trial paradigm (averaging 98 mg/kg/day). Here we report the regulation of the circadian genes Clock, Bmal1, Cryptochrome1, Period2, as well as several genes that are regulated by/associated with the circadian system (i.e., early growth response 1, dynorphin). We also observed regulation of other relevant genes (i.e., Nur77, beta catenin). These changes were then linked to curated pathways and formulated networks which identified circadian rhythm processes as affected by cocaine self-administration. These data strongly suggest involvement of circadian-associated genes in the brain's response to cocaine and may contribute to an understanding of addictive behavior including disruptions in sleep and circadian rhythmicity. Classification Molecular Brain Research SectionDisease-Related Neuroscience

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“…The neuroadaptation within the mesocorti-colimbic dopaminergic pathway, involving ventral teg-mental area, nucleus accumbens, and prefrontal cortex, is a major player in the development of behavioral sensitization (Chen et al 2009; Chong et al 2012; Claussen et al 2012; Claussen and Dafny 2012; Podet et al 2010; Salek et al 2012; Robinson and Becker 1986; Kalivas and Stewart 1991; Nestler 2002; Everitt and Robbins 2005; Kalivas and O’Brien 2008). Although not completely understood yet, there seems to be a relationship between behavioral sensitization and circadian clock genes in the brain, (Yuferov et al 2005; Abarca et al 2002; McClung et al 2005) because the degree of sensitization to psychostimulant is time dependent (Abarca et al 2002). In other words, the degree of behavioral sensitization is dependent on which phase of a daily rhythm the subject is in when cocaine was administered.…”

Section: Discussionmentioning

confidence: 99%

Behavioral daily rhythmic activity pattern of adolescent female rat is modulated by acute and chronic cocaine

Lee¹,

Burau²,

Dafny³

2013

J Neural Transm

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Cocaine is one of well-known drugs of abuse, and many children experience early exposure to cocaine. Because of an immature neuronal system in adolescents, they may react differently to repeated cocaine administration compared to adults. Most of the published papers report the effect of cocaine on adult male rats and this paper focused on the effects of cocaine on the 24 h locomotor activity rhythm patterns activity of adolescent Sprague Dawley (SD) female rats. Changes in the locomotor activity rhythm patterns could indicate that cocaine elicits long-term changes in the clock genes of the body that regulate different physiological processes. The objective of this study was to investigate whether cocaine in adolescent female rats modulated their daily activity pattern. Animals were divided into control (saline), 3.0, 7.5, 15.0 mg/kg cocaine groups. On experimental day 1 (ED 1), all groups were given saline injection. From ED 2 to ED 7, either saline or cocaine (3.0, 7.5, or 15.0 mg/kg) was given daily. ED 8 to ED 10 were the washout days, where no injection was given. On ED 11, the animals were injected with saline or with the same dose of cocaine as they were treated on ED 2 to ED 7. Each animal’s locomotor activities was recorded nonstop following saline or cocaine injection for 11 consecutive days using the open field assay. In conclusion, it was observed that all three groups receiving repeated cocaine administration (3.0, 7.5, and 15.0 mg/kg) displayed significantly altered locomotor activity rhythm patterns.

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Biological clock: Biological clocks may modulate drug addiction

Cited by 31 publications

References 12 publications

Involvement of the dorsomedial prefrontal cortex in high-fat food conditioning in adolescent mice

Involvement of the dorsomedial prefrontal cortex in high-fat food conditioning in adolescent mice

Gene profiling the response to repeated cocaine self-administration in dorsal striatum: A focus on circadian genes

Behavioral daily rhythmic activity pattern of adolescent female rat is modulated by acute and chronic cocaine

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