2010
DOI: 10.3390/polym2020057 View full text |Buy / Rent full text
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Abstract: Some new phenomena involved in the physical properties of comb polyelectrolyte solutions are reviewed. Special emphasis is given to synthetic biomimetic materials, and the structures formed by these molecules are compared with those of naturally occurring glycoprotein and proteoglycan solutions. Developments in the determination of the structure and dynamics (viscoelasticity) of comb polymers in solution are also covered. Specifically the appearance of multi-globular structures, helical instabilities, liquid c… Show more

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“…Divalent ions, such as Ca 2+ , are known to reduce swelling in mucin gel networks at low pH, as the acidic groups in the carbohydrate side chains become less charged exposing hydrophobic sites. These hydrophobic interactions form non-covalent cross-links between mucins that lead to and maintain the gel state 5,25,31,54 .…”
Section: Mucin Rheological Behavior and Microstructure As A Function mentioning
“…PGM is relatively easy to extract and widely available commercially. In addition, PGM solutions are generally considered a viable system to examine mucus sol-gel behavior due to similarities in physiological function 12,24,25 , although differences between native mucus and PGM solutions were observed in a prior study examining nanoparticle transport 26 . In addition to availability and physiological similarity, another critical benefit in using PGM solutions for fundamental studies is removal of variations in mucin concentration, type, and extraction method, as well as patient to patient variation that occurs with native mucus sources 27,28 .…”
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“…This state is hardly compatible with a simple collapsed random-coil conformation. Mucins, however, have the characteristic features of triblock copolymers with comb glycosylated hydrophilic rigid blocks flanked by flexible globular hydrophobic blocks (Di Cola et al 2008;Waigh and Papagiannopoulos 2010). A characteristic feature of block copolymers is that they can fold to form ordered compact metastable liquid crystalline phases (Halperin 1991).…”
Section: Mucin Polymer Foldingmentioning
“…This branched geometry causes brush polymers to have unique conformational behaviors that can impart particular characteristics to bulk materials. The brush geometry can be found in biological macromolecules within the extracellular matrix of tissues [1][2][3][4], and there has been recent interest in materials applications of networks of synthetic brush polymers [5].…”
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