2012
DOI: 10.1101/cshperspect.a009597
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Abstract: Our purpose here is not to address specific issues of mucus pathology, but to illustrate how polymer networks theory and its remarkable predictive power can be applied to study the supramolecular dynamics of mucus. Avoiding unnecessary mathematical formalization, in the light of available theory, we focus on the rather slow progress and the still large number of missing gaps in the complex topology and supramolecular dynamics of airway mucus. We start with the limited information on the polymer physics of resp… Show more

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Cited by 81 publications
(55 citation statements)
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“…Formation of the disulfide bonds is necessary for giving the mucus its viscous nature (8). The exact form of the disulfide bonds and final structure of the MUC2 oligomer are not yet fully understood; however, it is well perceived that transport and retention in the secretory vesicles are crucial for MUC2 oligomerization, mainly due to distinct chemical environment in the vesicles (7,24,25). Based on our findings described here, we suggest that in TMF −/− mouse goblet cells, the prolonged retention of MUC2 in secretory granules results in more extensive disulfide bond formation and oligomerization of MUC2, thereby leading to the formation of increased mucus viscosity.…”
Section: Discussionmentioning
confidence: 99%
“…Formation of the disulfide bonds is necessary for giving the mucus its viscous nature (8). The exact form of the disulfide bonds and final structure of the MUC2 oligomer are not yet fully understood; however, it is well perceived that transport and retention in the secretory vesicles are crucial for MUC2 oligomerization, mainly due to distinct chemical environment in the vesicles (7,24,25). Based on our findings described here, we suggest that in TMF −/− mouse goblet cells, the prolonged retention of MUC2 in secretory granules results in more extensive disulfide bond formation and oligomerization of MUC2, thereby leading to the formation of increased mucus viscosity.…”
Section: Discussionmentioning
confidence: 99%
“…A major consequence of the altered luminal environment is the accumulation of mucus in the CF intestine. Along with adequate fluid volume, bicarbonate appears to be crucial to the normal expansion and solubility of intestinal mucus (Garcia et al 2009;Verdugo 2012). It can be argued that excessive mucus accumulation is the most important pathological event in CF disease, as this contributes to most of the other sequelae of this disease.…”
Section: Obstructionmentioning
confidence: 99%
“…Furthermore, the many acidic residues of TFF2, often clustered, could also serve as additional Ca 2+ binding sites. During exocytosis, rapid unfolding of condensed mucins is triggered by an exchange of Ca 2+ against Na + from the extracellular fluid thus doubling the number of counter-ions and causing the mucin polymer to expand up to 600-fold in its volume by osmotic swelling within 20-30 msec (108,122,123,124). Of special note, HCO 3 -plays a crucial role for the extremely rapid transition into the expanded hydrated phase because it efficiently competes for Ca 2+ binding (125).…”
Section: Function Of Tff2 For Muc6 Assembly In the Secretory Pathway mentioning
confidence: 99%