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Rationale: Recent U.S. data suggest an increased risk of work-related asthma among health care workers, yet only a few specific determinants have been elucidated. Objectives: To evaluate associations of asthma prevalence with occupational exposures in a cross-sectional survey of health care professionals. Methods: A detailed questionnaire was mailed to a random sample (n ϭ 5,600) of all Texas physicians, nurses, respiratory therapists, and occupational therapists with active licenses in 2003. Information on asthma symptoms and nonoccupational asthma risk factors obtained from the questionnaire was linked to occupational exposures derived through an industry-specific job-exposure matrix. Measurements: There were two a priori defined outcomes: (1 ) physiciandiagnosed asthma with onset after entry into health care ("reported asthma") and (2 ) "bronchial hyperresponsiveness-related symptoms," defined through an 8-item symptom-based predictor. Conclusions:The contribution of occupational exposures to asthma in health care professionals is not trivial, meriting both implementation of appropriate controls and further study.

A prospective, multicenter phase I trial was undertaken by the North American Clinical Trials Network (NACTN) to investigate the pharmacokinetics and safety of, as well as obtain pilot data on, the effects of riluzole on neurological outcome in acute spinal cord injury (SCI). Thirty-six patients, with ASIA impairment grades A-C (28 cervical and 8 thoracic) were enrolled at 6 NACTN sites between April 2010 and June 2011. Patients received 50 mg of riluzole PO/NG twice-daily, within 12 h of SCI, for 14 days. Peak and trough plasma concentrations were quantified on days 3 and 14. Peak plasma concentration (Cmax) and systemic exposure to riluzole varied significantly between patients. On the same dose basis, Cmax did not reach levels comparable to those in patients with amyotrophic lateral sclerosis. Riluzole plasma levels were significantly higher on day 3 than on day 14, resulting from a lower clearance and a smaller volume of distribution on day 3. Rates of medical complications, adverse events, and progression of neurological status were evaluated by comparison with matched patients in the NACTN SCI Registry. Medical complications in riluzole-treated patients occurred with incidences similar to those in patients in the comparison group. Mild-to-moderate increase in liver enzyme and bilirubin levels were found in 14-70% of patients for different enzymes. Three patients had borderline severe elevations of enzymes. No patient had elevated bilirubin on day 14 of administration of riluzole. There were no serious adverse events related to riluzole and no deaths. The mean motor score of 24 cervical injury riluzole-treated patients gained 31.2 points from admission to 90 days, compared to 15.7 points for 26 registry patients, a 15.5-point difference (p=0.021). Patients with cervical injuries treated with riluzole had more-robust conversions of impairment grades to higher grades than the comparison group.

The hypothesis that low decision latitude and high psychologic demand are associated with an increased risk of the incidence of and mortality from coronary heart disease was investigated in a 25-year follow-up study of 1,683 men aged 38-56 years who participated in the Chicago Western Electric Study (1957-1983). Scores for decision latitude and psychologic demand, which had been linked to the 1960 US Census occupation codes, were assigned to men in the Western Electric cohort based on job title at the initial examination (1957-1958). After adjustment for major coronary risk factors, the relative risk for 25-year coronary death was 0.76 (95% confidence interval (CI) 0.59-1.00) for a 20-point increase in the decision latitude score (approximate difference between tertiles) and was 0.78 (95% CI 0.48-1.26) for a 10-point increase in the psychologic demand score (approximate difference between three groups). For job strain (defined by low decision latitude and high psychologic demand), it was 1.40 (95% CI 0.92-2.14). Controlling for occupational class reduced the magnitude of the relative risks between job characteristics and coronary mortality. Analysis stratified by occupational class indicated that the effect of decision latitude was more pronounced for white-collar than for blue-collar workers. This study provided only limited evidence for associations between job characteristics and coronary heart disease mortality.

A series of new semiconducting polymers based on 4,4‐dihexyl‐4H‐cyclopenta[2,1‐b:3,4‐b′]dithiophene, 2,2‐dihexyl‐2H‐benzimidazole, and thiophene units was synthesized. The polymers show good solubility at room temperature in organic solvents owing to long alkyl chain in new acceptor, 2,2‐dihexyl‐2H‐benzimidazole. The advantage of dihexyl‐2H‐benzimidazole compared to the benzothiadiazole is to improve the solubility of the polymer. It was found that these polymers can finely be tuned for photovoltaic application by adjusting the contents ratio of the dihexyl‐2H‐benzimidazole unit. The spectra of the solid films show absorption bands with maximum peaks in the range of 421–577 nm and the absorption onsets at 588–683 nm, corresponding to band gaps of 2.11–1.82 eV. The devices with PCPDTDTHBI‐1:PC71BM showed an open‐circuit voltage (VOC) of 0.46 V, a short‐circuit current density (JSC) of 3.83 mA/cm2, and a fill factor of 0.36, giving a power conversion efficiency of 0.64%. Decrease of the dihexyl‐2H‐benzimidazole contents in the polymers induced red‐shift of the UV absorptions, and increased VOC and JSC values, to improve the efficiency of organic photovoltaics. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2010