Biological Chemistry and Physiopathology of Metabolism During Fever

Abstract

Physiopathology determines the causes and conditions of pathological processes, in other words, of aetiology, as well as the mechanisms of their production, namely pathogenesis; this discipline studies the general reactions of the organism, regardless of the form of the disease by which they would manifest themselves; it also studies the general rules for the occurrence and evolution of the disorders of the functions of different systems which depend on the properties of the whole organism. The tasks of physiopathology become clearer when we compare it with the tasks of the clinical investigation. Physiopathology clarifies the causes and the mechanism of the onset of a thermal reaction of the body, such as fever; the clinical part, in this case, deals with certain well-defined forms of febrile disorders, especially of infectious origin. Physiopathology studies the general rules of occurrence and development of the inflammatory process, while the clinical disciplines investigate a number of diseases caused by different forms of inflammation. Physiopathology is closely related to biology. The personal clinical study was carried out during the period 2016-2018 on a sample of 362 patients, who showed changes in the functions of different systems and organs during fever. The problem of the influence of fever, seen as a general reaction of the organism to the action of infectious agents, is of major importance in clarifying the role of fever as a reaction of adaptation in the fight of the body against infection, and it largely determines its treatment. Excessive temperature increase, as well as a sudden drop, can exert a harmful effect on the body.

Morphology of the Dorsomedial and Ventral Hypothalamic Nuclei

“…Якщо говорити про важливість сірого горба гіпоталамуса, то тут інформації менше. Наприклад, є праці щодо порушення ліпідного обміну при підвищенні температури тіла, власне пов'язані зі змінами центру ліпідного обміну в сірому горбі гіпоталамуса [8]. Також відомі дані про розвиток вторинної аменореї [9], порушень, що імітують захворювання гіпофіза [10] у жінок з утворами сірого горба.…”

“…When it comes to the importance of the tuber cinereum of the hypothalamus, there is less information available. For example, there are studies on lipid metabolism disorders with fever, which are actually associated with changes in the lipid metabolism centre in the tuber cinereum of the hypothalamus [8]. There is also evidence of secondary amenorrhoea [9] and disorders mimicking pituitary disease [10] in women with tuber cinereum formations.…”

Study on the Antipyretic and Anti-inflammatory Mechanism of Shuanghuanglian Oral Liquid Based on Gut Microbiota-Host Metabolism

“…Fever can be defined as a physiological stress response characterized by a higher body temperature than the upper limit of normal human temperature. This increase in tightly-regulated body temperature often exerts several adverse effects on clinical outcomes of various illnesses such as metabolic disorders and nerve damage ( Bligh et al, 1973 ; Polderman, 2008 ; Onisor et al, 2019 ). As inflammation is one of the common causes of fever, inflammatory diseases are often accompanied by elevated body temperature.…”